| Full name: guanylate binding protein 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p22.2 | ||
| Entrez ID: 2634 | HGNC ID: HGNC:4183 | Ensembl Gene: ENSG00000162645 | OMIM ID: 600412 |
| Drug and gene relationship at DGIdb | |||
Expression of GBP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GBP2 | 2634 | 202748_at | -0.4358 | 0.5416 | |
| GSE20347 | GBP2 | 2634 | 202748_at | -0.7113 | 0.0213 | |
| GSE23400 | GBP2 | 2634 | 202748_at | -0.2480 | 0.0637 | |
| GSE26886 | GBP2 | 2634 | 202748_at | -0.1955 | 0.7164 | |
| GSE29001 | GBP2 | 2634 | 202748_at | -0.3624 | 0.5752 | |
| GSE38129 | GBP2 | 2634 | 202748_at | -0.7873 | 0.0004 | |
| GSE45670 | GBP2 | 2634 | 202748_at | 0.0254 | 0.9499 | |
| GSE53622 | GBP2 | 2634 | 48915 | -0.3185 | 0.0064 | |
| GSE53624 | GBP2 | 2634 | 48915 | -0.2847 | 0.0011 | |
| GSE63941 | GBP2 | 2634 | 202748_at | -2.5573 | 0.0247 | |
| GSE77861 | GBP2 | 2634 | 202748_at | -0.5347 | 0.1843 | |
| GSE97050 | GBP2 | 2634 | A_23_P85693 | -0.2280 | 0.3384 | |
| SRP007169 | GBP2 | 2634 | RNAseq | -0.7047 | 0.1618 | |
| SRP008496 | GBP2 | 2634 | RNAseq | -0.7093 | 0.0168 | |
| SRP064894 | GBP2 | 2634 | RNAseq | 0.1369 | 0.5664 | |
| SRP133303 | GBP2 | 2634 | RNAseq | -0.0243 | 0.9453 | |
| SRP159526 | GBP2 | 2634 | RNAseq | -0.5463 | 0.4022 | |
| SRP193095 | GBP2 | 2634 | RNAseq | 0.1038 | 0.5672 | |
| SRP219564 | GBP2 | 2634 | RNAseq | 0.1724 | 0.6979 | |
| TCGA | GBP2 | 2634 | RNAseq | 0.0097 | 0.9256 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GBP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GBP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GBP2 | 2634 | 0 | 8 | 22 | |
| GSE20123 | GBP2 | 2634 | 0 | 8 | 22 | |
| GSE43470 | GBP2 | 2634 | 2 | 4 | 37 | |
| GSE46452 | GBP2 | 2634 | 1 | 1 | 57 | |
| GSE47630 | GBP2 | 2634 | 8 | 5 | 27 | |
| GSE54993 | GBP2 | 2634 | 0 | 1 | 69 | |
| GSE54994 | GBP2 | 2634 | 6 | 2 | 45 | |
| GSE60625 | GBP2 | 2634 | 0 | 0 | 11 | |
| GSE74703 | GBP2 | 2634 | 1 | 3 | 32 | |
| GSE74704 | GBP2 | 2634 | 0 | 5 | 15 | |
| TCGA | GBP2 | 2634 | 6 | 23 | 67 |
Total number of gains: 24; Total number of losses: 60; Total Number of normals: 404.
Somatic mutations of GBP2:
Generating mutation plots.
Highly correlated genes for GBP2:
Showing top 20/392 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GBP2 | CYP27A1 | 0.74035 | 3 | 0 | 3 |
| GBP2 | SLC4A8 | 0.738855 | 3 | 0 | 3 |
| GBP2 | RALGAPA2 | 0.703609 | 3 | 0 | 3 |
| GBP2 | ANGPTL6 | 0.689965 | 3 | 0 | 3 |
| GBP2 | CDC42EP5 | 0.684888 | 3 | 0 | 3 |
| GBP2 | TOP2B | 0.68236 | 3 | 0 | 3 |
| GBP2 | RBM20 | 0.677878 | 3 | 0 | 3 |
| GBP2 | OXR1 | 0.668965 | 3 | 0 | 3 |
| GBP2 | CACNA2D1 | 0.665182 | 4 | 0 | 3 |
| GBP2 | C11orf58 | 0.655744 | 3 | 0 | 3 |
| GBP2 | HIBCH | 0.647749 | 3 | 0 | 3 |
| GBP2 | DCP1A | 0.646471 | 3 | 0 | 3 |
| GBP2 | MRGPRF | 0.643912 | 3 | 0 | 3 |
| GBP2 | XRN1 | 0.638301 | 4 | 0 | 4 |
| GBP2 | APOL1 | 0.637154 | 3 | 0 | 3 |
| GBP2 | GBP3 | 0.635644 | 5 | 0 | 4 |
| GBP2 | DAPK1 | 0.633135 | 4 | 0 | 3 |
| GBP2 | SLC46A3 | 0.632604 | 7 | 0 | 6 |
| GBP2 | RBM6 | 0.631791 | 7 | 0 | 6 |
| GBP2 | FBXO9 | 0.628184 | 5 | 0 | 3 |
For details and further investigation, click here
