| Full name: Ral GTPase activating protein catalytic alpha subunit 1 | Alias Symbol: GRIPE|DKFZp667F074|KIAA0884|Tulip1|RalGAPalpha1 | ||
| Type: protein-coding gene | Cytoband: 14q13.2 | ||
| Entrez ID: 253959 | HGNC ID: HGNC:17770 | Ensembl Gene: ENSG00000174373 | OMIM ID: 608884 |
| Drug and gene relationship at DGIdb | |||
Expression of RALGAPA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RALGAPA1 | 253959 | 213049_at | -0.2179 | 0.8113 | |
| GSE20347 | RALGAPA1 | 253959 | 213049_at | -0.3863 | 0.1080 | |
| GSE23400 | RALGAPA1 | 253959 | 213049_at | -0.1495 | 0.1685 | |
| GSE26886 | RALGAPA1 | 253959 | 213049_at | 0.4104 | 0.0842 | |
| GSE29001 | RALGAPA1 | 253959 | 213049_at | -0.3304 | 0.1462 | |
| GSE38129 | RALGAPA1 | 253959 | 213049_at | -0.5230 | 0.0034 | |
| GSE45670 | RALGAPA1 | 253959 | 213049_at | -0.5068 | 0.0016 | |
| GSE53622 | RALGAPA1 | 253959 | 20755 | -0.4805 | 0.0000 | |
| GSE53624 | RALGAPA1 | 253959 | 20755 | -0.6012 | 0.0000 | |
| GSE63941 | RALGAPA1 | 253959 | 213049_at | 0.3906 | 0.5794 | |
| GSE77861 | RALGAPA1 | 253959 | 213049_at | 0.1641 | 0.7787 | |
| GSE97050 | RALGAPA1 | 253959 | A_24_P918843 | -0.0360 | 0.8983 | |
| SRP007169 | RALGAPA1 | 253959 | RNAseq | 0.0604 | 0.8791 | |
| SRP008496 | RALGAPA1 | 253959 | RNAseq | 0.0566 | 0.7930 | |
| SRP064894 | RALGAPA1 | 253959 | RNAseq | -0.6522 | 0.0208 | |
| SRP133303 | RALGAPA1 | 253959 | RNAseq | -0.1975 | 0.2291 | |
| SRP159526 | RALGAPA1 | 253959 | RNAseq | -0.6486 | 0.0075 | |
| SRP193095 | RALGAPA1 | 253959 | RNAseq | -0.4894 | 0.0000 | |
| SRP219564 | RALGAPA1 | 253959 | RNAseq | -0.5138 | 0.2031 | |
| TCGA | RALGAPA1 | 253959 | RNAseq | -0.1747 | 0.0059 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RALGAPA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RALGAPA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RALGAPA1 | 253959 | 11 | 4 | 15 | |
| GSE20123 | RALGAPA1 | 253959 | 12 | 4 | 14 | |
| GSE43470 | RALGAPA1 | 253959 | 9 | 3 | 31 | |
| GSE46452 | RALGAPA1 | 253959 | 18 | 2 | 39 | |
| GSE47630 | RALGAPA1 | 253959 | 12 | 9 | 19 | |
| GSE54993 | RALGAPA1 | 253959 | 3 | 10 | 57 | |
| GSE54994 | RALGAPA1 | 253959 | 19 | 5 | 29 | |
| GSE60625 | RALGAPA1 | 253959 | 0 | 2 | 9 | |
| GSE74703 | RALGAPA1 | 253959 | 8 | 3 | 25 | |
| GSE74704 | RALGAPA1 | 253959 | 6 | 3 | 11 | |
| TCGA | RALGAPA1 | 253959 | 34 | 15 | 47 |
Total number of gains: 132; Total number of losses: 60; Total Number of normals: 296.
Somatic mutations of RALGAPA1:
Generating mutation plots.
Highly correlated genes for RALGAPA1:
Showing top 20/332 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RALGAPA1 | ACBD5 | 0.783947 | 3 | 0 | 3 |
| RALGAPA1 | NAA35 | 0.778961 | 3 | 0 | 3 |
| RALGAPA1 | COPS4 | 0.770238 | 3 | 0 | 3 |
| RALGAPA1 | LUC7L2 | 0.766796 | 3 | 0 | 3 |
| RALGAPA1 | CEP192 | 0.73717 | 3 | 0 | 3 |
| RALGAPA1 | TIGD1 | 0.734897 | 3 | 0 | 3 |
| RALGAPA1 | HSBP1 | 0.729834 | 3 | 0 | 3 |
| RALGAPA1 | ZFP90 | 0.724241 | 3 | 0 | 3 |
| RALGAPA1 | MTO1 | 0.718439 | 3 | 0 | 3 |
| RALGAPA1 | SLC35A5 | 0.712657 | 3 | 0 | 3 |
| RALGAPA1 | MIPOL1 | 0.708732 | 6 | 0 | 5 |
| RALGAPA1 | NPHP3 | 0.707594 | 3 | 0 | 3 |
| RALGAPA1 | TMEM128 | 0.703939 | 3 | 0 | 3 |
| RALGAPA1 | ZNF613 | 0.702636 | 4 | 0 | 3 |
| RALGAPA1 | PUM1 | 0.700942 | 4 | 0 | 3 |
| RALGAPA1 | NUBPL | 0.693791 | 5 | 0 | 5 |
| RALGAPA1 | CNOT4 | 0.688396 | 4 | 0 | 3 |
| RALGAPA1 | NDUFA13 | 0.684122 | 3 | 0 | 3 |
| RALGAPA1 | COX7B | 0.680545 | 3 | 0 | 3 |
| RALGAPA1 | FAM102B | 0.674688 | 3 | 0 | 3 |
For details and further investigation, click here
