| Full name: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 | Alias Symbol: cl-5|nkat4|nkat4a|nkat4b|CD158K | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 3812 | HGNC ID: HGNC:6339 | Ensembl Gene: ENSG00000240403 | OMIM ID: 604947 |
| Drug and gene relationship at DGIdb | |||
KIR3DL2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of KIR3DL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | KIR3DL2 | 3812 | 132162 | 0.0190 | 0.8422 | |
| GSE53624 | KIR3DL2 | 3812 | 132162 | -0.7774 | 0.0000 | |
| GSE97050 | KIR3DL2 | 3812 | A_33_P3233010 | 0.0110 | 0.9712 | |
| TCGA | KIR3DL2 | 3812 | RNAseq | 1.1129 | 0.2736 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KIR3DL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIR3DL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIR3DL2 | 3812 | 3 | 4 | 23 | |
| GSE20123 | KIR3DL2 | 3812 | 3 | 3 | 24 | |
| GSE43470 | KIR3DL2 | 3812 | 3 | 11 | 29 | |
| GSE46452 | KIR3DL2 | 3812 | 45 | 1 | 13 | |
| GSE47630 | KIR3DL2 | 3812 | 8 | 6 | 26 | |
| GSE54993 | KIR3DL2 | 3812 | 17 | 4 | 49 | |
| GSE54994 | KIR3DL2 | 3812 | 4 | 13 | 36 | |
| GSE60625 | KIR3DL2 | 3812 | 9 | 0 | 2 | |
| GSE74703 | KIR3DL2 | 3812 | 3 | 7 | 26 | |
| GSE74704 | KIR3DL2 | 3812 | 3 | 1 | 16 | |
| TCGA | KIR3DL2 | 3812 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of KIR3DL2:
Generating mutation plots.
Highly correlated genes for KIR3DL2:
Showing top 20/94 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIR3DL2 | KRTAP9-6 | 0.855002 | 3 | 0 | 3 |
| KIR3DL2 | CCIN | 0.837435 | 3 | 0 | 3 |
| KIR3DL2 | UTF1 | 0.819309 | 3 | 0 | 3 |
| KIR3DL2 | CALY | 0.816301 | 3 | 0 | 3 |
| KIR3DL2 | SLC36A4 | 0.805192 | 3 | 0 | 3 |
| KIR3DL2 | DEFB132 | 0.80013 | 3 | 0 | 3 |
| KIR3DL2 | VSIG8 | 0.79361 | 3 | 0 | 3 |
| KIR3DL2 | CTPS2 | 0.790867 | 3 | 0 | 3 |
| KIR3DL2 | ACRBP | 0.78934 | 3 | 0 | 3 |
| KIR3DL2 | SFTPA2 | 0.788654 | 3 | 0 | 3 |
| KIR3DL2 | TMEM150A | 0.788044 | 3 | 0 | 3 |
| KIR3DL2 | VAX2 | 0.786795 | 3 | 0 | 3 |
| KIR3DL2 | CDH24 | 0.782652 | 3 | 0 | 3 |
| KIR3DL2 | APOB | 0.78134 | 3 | 0 | 3 |
| KIR3DL2 | TP53AIP1 | 0.778678 | 3 | 0 | 3 |
| KIR3DL2 | KRTAP10-1 | 0.776307 | 3 | 0 | 3 |
| KIR3DL2 | WWOX | 0.773806 | 3 | 0 | 3 |
| KIR3DL2 | SPSB4 | 0.773663 | 3 | 0 | 3 |
| KIR3DL2 | CELA3A | 0.772752 | 3 | 0 | 3 |
| KIR3DL2 | ZC3H18 | 0.771175 | 3 | 0 | 3 |
For details and further investigation, click here
