| Full name: striated muscle enriched protein kinase | Alias Symbol: MGC12676|KIAA1297|SPEGalpha|SPEGbeta|BPEG|MYLK6 | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 10290 | HGNC ID: HGNC:16901 | Ensembl Gene: ENSG00000072195 | OMIM ID: 615950 |
| Drug and gene relationship at DGIdb | |||
Expression of SPEG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SPEG | 10290 | 9579 | 0.2886 | 0.1092 | |
| GSE53624 | SPEG | 10290 | 9579 | -0.0607 | 0.7083 | |
| GSE97050 | SPEG | 10290 | A_33_P3383696 | -0.5743 | 0.1270 | |
| SRP007169 | SPEG | 10290 | RNAseq | 4.7715 | 0.0001 | |
| SRP064894 | SPEG | 10290 | RNAseq | -0.7114 | 0.0039 | |
| SRP133303 | SPEG | 10290 | RNAseq | -0.4365 | 0.4163 | |
| SRP159526 | SPEG | 10290 | RNAseq | -0.7380 | 0.0420 | |
| SRP193095 | SPEG | 10290 | RNAseq | 1.5971 | 0.0000 | |
| SRP219564 | SPEG | 10290 | RNAseq | -0.6222 | 0.5027 | |
| TCGA | SPEG | 10290 | RNAseq | -0.2235 | 0.2006 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPEG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPEG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPEG | 10290 | 2 | 14 | 14 | |
| GSE20123 | SPEG | 10290 | 2 | 13 | 15 | |
| GSE43470 | SPEG | 10290 | 1 | 6 | 36 | |
| GSE46452 | SPEG | 10290 | 0 | 5 | 54 | |
| GSE47630 | SPEG | 10290 | 4 | 5 | 31 | |
| GSE54993 | SPEG | 10290 | 1 | 2 | 67 | |
| GSE54994 | SPEG | 10290 | 8 | 9 | 36 | |
| GSE60625 | SPEG | 10290 | 0 | 3 | 8 | |
| GSE74703 | SPEG | 10290 | 1 | 5 | 30 | |
| GSE74704 | SPEG | 10290 | 2 | 7 | 11 | |
| TCGA | SPEG | 10290 | 13 | 25 | 58 |
Total number of gains: 34; Total number of losses: 94; Total Number of normals: 360.
Somatic mutations of SPEG:
Generating mutation plots.
Highly correlated genes for SPEG:
Showing top 20/146 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPEG | SLC4A8 | 0.916479 | 3 | 0 | 3 |
| SPEG | CCIN | 0.901857 | 3 | 0 | 3 |
| SPEG | GRIA4 | 0.848755 | 3 | 0 | 3 |
| SPEG | KRTAP10-9 | 0.84473 | 3 | 0 | 3 |
| SPEG | RBM17 | 0.842653 | 3 | 0 | 3 |
| SPEG | ZC3H18 | 0.842111 | 3 | 0 | 3 |
| SPEG | CCDC154 | 0.837938 | 3 | 0 | 3 |
| SPEG | CDH24 | 0.834464 | 4 | 0 | 4 |
| SPEG | CTPS2 | 0.826215 | 3 | 0 | 3 |
| SPEG | CELA3A | 0.824469 | 3 | 0 | 3 |
| SPEG | OR1L6 | 0.819812 | 3 | 0 | 3 |
| SPEG | ZNF248 | 0.813978 | 3 | 0 | 3 |
| SPEG | ZNF445 | 0.813692 | 3 | 0 | 3 |
| SPEG | SZT2 | 0.811563 | 3 | 0 | 3 |
| SPEG | SLC36A4 | 0.794209 | 3 | 0 | 3 |
| SPEG | KRTAP12-2 | 0.793983 | 3 | 0 | 3 |
| SPEG | PLXNB3 | 0.793758 | 3 | 0 | 3 |
| SPEG | BARHL1 | 0.791427 | 3 | 0 | 3 |
| SPEG | EBF2 | 0.773301 | 3 | 0 | 3 |
| SPEG | ZNF683 | 0.769504 | 3 | 0 | 3 |
For details and further investigation, click here
