| Full name: solute carrier organic anion transporter family member 1A2 | Alias Symbol: OATP|OATP1A2|OATP-A | ||
| Type: protein-coding gene | Cytoband: 12p12.1 | ||
| Entrez ID: 6579 | HGNC ID: HGNC:10956 | Ensembl Gene: ENSG00000084453 | OMIM ID: 602883 |
| Drug and gene relationship at DGIdb | |||
SLCO1A2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04976 | Bile secretion |
Expression of SLCO1A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLCO1A2 | 6579 | 211481_at | -0.0947 | 0.7190 | |
| GSE20347 | SLCO1A2 | 6579 | 211481_at | 0.3347 | 0.0044 | |
| GSE23400 | SLCO1A2 | 6579 | 211481_at | -0.0932 | 0.0403 | |
| GSE26886 | SLCO1A2 | 6579 | 211480_s_at | 0.8911 | 0.0238 | |
| GSE29001 | SLCO1A2 | 6579 | 211480_s_at | 0.1468 | 0.4065 | |
| GSE38129 | SLCO1A2 | 6579 | 211481_at | 0.1500 | 0.1825 | |
| GSE45670 | SLCO1A2 | 6579 | 211480_s_at | 1.1380 | 0.0007 | |
| GSE53622 | SLCO1A2 | 6579 | 59505 | 0.9585 | 0.0000 | |
| GSE53624 | SLCO1A2 | 6579 | 59505 | 0.6263 | 0.0000 | |
| GSE63941 | SLCO1A2 | 6579 | 211480_s_at | 1.0633 | 0.1996 | |
| GSE77861 | SLCO1A2 | 6579 | 211480_s_at | 0.3809 | 0.2981 | |
| GSE97050 | SLCO1A2 | 6579 | A_33_P3236297 | 0.2174 | 0.3376 | |
| SRP007169 | SLCO1A2 | 6579 | RNAseq | 4.8231 | 0.0000 | |
| SRP008496 | SLCO1A2 | 6579 | RNAseq | 4.5655 | 0.0000 | |
| SRP133303 | SLCO1A2 | 6579 | RNAseq | 3.6110 | 0.0000 | |
| SRP159526 | SLCO1A2 | 6579 | RNAseq | 6.8493 | 0.0000 | |
| TCGA | SLCO1A2 | 6579 | RNAseq | 2.2765 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by SLCO1A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLCO1A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLCO1A2 | 6579 | 9 | 2 | 19 | |
| GSE20123 | SLCO1A2 | 6579 | 9 | 2 | 19 | |
| GSE43470 | SLCO1A2 | 6579 | 9 | 4 | 30 | |
| GSE46452 | SLCO1A2 | 6579 | 10 | 1 | 48 | |
| GSE47630 | SLCO1A2 | 6579 | 14 | 1 | 25 | |
| GSE54993 | SLCO1A2 | 6579 | 1 | 9 | 60 | |
| GSE54994 | SLCO1A2 | 6579 | 11 | 2 | 40 | |
| GSE60625 | SLCO1A2 | 6579 | 0 | 1 | 10 | |
| GSE74703 | SLCO1A2 | 6579 | 9 | 3 | 24 | |
| GSE74704 | SLCO1A2 | 6579 | 6 | 1 | 13 | |
| TCGA | SLCO1A2 | 6579 | 42 | 6 | 48 |
Total number of gains: 120; Total number of losses: 32; Total Number of normals: 336.
Somatic mutations of SLCO1A2:
Generating mutation plots.
Highly correlated genes for SLCO1A2:
Showing top 20/294 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLCO1A2 | OR56A5 | 0.812564 | 3 | 0 | 3 |
| SLCO1A2 | HPR | 0.767704 | 4 | 0 | 4 |
| SLCO1A2 | PKLR | 0.760562 | 3 | 0 | 3 |
| SLCO1A2 | OR2D3 | 0.760413 | 3 | 0 | 3 |
| SLCO1A2 | SLC5A4 | 0.736911 | 4 | 0 | 4 |
| SLCO1A2 | OR4A15 | 0.733181 | 3 | 0 | 3 |
| SLCO1A2 | MYBPH | 0.729193 | 3 | 0 | 3 |
| SLCO1A2 | OR2G2 | 0.723675 | 3 | 0 | 3 |
| SLCO1A2 | HOXC9 | 0.7224 | 4 | 0 | 3 |
| SLCO1A2 | CLDN14 | 0.721539 | 3 | 0 | 3 |
| SLCO1A2 | LRTM1 | 0.716045 | 3 | 0 | 3 |
| SLCO1A2 | IL9R | 0.705876 | 3 | 0 | 3 |
| SLCO1A2 | TMEM59L | 0.704467 | 3 | 0 | 3 |
| SLCO1A2 | CIB3 | 0.702883 | 3 | 0 | 3 |
| SLCO1A2 | CYP17A1 | 0.702408 | 3 | 0 | 3 |
| SLCO1A2 | KIAA0087 | 0.699724 | 3 | 0 | 3 |
| SLCO1A2 | ANKRD45 | 0.696847 | 3 | 0 | 3 |
| SLCO1A2 | STXBP6 | 0.684554 | 3 | 0 | 3 |
| SLCO1A2 | OR2H2 | 0.683932 | 4 | 0 | 3 |
| SLCO1A2 | SHANK1 | 0.679051 | 3 | 0 | 3 |
For details and further investigation, click here
