| Full name: CCR4-NOT transcription complex subunit 4 | Alias Symbol: CLONE243|NOT4H | ||
| Type: protein-coding gene | Cytoband: 7q33 | ||
| Entrez ID: 4850 | HGNC ID: HGNC:7880 | Ensembl Gene: ENSG00000080802 | OMIM ID: 604911 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CNOT4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNOT4 | 4850 | 203291_at | -0.3021 | 0.5271 | |
| GSE20347 | CNOT4 | 4850 | 203291_at | -0.0252 | 0.8527 | |
| GSE23400 | CNOT4 | 4850 | 203291_at | 0.0952 | 0.1566 | |
| GSE26886 | CNOT4 | 4850 | 203291_at | -0.8482 | 0.0046 | |
| GSE29001 | CNOT4 | 4850 | 203291_at | 0.0350 | 0.8565 | |
| GSE38129 | CNOT4 | 4850 | 203291_at | 0.0382 | 0.7060 | |
| GSE45670 | CNOT4 | 4850 | 203291_at | 0.1929 | 0.1215 | |
| GSE53622 | CNOT4 | 4850 | 37517 | 0.2347 | 0.0006 | |
| GSE53624 | CNOT4 | 4850 | 37517 | 0.2232 | 0.0009 | |
| GSE63941 | CNOT4 | 4850 | 203291_at | -1.0605 | 0.0118 | |
| GSE77861 | CNOT4 | 4850 | 203291_at | 0.1084 | 0.5694 | |
| GSE97050 | CNOT4 | 4850 | A_23_P156993 | -0.1956 | 0.5676 | |
| SRP007169 | CNOT4 | 4850 | RNAseq | 0.0115 | 0.9712 | |
| SRP008496 | CNOT4 | 4850 | RNAseq | 0.1019 | 0.6370 | |
| SRP064894 | CNOT4 | 4850 | RNAseq | -0.0050 | 0.9682 | |
| SRP133303 | CNOT4 | 4850 | RNAseq | 0.1415 | 0.2572 | |
| SRP159526 | CNOT4 | 4850 | RNAseq | -0.1434 | 0.6243 | |
| SRP193095 | CNOT4 | 4850 | RNAseq | 0.0220 | 0.8044 | |
| SRP219564 | CNOT4 | 4850 | RNAseq | -0.3561 | 0.1985 | |
| TCGA | CNOT4 | 4850 | RNAseq | -0.0249 | 0.6292 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CNOT4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNOT4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNOT4 | 4850 | 5 | 2 | 23 | |
| GSE20123 | CNOT4 | 4850 | 5 | 2 | 23 | |
| GSE43470 | CNOT4 | 4850 | 2 | 3 | 38 | |
| GSE46452 | CNOT4 | 4850 | 7 | 2 | 50 | |
| GSE47630 | CNOT4 | 4850 | 7 | 4 | 29 | |
| GSE54993 | CNOT4 | 4850 | 3 | 5 | 62 | |
| GSE54994 | CNOT4 | 4850 | 6 | 8 | 39 | |
| GSE60625 | CNOT4 | 4850 | 0 | 0 | 11 | |
| GSE74703 | CNOT4 | 4850 | 2 | 3 | 31 | |
| GSE74704 | CNOT4 | 4850 | 2 | 2 | 16 | |
| TCGA | CNOT4 | 4850 | 28 | 23 | 45 |
Total number of gains: 67; Total number of losses: 54; Total Number of normals: 367.
Somatic mutations of CNOT4:
Generating mutation plots.
Highly correlated genes for CNOT4:
Showing top 20/352 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNOT4 | SLC37A3 | 0.840113 | 3 | 0 | 3 |
| CNOT4 | STAU2 | 0.838518 | 3 | 0 | 3 |
| CNOT4 | MPP5 | 0.813881 | 3 | 0 | 3 |
| CNOT4 | FNIP1 | 0.805704 | 3 | 0 | 3 |
| CNOT4 | C12orf29 | 0.79908 | 3 | 0 | 3 |
| CNOT4 | CUL2 | 0.786048 | 3 | 0 | 3 |
| CNOT4 | ARL8B | 0.782764 | 4 | 0 | 4 |
| CNOT4 | SLC35B3 | 0.779904 | 3 | 0 | 3 |
| CNOT4 | FBXW2 | 0.772429 | 3 | 0 | 3 |
| CNOT4 | CCNYL1 | 0.768614 | 3 | 0 | 3 |
| CNOT4 | KIAA0556 | 0.768247 | 3 | 0 | 3 |
| CNOT4 | PINK1 | 0.764074 | 4 | 0 | 4 |
| CNOT4 | LGALSL | 0.752718 | 3 | 0 | 3 |
| CNOT4 | PKN2 | 0.751854 | 3 | 0 | 3 |
| CNOT4 | FYCO1 | 0.751143 | 3 | 0 | 3 |
| CNOT4 | KIF1B | 0.749997 | 3 | 0 | 3 |
| CNOT4 | ACAA1 | 0.748698 | 3 | 0 | 3 |
| CNOT4 | MTRF1 | 0.745939 | 3 | 0 | 3 |
| CNOT4 | DCTN2 | 0.745787 | 3 | 0 | 3 |
| CNOT4 | SLC12A6 | 0.745125 | 3 | 0 | 3 |
For details and further investigation, click here
