| Full name: DNA meiotic recombinase 1 | Alias Symbol: LIM15 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 11144 | HGNC ID: HGNC:2927 | Ensembl Gene: ENSG00000100206 | OMIM ID: 602721 |
| Drug and gene relationship at DGIdb | |||
Expression of DMC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DMC1 | 11144 | 208386_x_at | 0.1555 | 0.6884 | |
| GSE20347 | DMC1 | 11144 | 208382_s_at | -0.0165 | 0.8020 | |
| GSE23400 | DMC1 | 11144 | 208382_s_at | -0.0998 | 0.0072 | |
| GSE26886 | DMC1 | 11144 | 208382_s_at | -0.0814 | 0.3928 | |
| GSE29001 | DMC1 | 11144 | 208382_s_at | -0.0963 | 0.5969 | |
| GSE38129 | DMC1 | 11144 | 208382_s_at | -0.0656 | 0.3276 | |
| GSE45670 | DMC1 | 11144 | 208386_x_at | 0.1030 | 0.2717 | |
| GSE53622 | DMC1 | 11144 | 12400 | -0.0794 | 0.2540 | |
| GSE53624 | DMC1 | 11144 | 12400 | 0.0505 | 0.5627 | |
| GSE63941 | DMC1 | 11144 | 208382_s_at | 0.4080 | 0.4763 | |
| GSE77861 | DMC1 | 11144 | 208386_x_at | -0.0077 | 0.9575 | |
| GSE97050 | DMC1 | 11144 | A_23_P361381 | -0.0949 | 0.7318 | |
| SRP007169 | DMC1 | 11144 | RNAseq | 1.0864 | 0.1646 | |
| SRP133303 | DMC1 | 11144 | RNAseq | 0.4754 | 0.2553 | |
| SRP159526 | DMC1 | 11144 | RNAseq | 1.7927 | 0.0112 | |
| SRP193095 | DMC1 | 11144 | RNAseq | 0.6018 | 0.0118 | |
| SRP219564 | DMC1 | 11144 | RNAseq | -0.1387 | 0.8627 | |
| TCGA | DMC1 | 11144 | RNAseq | 1.7033 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DMC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DMC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DMC1 | 11144 | 6 | 5 | 19 | |
| GSE20123 | DMC1 | 11144 | 6 | 4 | 20 | |
| GSE43470 | DMC1 | 11144 | 5 | 5 | 33 | |
| GSE46452 | DMC1 | 11144 | 32 | 2 | 25 | |
| GSE47630 | DMC1 | 11144 | 9 | 4 | 27 | |
| GSE54993 | DMC1 | 11144 | 3 | 6 | 61 | |
| GSE54994 | DMC1 | 11144 | 9 | 7 | 37 | |
| GSE60625 | DMC1 | 11144 | 5 | 0 | 6 | |
| GSE74703 | DMC1 | 11144 | 5 | 4 | 27 | |
| GSE74704 | DMC1 | 11144 | 3 | 2 | 15 | |
| TCGA | DMC1 | 11144 | 28 | 15 | 53 |
Total number of gains: 111; Total number of losses: 54; Total Number of normals: 323.
Somatic mutations of DMC1:
Generating mutation plots.
Highly correlated genes for DMC1:
Showing top 20/170 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DMC1 | ADAM21 | 0.813585 | 3 | 0 | 3 |
| DMC1 | CCDC142 | 0.782752 | 3 | 0 | 3 |
| DMC1 | ACSBG2 | 0.771665 | 3 | 0 | 3 |
| DMC1 | OBSL1 | 0.769511 | 3 | 0 | 3 |
| DMC1 | C3orf36 | 0.764731 | 3 | 0 | 3 |
| DMC1 | USP49 | 0.763785 | 4 | 0 | 3 |
| DMC1 | FOLH1 | 0.762201 | 3 | 0 | 3 |
| DMC1 | PKLR | 0.760113 | 4 | 0 | 4 |
| DMC1 | KRT35 | 0.755436 | 3 | 0 | 3 |
| DMC1 | SPTA1 | 0.752523 | 3 | 0 | 3 |
| DMC1 | TDRD1 | 0.746584 | 4 | 0 | 4 |
| DMC1 | PTPRN2 | 0.745123 | 3 | 0 | 3 |
| DMC1 | TNNT2 | 0.744883 | 3 | 0 | 3 |
| DMC1 | MAGEA8 | 0.733938 | 3 | 0 | 3 |
| DMC1 | FCAR | 0.732722 | 3 | 0 | 3 |
| DMC1 | DAB1 | 0.72823 | 4 | 0 | 3 |
| DMC1 | RNF17 | 0.727333 | 3 | 0 | 3 |
| DMC1 | UPB1 | 0.725247 | 3 | 0 | 3 |
| DMC1 | IL19 | 0.717846 | 3 | 0 | 3 |
| DMC1 | BMP8B | 0.710812 | 4 | 0 | 3 |
For details and further investigation, click here
