| Full name: pyruvate kinase L/R | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 5313 | HGNC ID: HGNC:9020 | Ensembl Gene: ENSG00000143627 | OMIM ID: 609712 |
| Drug and gene relationship at DGIdb | |||
PKLR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway | |
| hsa04930 | Type II diabetes mellitus | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | |
| hsa04950 | Maturity onset diabetes of the young |
Expression of PKLR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKLR | 5313 | 210451_at | 0.1785 | 0.6948 | |
| GSE20347 | PKLR | 5313 | 222078_at | -0.0286 | 0.6044 | |
| GSE23400 | PKLR | 5313 | 210451_at | -0.1289 | 0.0102 | |
| GSE26886 | PKLR | 5313 | 222078_at | 0.1320 | 0.1682 | |
| GSE29001 | PKLR | 5313 | 210451_at | -0.1511 | 0.5168 | |
| GSE38129 | PKLR | 5313 | 222078_at | -0.0920 | 0.0943 | |
| GSE45670 | PKLR | 5313 | 222078_at | 0.0929 | 0.3362 | |
| GSE53622 | PKLR | 5313 | 92846 | 0.3739 | 0.0004 | |
| GSE53624 | PKLR | 5313 | 92846 | 0.2031 | 0.0162 | |
| GSE63941 | PKLR | 5313 | 222078_at | 0.0671 | 0.6638 | |
| GSE77861 | PKLR | 5313 | 222078_at | -0.1931 | 0.2195 | |
| GSE97050 | PKLR | 5313 | A_23_P201022 | -0.0328 | 0.8870 | |
| TCGA | PKLR | 5313 | RNAseq | 2.9105 | 0.0024 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PKLR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKLR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKLR | 5313 | 14 | 0 | 16 | |
| GSE20123 | PKLR | 5313 | 13 | 0 | 17 | |
| GSE43470 | PKLR | 5313 | 7 | 3 | 33 | |
| GSE46452 | PKLR | 5313 | 2 | 1 | 56 | |
| GSE47630 | PKLR | 5313 | 14 | 0 | 26 | |
| GSE54993 | PKLR | 5313 | 0 | 4 | 66 | |
| GSE54994 | PKLR | 5313 | 16 | 0 | 37 | |
| GSE60625 | PKLR | 5313 | 0 | 0 | 11 | |
| GSE74703 | PKLR | 5313 | 7 | 2 | 27 | |
| GSE74704 | PKLR | 5313 | 6 | 0 | 14 | |
| TCGA | PKLR | 5313 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.
Somatic mutations of PKLR:
Generating mutation plots.
Highly correlated genes for PKLR:
Showing top 20/1116 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKLR | ADAM21 | 0.877477 | 3 | 0 | 3 |
| PKLR | LIPE-AS1 | 0.840569 | 3 | 0 | 3 |
| PKLR | ZNF329 | 0.820035 | 3 | 0 | 3 |
| PKLR | IGFN1 | 0.792987 | 3 | 0 | 3 |
| PKLR | MRGPRG | 0.790446 | 3 | 0 | 3 |
| PKLR | C2CD4D | 0.789387 | 3 | 0 | 3 |
| PKLR | C9orf153 | 0.7827 | 3 | 0 | 3 |
| PKLR | SCARF2 | 0.779603 | 3 | 0 | 3 |
| PKLR | CATSPER3 | 0.777098 | 3 | 0 | 3 |
| PKLR | QRFP | 0.768401 | 3 | 0 | 3 |
| PKLR | STRC | 0.768008 | 3 | 0 | 3 |
| PKLR | OR5A1 | 0.764114 | 3 | 0 | 3 |
| PKLR | YY2 | 0.761893 | 3 | 0 | 3 |
| PKLR | SLCO1A2 | 0.760562 | 3 | 0 | 3 |
| PKLR | DMC1 | 0.760113 | 4 | 0 | 4 |
| PKLR | C1QL2 | 0.757343 | 3 | 0 | 3 |
| PKLR | SLC25A47 | 0.757292 | 3 | 0 | 3 |
| PKLR | DCDC1 | 0.756878 | 3 | 0 | 3 |
| PKLR | C7orf61 | 0.756145 | 4 | 0 | 4 |
| PKLR | KRTAP3-1 | 0.755622 | 3 | 0 | 3 |
For details and further investigation, click here
