| Full name: CD244 molecule | Alias Symbol: 2B4|NAIL|NKR2B4|Nmrk|SLAMF4 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 51744 | HGNC ID: HGNC:18171 | Ensembl Gene: ENSG00000122223 | OMIM ID: 605554 |
| Drug and gene relationship at DGIdb | |||
CD244 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of CD244:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD244 | 51744 | 220307_at | -0.1273 | 0.6928 | |
| GSE20347 | CD244 | 51744 | 220307_at | -0.1780 | 0.0494 | |
| GSE23400 | CD244 | 51744 | 220307_at | -0.1734 | 0.0000 | |
| GSE26886 | CD244 | 51744 | 220307_at | -0.1335 | 0.5655 | |
| GSE29001 | CD244 | 51744 | 220307_at | -0.1933 | 0.2898 | |
| GSE38129 | CD244 | 51744 | 220307_at | -0.3061 | 0.0000 | |
| GSE45670 | CD244 | 51744 | 220307_at | 0.0169 | 0.9238 | |
| GSE53622 | CD244 | 51744 | 66511 | -0.0242 | 0.8363 | |
| GSE53624 | CD244 | 51744 | 66511 | 0.6822 | 0.0000 | |
| GSE63941 | CD244 | 51744 | 220307_at | 0.0820 | 0.6470 | |
| GSE77861 | CD244 | 51744 | 220307_at | -0.1732 | 0.0630 | |
| SRP064894 | CD244 | 51744 | RNAseq | -0.5541 | 0.0395 | |
| SRP133303 | CD244 | 51744 | RNAseq | -0.9184 | 0.0080 | |
| SRP159526 | CD244 | 51744 | RNAseq | -0.5491 | 0.5379 | |
| SRP193095 | CD244 | 51744 | RNAseq | -1.2147 | 0.0000 | |
| SRP219564 | CD244 | 51744 | RNAseq | 0.3513 | 0.4779 | |
| TCGA | CD244 | 51744 | RNAseq | 0.2412 | 0.4990 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CD244 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD244:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD244 | 51744 | 10 | 0 | 20 | |
| GSE20123 | CD244 | 51744 | 10 | 0 | 20 | |
| GSE43470 | CD244 | 51744 | 7 | 2 | 34 | |
| GSE46452 | CD244 | 51744 | 2 | 1 | 56 | |
| GSE47630 | CD244 | 51744 | 14 | 0 | 26 | |
| GSE54993 | CD244 | 51744 | 0 | 6 | 64 | |
| GSE54994 | CD244 | 51744 | 16 | 0 | 37 | |
| GSE60625 | CD244 | 51744 | 0 | 0 | 11 | |
| GSE74703 | CD244 | 51744 | 7 | 2 | 27 | |
| GSE74704 | CD244 | 51744 | 4 | 0 | 16 | |
| TCGA | CD244 | 51744 | 45 | 3 | 48 |
Total number of gains: 115; Total number of losses: 14; Total Number of normals: 359.
Somatic mutations of CD244:
Generating mutation plots.
Highly correlated genes for CD244:
Showing top 20/565 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD244 | ADH6 | 0.68999 | 5 | 0 | 5 |
| CD244 | PSG1 | 0.680387 | 5 | 0 | 5 |
| CD244 | RBP4 | 0.678573 | 3 | 0 | 3 |
| CD244 | KLRG1 | 0.673143 | 5 | 0 | 5 |
| CD244 | GRIN1 | 0.67148 | 3 | 0 | 3 |
| CD244 | C16orf70 | 0.670892 | 3 | 0 | 3 |
| CD244 | MYO1A | 0.670788 | 6 | 0 | 6 |
| CD244 | DNTT | 0.669967 | 4 | 0 | 3 |
| CD244 | SPIN2A | 0.664109 | 4 | 0 | 4 |
| CD244 | SLC22A14 | 0.658405 | 6 | 0 | 5 |
| CD244 | PIWIL2 | 0.65806 | 6 | 0 | 5 |
| CD244 | DNAI1 | 0.657371 | 3 | 0 | 3 |
| CD244 | PDYN | 0.653163 | 6 | 0 | 5 |
| CD244 | DNMT3L | 0.652534 | 3 | 0 | 3 |
| CD244 | GABRG2 | 0.651058 | 3 | 0 | 3 |
| CD244 | IFNA8 | 0.645472 | 4 | 0 | 3 |
| CD244 | PDE6B | 0.644975 | 3 | 0 | 3 |
| CD244 | OR3A1 | 0.643447 | 3 | 0 | 3 |
| CD244 | TSHB | 0.641963 | 5 | 0 | 4 |
| CD244 | PKHD1 | 0.640307 | 3 | 0 | 3 |
For details and further investigation, click here
