| Full name: COP9 signalosome subunit 4 | Alias Symbol: CSN4 | ||
| Type: protein-coding gene | Cytoband: 4q21.22 | ||
| Entrez ID: 51138 | HGNC ID: HGNC:16702 | Ensembl Gene: ENSG00000138663 | OMIM ID: 616008 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COPS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPS4 | 51138 | 218042_at | -0.1236 | 0.7491 | |
| GSE20347 | COPS4 | 51138 | 218042_at | -0.3470 | 0.0394 | |
| GSE23400 | COPS4 | 51138 | 218042_at | -0.1764 | 0.0062 | |
| GSE26886 | COPS4 | 51138 | 218042_at | -0.0115 | 0.9655 | |
| GSE29001 | COPS4 | 51138 | 218042_at | -0.4715 | 0.4225 | |
| GSE38129 | COPS4 | 51138 | 218042_at | -0.2210 | 0.0909 | |
| GSE45670 | COPS4 | 51138 | 218042_at | -0.1907 | 0.1083 | |
| GSE53622 | COPS4 | 51138 | 95279 | -0.2139 | 0.0076 | |
| GSE53624 | COPS4 | 51138 | 95279 | -0.2040 | 0.0270 | |
| GSE63941 | COPS4 | 51138 | 218042_at | -0.2244 | 0.5042 | |
| GSE77861 | COPS4 | 51138 | 218042_at | -0.2617 | 0.5998 | |
| GSE97050 | COPS4 | 51138 | A_23_P43779 | -0.1777 | 0.4078 | |
| SRP007169 | COPS4 | 51138 | RNAseq | -0.5718 | 0.1368 | |
| SRP008496 | COPS4 | 51138 | RNAseq | -0.5365 | 0.0247 | |
| SRP064894 | COPS4 | 51138 | RNAseq | -0.4149 | 0.0029 | |
| SRP133303 | COPS4 | 51138 | RNAseq | -0.0345 | 0.8639 | |
| SRP159526 | COPS4 | 51138 | RNAseq | -0.4784 | 0.0029 | |
| SRP193095 | COPS4 | 51138 | RNAseq | -0.5598 | 0.0004 | |
| SRP219564 | COPS4 | 51138 | RNAseq | -0.6236 | 0.0911 | |
| TCGA | COPS4 | 51138 | RNAseq | -0.0196 | 0.6963 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COPS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COPS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPS4 | 51138 | 2 | 11 | 17 | |
| GSE20123 | COPS4 | 51138 | 2 | 11 | 17 | |
| GSE43470 | COPS4 | 51138 | 0 | 13 | 30 | |
| GSE46452 | COPS4 | 51138 | 1 | 36 | 22 | |
| GSE47630 | COPS4 | 51138 | 0 | 20 | 20 | |
| GSE54993 | COPS4 | 51138 | 8 | 0 | 62 | |
| GSE54994 | COPS4 | 51138 | 1 | 9 | 43 | |
| GSE60625 | COPS4 | 51138 | 0 | 0 | 11 | |
| GSE74703 | COPS4 | 51138 | 0 | 11 | 25 | |
| GSE74704 | COPS4 | 51138 | 1 | 6 | 13 | |
| TCGA | COPS4 | 51138 | 12 | 34 | 50 |
Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.
Somatic mutations of COPS4:
Generating mutation plots.
Highly correlated genes for COPS4:
Showing top 20/747 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPS4 | RALGAPA1 | 0.770238 | 3 | 0 | 3 |
| COPS4 | HERPUD1 | 0.7688 | 3 | 0 | 3 |
| COPS4 | SLC12A6 | 0.762879 | 3 | 0 | 3 |
| COPS4 | PTGES3 | 0.756428 | 3 | 0 | 3 |
| COPS4 | EZR | 0.747949 | 3 | 0 | 3 |
| COPS4 | PAIP2 | 0.743973 | 3 | 0 | 3 |
| COPS4 | RNF13 | 0.742807 | 3 | 0 | 3 |
| COPS4 | MDFIC | 0.723205 | 3 | 0 | 3 |
| COPS4 | CHM | 0.713686 | 4 | 0 | 3 |
| COPS4 | SLC25A38 | 0.713307 | 3 | 0 | 3 |
| COPS4 | DERA | 0.708751 | 3 | 0 | 3 |
| COPS4 | METTL9 | 0.70695 | 7 | 0 | 6 |
| COPS4 | CPA3 | 0.701718 | 3 | 0 | 3 |
| COPS4 | WDFY1 | 0.701302 | 3 | 0 | 3 |
| COPS4 | UCHL5 | 0.700455 | 4 | 0 | 3 |
| COPS4 | BTBD1 | 0.699091 | 3 | 0 | 3 |
| COPS4 | ATF6 | 0.697788 | 6 | 0 | 6 |
| COPS4 | SRFBP1 | 0.69563 | 3 | 0 | 3 |
| COPS4 | UBE2E2 | 0.691103 | 3 | 0 | 3 |
| COPS4 | NPAT | 0.691066 | 4 | 0 | 4 |
For details and further investigation, click here
