| Full name: nephrocystin 3 | Alias Symbol: NPH3|KIAA2000|FLJ30691|FLJ36696|MKS7|SLSN3|CFAP31 | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 27031 | HGNC ID: HGNC:7907 | Ensembl Gene: ENSG00000113971 | OMIM ID: 608002 |
| Drug and gene relationship at DGIdb | |||
Expression of NPHP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPHP3 | 27031 | 235410_at | -0.0218 | 0.9785 | |
| GSE26886 | NPHP3 | 27031 | 235410_at | 1.3276 | 0.0002 | |
| GSE45670 | NPHP3 | 27031 | 235410_at | -0.2655 | 0.2116 | |
| GSE63941 | NPHP3 | 27031 | 235410_at | -1.4747 | 0.0122 | |
| GSE77861 | NPHP3 | 27031 | 235432_at | 0.2169 | 0.5312 | |
| GSE97050 | NPHP3 | 27031 | A_33_P3228102 | -0.0307 | 0.8999 | |
| SRP007169 | NPHP3 | 27031 | RNAseq | 0.6933 | 0.0973 | |
| SRP008496 | NPHP3 | 27031 | RNAseq | 0.9300 | 0.0117 | |
| SRP064894 | NPHP3 | 27031 | RNAseq | 0.0662 | 0.7908 | |
| SRP133303 | NPHP3 | 27031 | RNAseq | 0.0951 | 0.6019 | |
| SRP159526 | NPHP3 | 27031 | RNAseq | 0.1257 | 0.7386 | |
| SRP193095 | NPHP3 | 27031 | RNAseq | 0.3036 | 0.0205 | |
| SRP219564 | NPHP3 | 27031 | RNAseq | -0.2494 | 0.3811 | |
| TCGA | NPHP3 | 27031 | RNAseq | -0.0786 | 0.2164 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by NPHP3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NPHP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPHP3 | 27031 | 16 | 0 | 14 | |
| GSE20123 | NPHP3 | 27031 | 16 | 0 | 14 | |
| GSE43470 | NPHP3 | 27031 | 21 | 0 | 22 | |
| GSE46452 | NPHP3 | 27031 | 15 | 4 | 40 | |
| GSE47630 | NPHP3 | 27031 | 18 | 3 | 19 | |
| GSE54993 | NPHP3 | 27031 | 2 | 8 | 60 | |
| GSE54994 | NPHP3 | 27031 | 32 | 3 | 18 | |
| GSE60625 | NPHP3 | 27031 | 0 | 6 | 5 | |
| GSE74703 | NPHP3 | 27031 | 18 | 0 | 18 | |
| GSE74704 | NPHP3 | 27031 | 11 | 0 | 9 | |
| TCGA | NPHP3 | 27031 | 59 | 5 | 32 |
Total number of gains: 208; Total number of losses: 29; Total Number of normals: 251.
Somatic mutations of NPHP3:
Generating mutation plots.
Highly correlated genes for NPHP3:
Showing top 20/316 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPHP3 | UHRF1BP1L | 0.811832 | 3 | 0 | 3 |
| NPHP3 | DIP2A | 0.803703 | 3 | 0 | 3 |
| NPHP3 | PIAS4 | 0.794485 | 3 | 0 | 3 |
| NPHP3 | ALKBH6 | 0.791565 | 3 | 0 | 3 |
| NPHP3 | ST3GAL2 | 0.788561 | 3 | 0 | 3 |
| NPHP3 | SFSWAP | 0.781176 | 3 | 0 | 3 |
| NPHP3 | ANAPC4 | 0.779235 | 3 | 0 | 3 |
| NPHP3 | ANKRD12 | 0.775037 | 3 | 0 | 3 |
| NPHP3 | USP4 | 0.77204 | 3 | 0 | 3 |
| NPHP3 | PSMB1 | 0.770795 | 3 | 0 | 3 |
| NPHP3 | BRAP | 0.770055 | 3 | 0 | 3 |
| NPHP3 | ATF7IP | 0.768849 | 3 | 0 | 3 |
| NPHP3 | NIN | 0.76604 | 3 | 0 | 3 |
| NPHP3 | MRFAP1 | 0.764821 | 3 | 0 | 3 |
| NPHP3 | CDIPT | 0.763347 | 3 | 0 | 3 |
| NPHP3 | MRPL32 | 0.763064 | 3 | 0 | 3 |
| NPHP3 | TTL | 0.761589 | 3 | 0 | 3 |
| NPHP3 | MLH3 | 0.758404 | 3 | 0 | 3 |
| NPHP3 | SGTB | 0.754261 | 3 | 0 | 3 |
| NPHP3 | ELAC2 | 0.753967 | 3 | 0 | 3 |
For details and further investigation, click here
