| Full name: speedy/RINGO cell cycle regulator family member E1 | Alias Symbol: Ringo1|SPDYE | ||
| Type: protein-coding gene | Cytoband: 7p13 | ||
| Entrez ID: 285955 | HGNC ID: HGNC:16408 | Ensembl Gene: ENSG00000136206 | OMIM ID: 617623 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SPDYE1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of SPDYE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SPDYE1 | 285955 | 113686 | 0.5835 | 0.0000 | |
| GSE53624 | SPDYE1 | 285955 | 72103 | 0.2069 | 0.0851 | |
| GSE97050 | SPDYE1 | 285955 | A_23_P425967 | 0.3792 | 0.2154 | |
| SRP007169 | SPDYE1 | 285955 | RNAseq | 0.9131 | 0.3794 | |
| SRP133303 | SPDYE1 | 285955 | RNAseq | 0.3380 | 0.0398 | |
| SRP159526 | SPDYE1 | 285955 | RNAseq | 0.4651 | 0.1717 | |
| SRP193095 | SPDYE1 | 285955 | RNAseq | 0.6074 | 0.0242 | |
| SRP219564 | SPDYE1 | 285955 | RNAseq | 0.2201 | 0.6563 | |
| TCGA | SPDYE1 | 285955 | RNAseq | 0.0427 | 0.8039 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPDYE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPDYE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPDYE1 | 285955 | 14 | 0 | 16 | |
| GSE20123 | SPDYE1 | 285955 | 13 | 0 | 17 | |
| GSE43470 | SPDYE1 | 285955 | 4 | 0 | 39 | |
| GSE46452 | SPDYE1 | 285955 | 11 | 1 | 47 | |
| GSE47630 | SPDYE1 | 285955 | 8 | 1 | 31 | |
| GSE54993 | SPDYE1 | 285955 | 0 | 8 | 62 | |
| GSE54994 | SPDYE1 | 285955 | 18 | 4 | 31 | |
| GSE60625 | SPDYE1 | 285955 | 0 | 0 | 11 | |
| GSE74703 | SPDYE1 | 285955 | 4 | 0 | 32 | |
| GSE74704 | SPDYE1 | 285955 | 7 | 0 | 13 | |
| TCGA | SPDYE1 | 285955 | 51 | 6 | 39 |
Total number of gains: 130; Total number of losses: 20; Total Number of normals: 338.
Somatic mutations of SPDYE1:
Generating mutation plots.
Highly correlated genes for SPDYE1:
Showing top 20/40 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPDYE1 | SPDYE5 | 0.915123 | 3 | 0 | 3 |
| SPDYE1 | SPDYE3 | 0.8049 | 3 | 0 | 3 |
| SPDYE1 | TAS2R43 | 0.785227 | 3 | 0 | 3 |
| SPDYE1 | POM121 | 0.768002 | 3 | 0 | 3 |
| SPDYE1 | ZNF789 | 0.765693 | 3 | 0 | 3 |
| SPDYE1 | SRSF1 | 0.752565 | 3 | 0 | 3 |
| SPDYE1 | RNF165 | 0.751013 | 3 | 0 | 3 |
| SPDYE1 | MPV17L | 0.738084 | 3 | 0 | 3 |
| SPDYE1 | ZNF248 | 0.737906 | 3 | 0 | 3 |
| SPDYE1 | ZNF782 | 0.733907 | 3 | 0 | 3 |
| SPDYE1 | TAS2R19 | 0.730024 | 3 | 0 | 3 |
| SPDYE1 | CCDC84 | 0.727067 | 3 | 0 | 3 |
| SPDYE1 | ACAD11 | 0.720412 | 3 | 0 | 3 |
| SPDYE1 | TAS2R5 | 0.71973 | 3 | 0 | 3 |
| SPDYE1 | ANKRD36B | 0.719264 | 3 | 0 | 3 |
| SPDYE1 | LUC7L3 | 0.717208 | 3 | 0 | 3 |
| SPDYE1 | RBBP5 | 0.706337 | 3 | 0 | 3 |
| SPDYE1 | TAS2R50 | 0.706249 | 3 | 0 | 3 |
| SPDYE1 | SLC26A5 | 0.702471 | 3 | 0 | 3 |
| SPDYE1 | KRTAP12-2 | 0.701585 | 3 | 0 | 3 |
For details and further investigation, click here
