| Full name: heat shock factor binding protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q23.3 | ||
| Entrez ID: 3281 | HGNC ID: HGNC:5203 | Ensembl Gene: ENSG00000230989 | OMIM ID: 604553 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HSBP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSBP1 | 3281 | 200942_s_at | -0.3476 | 0.5217 | |
| GSE20347 | HSBP1 | 3281 | 200942_s_at | -0.4686 | 0.0008 | |
| GSE23400 | HSBP1 | 3281 | 200942_s_at | -0.4176 | 0.0000 | |
| GSE26886 | HSBP1 | 3281 | 200941_at | -0.0033 | 0.9880 | |
| GSE29001 | HSBP1 | 3281 | 200941_at | -0.3583 | 0.1672 | |
| GSE38129 | HSBP1 | 3281 | 200942_s_at | -0.0582 | 0.7655 | |
| GSE45670 | HSBP1 | 3281 | 200942_s_at | 0.0027 | 0.9883 | |
| GSE53622 | HSBP1 | 3281 | 106299 | -0.4782 | 0.0000 | |
| GSE53624 | HSBP1 | 3281 | 106299 | -0.4312 | 0.0000 | |
| GSE63941 | HSBP1 | 3281 | 200942_s_at | 0.7257 | 0.1301 | |
| GSE77861 | HSBP1 | 3281 | 200942_s_at | -0.4151 | 0.0644 | |
| GSE97050 | HSBP1 | 3281 | A_33_P3244181 | -0.0109 | 0.9792 | |
| SRP007169 | HSBP1 | 3281 | RNAseq | -0.8953 | 0.0214 | |
| SRP008496 | HSBP1 | 3281 | RNAseq | -0.6996 | 0.0280 | |
| SRP064894 | HSBP1 | 3281 | RNAseq | -0.7094 | 0.0004 | |
| SRP133303 | HSBP1 | 3281 | RNAseq | -0.1248 | 0.5039 | |
| SRP159526 | HSBP1 | 3281 | RNAseq | -0.2714 | 0.2911 | |
| SRP193095 | HSBP1 | 3281 | RNAseq | -0.7276 | 0.0000 | |
| SRP219564 | HSBP1 | 3281 | RNAseq | -0.8460 | 0.0397 | |
| TCGA | HSBP1 | 3281 | RNAseq | 0.0847 | 0.0680 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSBP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSBP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSBP1 | 3281 | 5 | 4 | 21 | |
| GSE20123 | HSBP1 | 3281 | 4 | 4 | 22 | |
| GSE43470 | HSBP1 | 3281 | 2 | 10 | 31 | |
| GSE46452 | HSBP1 | 3281 | 37 | 2 | 20 | |
| GSE47630 | HSBP1 | 3281 | 11 | 9 | 20 | |
| GSE54993 | HSBP1 | 3281 | 3 | 4 | 63 | |
| GSE54994 | HSBP1 | 3281 | 8 | 10 | 35 | |
| GSE60625 | HSBP1 | 3281 | 4 | 0 | 7 | |
| GSE74703 | HSBP1 | 3281 | 2 | 7 | 27 | |
| GSE74704 | HSBP1 | 3281 | 3 | 2 | 15 | |
| TCGA | HSBP1 | 3281 | 25 | 18 | 53 |
Total number of gains: 104; Total number of losses: 70; Total Number of normals: 314.
Somatic mutations of HSBP1:
Generating mutation plots.
Highly correlated genes for HSBP1:
Showing top 20/1094 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSBP1 | FOPNL | 0.759544 | 3 | 0 | 3 |
| HSBP1 | FBXO36 | 0.749904 | 3 | 0 | 3 |
| HSBP1 | ANKRD37 | 0.736149 | 3 | 0 | 3 |
| HSBP1 | RALGAPA1 | 0.729834 | 3 | 0 | 3 |
| HSBP1 | GPBP1 | 0.722852 | 3 | 0 | 3 |
| HSBP1 | MAP3K8 | 0.721741 | 3 | 0 | 3 |
| HSBP1 | VPS25 | 0.716636 | 6 | 0 | 5 |
| HSBP1 | RTN4IP1 | 0.716401 | 3 | 0 | 3 |
| HSBP1 | PITHD1 | 0.71374 | 4 | 0 | 4 |
| HSBP1 | LSM11 | 0.711853 | 3 | 0 | 3 |
| HSBP1 | TBC1D22B | 0.710923 | 3 | 0 | 3 |
| HSBP1 | GRHL1 | 0.708028 | 4 | 0 | 3 |
| HSBP1 | TWF2 | 0.706828 | 3 | 0 | 3 |
| HSBP1 | ELOVL1 | 0.703984 | 3 | 0 | 3 |
| HSBP1 | NAGK | 0.702029 | 8 | 0 | 8 |
| HSBP1 | ARPC2 | 0.70067 | 8 | 0 | 8 |
| HSBP1 | SH3PXD2A-AS1 | 0.697133 | 3 | 0 | 3 |
| HSBP1 | CCNDBP1 | 0.69704 | 5 | 0 | 5 |
| HSBP1 | ZDHHC21 | 0.696065 | 5 | 0 | 4 |
| HSBP1 | TSPYL4 | 0.695949 | 3 | 0 | 3 |
For details and further investigation, click here
