| Full name: ADAM metallopeptidase domain 21 | Alias Symbol: ADAM31 | ||
| Type: protein-coding gene | Cytoband: 14q24.2 | ||
| Entrez ID: 8747 | HGNC ID: HGNC:200 | Ensembl Gene: ENSG00000139985 | OMIM ID: 603713 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAM21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAM21 | 8747 | 1552579_a_at | 0.3101 | 0.2054 | |
| GSE20347 | ADAM21 | 8747 | 207665_at | 0.0789 | 0.2224 | |
| GSE23400 | ADAM21 | 8747 | 207665_at | -0.0733 | 0.0334 | |
| GSE26886 | ADAM21 | 8747 | 1552579_a_at | -0.2533 | 0.0237 | |
| GSE29001 | ADAM21 | 8747 | 207665_at | -0.0204 | 0.9390 | |
| GSE38129 | ADAM21 | 8747 | 207665_at | 0.0605 | 0.2838 | |
| GSE45670 | ADAM21 | 8747 | 1552579_a_at | 0.1202 | 0.2519 | |
| GSE53622 | ADAM21 | 8747 | 70465 | 0.7342 | 0.0000 | |
| GSE53624 | ADAM21 | 8747 | 70465 | 0.2893 | 0.0005 | |
| GSE63941 | ADAM21 | 8747 | 1552579_a_at | -0.2484 | 0.3107 | |
| GSE77861 | ADAM21 | 8747 | 1552579_a_at | -0.0781 | 0.4475 | |
| GSE97050 | ADAM21 | 8747 | A_23_P367420 | 0.1706 | 0.3789 | |
| SRP133303 | ADAM21 | 8747 | RNAseq | -0.0544 | 0.8744 | |
| TCGA | ADAM21 | 8747 | RNAseq | -0.7155 | 0.0853 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ADAM21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAM21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAM21 | 8747 | 8 | 3 | 19 | |
| GSE20123 | ADAM21 | 8747 | 8 | 3 | 19 | |
| GSE43470 | ADAM21 | 8747 | 8 | 3 | 32 | |
| GSE46452 | ADAM21 | 8747 | 16 | 3 | 40 | |
| GSE47630 | ADAM21 | 8747 | 11 | 9 | 20 | |
| GSE54993 | ADAM21 | 8747 | 3 | 9 | 58 | |
| GSE54994 | ADAM21 | 8747 | 18 | 5 | 30 | |
| GSE60625 | ADAM21 | 8747 | 0 | 2 | 9 | |
| GSE74703 | ADAM21 | 8747 | 7 | 3 | 26 | |
| GSE74704 | ADAM21 | 8747 | 3 | 3 | 14 | |
| TCGA | ADAM21 | 8747 | 32 | 16 | 48 |
Total number of gains: 114; Total number of losses: 59; Total Number of normals: 315.
Somatic mutations of ADAM21:
Generating mutation plots.
Highly correlated genes for ADAM21:
Showing top 20/431 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAM21 | PKLR | 0.877477 | 3 | 0 | 3 |
| ADAM21 | DMC1 | 0.813585 | 3 | 0 | 3 |
| ADAM21 | CHD5 | 0.78928 | 3 | 0 | 3 |
| ADAM21 | PCYT2 | 0.777504 | 3 | 0 | 3 |
| ADAM21 | ZWINT | 0.764584 | 3 | 0 | 3 |
| ADAM21 | ZNF81 | 0.750636 | 3 | 0 | 3 |
| ADAM21 | STK11 | 0.7449 | 3 | 0 | 3 |
| ADAM21 | TP53TG5 | 0.737932 | 3 | 0 | 3 |
| ADAM21 | CHRNB4 | 0.728146 | 3 | 0 | 3 |
| ADAM21 | F2 | 0.726903 | 3 | 0 | 3 |
| ADAM21 | HOXB6 | 0.718373 | 3 | 0 | 3 |
| ADAM21 | CADPS | 0.714757 | 4 | 0 | 3 |
| ADAM21 | GFRA2 | 0.714523 | 4 | 0 | 4 |
| ADAM21 | ALAS2 | 0.714013 | 3 | 0 | 3 |
| ADAM21 | GC | 0.711827 | 3 | 0 | 3 |
| ADAM21 | FOXN3-AS2 | 0.711633 | 4 | 0 | 4 |
| ADAM21 | KRT38 | 0.710123 | 3 | 0 | 3 |
| ADAM21 | AFP | 0.708776 | 3 | 0 | 3 |
| ADAM21 | NCR3 | 0.706644 | 4 | 0 | 3 |
| ADAM21 | TBX4 | 0.706306 | 4 | 0 | 3 |
For details and further investigation, click here
