| Full name: apolipoprotein A5 | Alias Symbol: RAP3|APOA-V | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 116519 | HGNC ID: HGNC:17288 | Ensembl Gene: ENSG00000110243 | OMIM ID: 606368 |
| Drug and gene relationship at DGIdb | |||
APOA5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of APOA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOA5 | 116519 | 224243_at | -0.0972 | 0.7155 | |
| GSE26886 | APOA5 | 116519 | 224243_at | -0.1121 | 0.3490 | |
| GSE45670 | APOA5 | 116519 | 224243_at | 0.0204 | 0.8517 | |
| GSE53622 | APOA5 | 116519 | 6011 | 0.1360 | 0.2661 | |
| GSE53624 | APOA5 | 116519 | 6011 | 0.0257 | 0.8542 | |
| GSE63941 | APOA5 | 116519 | 224243_at | -0.0672 | 0.6731 | |
| GSE77861 | APOA5 | 116519 | 224243_at | -0.1770 | 0.0364 | |
| TCGA | APOA5 | 116519 | RNAseq | -0.5583 | 0.6790 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by APOA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOA5 | 116519 | 0 | 13 | 17 | |
| GSE20123 | APOA5 | 116519 | 0 | 13 | 17 | |
| GSE43470 | APOA5 | 116519 | 2 | 8 | 33 | |
| GSE46452 | APOA5 | 116519 | 3 | 26 | 30 | |
| GSE47630 | APOA5 | 116519 | 2 | 19 | 19 | |
| GSE54993 | APOA5 | 116519 | 10 | 0 | 60 | |
| GSE54994 | APOA5 | 116519 | 5 | 19 | 29 | |
| GSE60625 | APOA5 | 116519 | 0 | 3 | 8 | |
| GSE74703 | APOA5 | 116519 | 1 | 5 | 30 | |
| GSE74704 | APOA5 | 116519 | 0 | 9 | 11 | |
| TCGA | APOA5 | 116519 | 5 | 50 | 41 |
Total number of gains: 28; Total number of losses: 165; Total Number of normals: 295.
Somatic mutations of APOA5:
Generating mutation plots.
Highly correlated genes for APOA5:
Showing top 20/205 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOA5 | HCN4 | 0.727299 | 3 | 0 | 3 |
| APOA5 | MTUS2-AS1 | 0.7239 | 3 | 0 | 3 |
| APOA5 | LINC00845 | 0.710982 | 3 | 0 | 3 |
| APOA5 | GJB1 | 0.675146 | 3 | 0 | 3 |
| APOA5 | MUC8 | 0.673622 | 3 | 0 | 3 |
| APOA5 | MSANTD1 | 0.673391 | 3 | 0 | 3 |
| APOA5 | WNT16 | 0.671947 | 3 | 0 | 3 |
| APOA5 | ZNF295-AS1 | 0.670415 | 4 | 0 | 3 |
| APOA5 | CSMD2-AS1 | 0.661763 | 3 | 0 | 3 |
| APOA5 | ZFHX2 | 0.659445 | 3 | 0 | 3 |
| APOA5 | MAPT-AS1 | 0.658167 | 4 | 0 | 4 |
| APOA5 | OPN4 | 0.657481 | 4 | 0 | 4 |
| APOA5 | CCDC33 | 0.656333 | 4 | 0 | 3 |
| APOA5 | MAPK12 | 0.652793 | 3 | 0 | 3 |
| APOA5 | LINC01210 | 0.651069 | 4 | 0 | 3 |
| APOA5 | C11orf16 | 0.647783 | 3 | 0 | 3 |
| APOA5 | SSMEM1 | 0.644168 | 3 | 0 | 3 |
| APOA5 | NKD1 | 0.643378 | 3 | 0 | 3 |
| APOA5 | VGLL2 | 0.642738 | 4 | 0 | 3 |
| APOA5 | LINC00410 | 0.642545 | 3 | 0 | 3 |
For details and further investigation, click here
