| Full name: solute carrier family 4 member 8 | Alias Symbol: NBC3 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 9498 | HGNC ID: HGNC:11034 | Ensembl Gene: ENSG00000050438 | OMIM ID: 605024 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC4A8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC4A8 | 9498 | 228175_at | -0.0891 | 0.8332 | |
| GSE20347 | SLC4A8 | 9498 | 207056_s_at | -0.0184 | 0.8376 | |
| GSE23400 | SLC4A8 | 9498 | 207056_s_at | -0.0186 | 0.4347 | |
| GSE26886 | SLC4A8 | 9498 | 228175_at | 0.0661 | 0.7438 | |
| GSE29001 | SLC4A8 | 9498 | 207056_s_at | 0.1101 | 0.4033 | |
| GSE38129 | SLC4A8 | 9498 | 207056_s_at | -0.0317 | 0.6032 | |
| GSE45670 | SLC4A8 | 9498 | 228175_at | 0.1519 | 0.2839 | |
| GSE53622 | SLC4A8 | 9498 | 123710 | 0.6086 | 0.0034 | |
| GSE53624 | SLC4A8 | 9498 | 123710 | -0.0690 | 0.7586 | |
| GSE63941 | SLC4A8 | 9498 | 228175_at | 0.0798 | 0.7865 | |
| GSE77861 | SLC4A8 | 9498 | 228175_at | -0.1073 | 0.3531 | |
| GSE97050 | SLC4A8 | 9498 | A_24_P75680 | 0.1471 | 0.6207 | |
| SRP007169 | SLC4A8 | 9498 | RNAseq | 0.7876 | 0.2987 | |
| SRP064894 | SLC4A8 | 9498 | RNAseq | 0.7264 | 0.0209 | |
| SRP133303 | SLC4A8 | 9498 | RNAseq | -0.0531 | 0.7582 | |
| SRP159526 | SLC4A8 | 9498 | RNAseq | 0.8115 | 0.1924 | |
| SRP193095 | SLC4A8 | 9498 | RNAseq | -0.2297 | 0.4077 | |
| SRP219564 | SLC4A8 | 9498 | RNAseq | 1.3216 | 0.0300 | |
| TCGA | SLC4A8 | 9498 | RNAseq | -0.6074 | 0.0392 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SLC4A8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC4A8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC4A8 | 9498 | 8 | 1 | 21 | |
| GSE20123 | SLC4A8 | 9498 | 8 | 1 | 21 | |
| GSE43470 | SLC4A8 | 9498 | 4 | 0 | 39 | |
| GSE46452 | SLC4A8 | 9498 | 8 | 1 | 50 | |
| GSE47630 | SLC4A8 | 9498 | 11 | 2 | 27 | |
| GSE54993 | SLC4A8 | 9498 | 0 | 5 | 65 | |
| GSE54994 | SLC4A8 | 9498 | 3 | 2 | 48 | |
| GSE60625 | SLC4A8 | 9498 | 0 | 0 | 11 | |
| GSE74703 | SLC4A8 | 9498 | 3 | 0 | 33 | |
| GSE74704 | SLC4A8 | 9498 | 5 | 1 | 14 | |
| TCGA | SLC4A8 | 9498 | 14 | 11 | 71 |
Total number of gains: 64; Total number of losses: 24; Total Number of normals: 400.
Somatic mutations of SLC4A8:
Generating mutation plots.
Highly correlated genes for SLC4A8:
Showing top 20/270 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC4A8 | SPEG | 0.916479 | 3 | 0 | 3 |
| SLC4A8 | SLC36A4 | 0.830332 | 3 | 0 | 3 |
| SLC4A8 | CCDC154 | 0.813458 | 3 | 0 | 3 |
| SLC4A8 | LINC01101 | 0.795588 | 3 | 0 | 3 |
| SLC4A8 | KRTAP10-9 | 0.781784 | 3 | 0 | 3 |
| SLC4A8 | OR2AT4 | 0.7808 | 3 | 0 | 3 |
| SLC4A8 | CDH24 | 0.778145 | 4 | 0 | 3 |
| SLC4A8 | KRTAP10-4 | 0.76697 | 3 | 0 | 3 |
| SLC4A8 | COX10-AS1 | 0.75987 | 3 | 0 | 3 |
| SLC4A8 | KIR3DL2 | 0.756305 | 3 | 0 | 3 |
| SLC4A8 | ALG11 | 0.753909 | 3 | 0 | 3 |
| SLC4A8 | MACROD2 | 0.753192 | 3 | 0 | 3 |
| SLC4A8 | ZNF445 | 0.753005 | 3 | 0 | 3 |
| SLC4A8 | OR1L6 | 0.750356 | 3 | 0 | 3 |
| SLC4A8 | RBM17 | 0.750183 | 4 | 0 | 4 |
| SLC4A8 | BARHL1 | 0.743574 | 4 | 0 | 3 |
| SLC4A8 | GBP2 | 0.738855 | 3 | 0 | 3 |
| SLC4A8 | SFTPA2 | 0.738778 | 3 | 0 | 3 |
| SLC4A8 | TMEM150A | 0.738475 | 3 | 0 | 3 |
| SLC4A8 | OR2T33 | 0.725546 | 4 | 0 | 3 |
For details and further investigation, click here
