| Full name: pumilio RNA binding family member 1 | Alias Symbol: PUMH1|KIAA0099 | ||
| Type: protein-coding gene | Cytoband: 1p35.2 | ||
| Entrez ID: 9698 | HGNC ID: HGNC:14957 | Ensembl Gene: ENSG00000134644 | OMIM ID: 607204 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PUM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PUM1 | 9698 | 201166_s_at | 0.0660 | 0.7831 | |
| GSE20347 | PUM1 | 9698 | 201166_s_at | 0.1590 | 0.1465 | |
| GSE23400 | PUM1 | 9698 | 201166_s_at | 0.3145 | 0.0000 | |
| GSE26886 | PUM1 | 9698 | 201166_s_at | 0.2158 | 0.1295 | |
| GSE29001 | PUM1 | 9698 | 201166_s_at | 0.2207 | 0.0365 | |
| GSE38129 | PUM1 | 9698 | 201166_s_at | 0.1685 | 0.0267 | |
| GSE45670 | PUM1 | 9698 | 201166_s_at | 0.0649 | 0.6052 | |
| GSE53622 | PUM1 | 9698 | 2629 | -0.0244 | 0.6156 | |
| GSE53624 | PUM1 | 9698 | 2629 | 0.1066 | 0.0152 | |
| GSE63941 | PUM1 | 9698 | 201166_s_at | 0.1775 | 0.5423 | |
| GSE77861 | PUM1 | 9698 | 201166_s_at | 0.2429 | 0.1540 | |
| GSE97050 | PUM1 | 9698 | A_23_P170820 | -0.1269 | 0.6069 | |
| SRP007169 | PUM1 | 9698 | RNAseq | 0.8696 | 0.0331 | |
| SRP008496 | PUM1 | 9698 | RNAseq | 0.6249 | 0.0272 | |
| SRP064894 | PUM1 | 9698 | RNAseq | 0.1543 | 0.4439 | |
| SRP133303 | PUM1 | 9698 | RNAseq | 0.1585 | 0.0819 | |
| SRP159526 | PUM1 | 9698 | RNAseq | 0.0767 | 0.6489 | |
| SRP193095 | PUM1 | 9698 | RNAseq | 0.0380 | 0.5963 | |
| SRP219564 | PUM1 | 9698 | RNAseq | -0.0159 | 0.9519 | |
| TCGA | PUM1 | 9698 | RNAseq | 0.0485 | 0.2386 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PUM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PUM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PUM1 | 9698 | 0 | 6 | 24 | |
| GSE20123 | PUM1 | 9698 | 0 | 5 | 25 | |
| GSE43470 | PUM1 | 9698 | 3 | 6 | 34 | |
| GSE46452 | PUM1 | 9698 | 5 | 1 | 53 | |
| GSE47630 | PUM1 | 9698 | 8 | 3 | 29 | |
| GSE54993 | PUM1 | 9698 | 1 | 1 | 68 | |
| GSE54994 | PUM1 | 9698 | 10 | 3 | 40 | |
| GSE60625 | PUM1 | 9698 | 0 | 0 | 11 | |
| GSE74703 | PUM1 | 9698 | 2 | 4 | 30 | |
| GSE74704 | PUM1 | 9698 | 0 | 0 | 20 | |
| TCGA | PUM1 | 9698 | 12 | 19 | 65 |
Total number of gains: 41; Total number of losses: 48; Total Number of normals: 399.
Somatic mutations of PUM1:
Generating mutation plots.
Highly correlated genes for PUM1:
Showing top 20/536 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PUM1 | AGPAT4 | 0.845204 | 3 | 0 | 3 |
| PUM1 | ZNF518B | 0.783193 | 3 | 0 | 3 |
| PUM1 | TRIM35 | 0.776877 | 3 | 0 | 3 |
| PUM1 | TPCN2 | 0.750216 | 3 | 0 | 3 |
| PUM1 | TMEM205 | 0.75021 | 3 | 0 | 3 |
| PUM1 | MED14 | 0.738455 | 3 | 0 | 3 |
| PUM1 | ORC2 | 0.736998 | 3 | 0 | 3 |
| PUM1 | ZNF317 | 0.735721 | 3 | 0 | 3 |
| PUM1 | GDAP1 | 0.733458 | 3 | 0 | 3 |
| PUM1 | ULK1 | 0.723455 | 3 | 0 | 3 |
| PUM1 | LSM5 | 0.71924 | 3 | 0 | 3 |
| PUM1 | TRUB1 | 0.718413 | 3 | 0 | 3 |
| PUM1 | HERC4 | 0.71797 | 3 | 0 | 3 |
| PUM1 | RELL2 | 0.715618 | 3 | 0 | 3 |
| PUM1 | TMED8 | 0.708961 | 3 | 0 | 3 |
| PUM1 | ZNF251 | 0.708112 | 3 | 0 | 3 |
| PUM1 | MRPS14 | 0.707901 | 3 | 0 | 3 |
| PUM1 | LRIF1 | 0.705366 | 4 | 0 | 3 |
| PUM1 | C12orf65 | 0.702445 | 3 | 0 | 3 |
| PUM1 | CCT4 | 0.702293 | 4 | 0 | 4 |
For details and further investigation, click here
