| Full name: mitochondrial tRNA translation optimization 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q13 | ||
| Entrez ID: 25821 | HGNC ID: HGNC:19261 | Ensembl Gene: ENSG00000135297 | OMIM ID: 614667 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MTO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTO1 | 25821 | 222014_x_at | 0.1458 | 0.6537 | |
| GSE20347 | MTO1 | 25821 | 222014_x_at | 0.0342 | 0.8231 | |
| GSE23400 | MTO1 | 25821 | 222014_x_at | 0.2866 | 0.0007 | |
| GSE26886 | MTO1 | 25821 | 222014_x_at | 0.3092 | 0.1178 | |
| GSE29001 | MTO1 | 25821 | 222014_x_at | 0.0911 | 0.8525 | |
| GSE38129 | MTO1 | 25821 | 222014_x_at | 0.0161 | 0.8764 | |
| GSE45670 | MTO1 | 25821 | 222014_x_at | 0.1481 | 0.1994 | |
| GSE53622 | MTO1 | 25821 | 42139 | -0.0872 | 0.1836 | |
| GSE53624 | MTO1 | 25821 | 73996 | -0.0077 | 0.9304 | |
| GSE63941 | MTO1 | 25821 | 222014_x_at | 0.2780 | 0.5403 | |
| GSE77861 | MTO1 | 25821 | 218716_x_at | 0.1506 | 0.6285 | |
| GSE97050 | MTO1 | 25821 | A_23_P145068 | 0.1558 | 0.5009 | |
| SRP007169 | MTO1 | 25821 | RNAseq | 0.2909 | 0.4239 | |
| SRP008496 | MTO1 | 25821 | RNAseq | 0.0049 | 0.9864 | |
| SRP064894 | MTO1 | 25821 | RNAseq | 0.0451 | 0.7242 | |
| SRP133303 | MTO1 | 25821 | RNAseq | 0.0235 | 0.7486 | |
| SRP159526 | MTO1 | 25821 | RNAseq | -0.1153 | 0.5879 | |
| SRP193095 | MTO1 | 25821 | RNAseq | -0.0148 | 0.8363 | |
| SRP219564 | MTO1 | 25821 | RNAseq | -0.0504 | 0.7721 | |
| TCGA | MTO1 | 25821 | RNAseq | -0.0616 | 0.2645 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MTO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTO1 | 25821 | 1 | 3 | 26 | |
| GSE20123 | MTO1 | 25821 | 1 | 2 | 27 | |
| GSE43470 | MTO1 | 25821 | 3 | 0 | 40 | |
| GSE46452 | MTO1 | 25821 | 2 | 11 | 46 | |
| GSE47630 | MTO1 | 25821 | 8 | 4 | 28 | |
| GSE54993 | MTO1 | 25821 | 3 | 2 | 65 | |
| GSE54994 | MTO1 | 25821 | 8 | 9 | 36 | |
| GSE60625 | MTO1 | 25821 | 0 | 1 | 10 | |
| GSE74703 | MTO1 | 25821 | 3 | 0 | 33 | |
| GSE74704 | MTO1 | 25821 | 0 | 1 | 19 | |
| TCGA | MTO1 | 25821 | 10 | 22 | 64 |
Total number of gains: 39; Total number of losses: 55; Total Number of normals: 394.
Somatic mutations of MTO1:
Generating mutation plots.
Highly correlated genes for MTO1:
Showing top 20/699 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTO1 | ZNF764 | 0.789731 | 3 | 0 | 3 |
| MTO1 | ZNF627 | 0.785157 | 3 | 0 | 3 |
| MTO1 | MORN2 | 0.780049 | 3 | 0 | 3 |
| MTO1 | NEDD1 | 0.777093 | 3 | 0 | 3 |
| MTO1 | SMU1 | 0.771252 | 3 | 0 | 3 |
| MTO1 | RNF13 | 0.757186 | 3 | 0 | 3 |
| MTO1 | PPP2R5E | 0.751688 | 3 | 0 | 3 |
| MTO1 | UBE2L3 | 0.740498 | 4 | 0 | 4 |
| MTO1 | LARP1B | 0.737998 | 3 | 0 | 3 |
| MTO1 | NOL9 | 0.736768 | 3 | 0 | 3 |
| MTO1 | LSM11 | 0.727772 | 3 | 0 | 3 |
| MTO1 | FUS | 0.722943 | 3 | 0 | 3 |
| MTO1 | SCAI | 0.721586 | 3 | 0 | 3 |
| MTO1 | UEVLD | 0.719722 | 3 | 0 | 3 |
| MTO1 | RALGAPA1 | 0.718439 | 3 | 0 | 3 |
| MTO1 | CCP110 | 0.717326 | 5 | 0 | 5 |
| MTO1 | IFT74 | 0.716671 | 4 | 0 | 3 |
| MTO1 | ZNF776 | 0.714352 | 3 | 0 | 3 |
| MTO1 | CCDC15 | 0.714024 | 3 | 0 | 3 |
| MTO1 | PIK3C3 | 0.713037 | 4 | 0 | 4 |
For details and further investigation, click here
