| Full name: speedy/RINGO cell cycle regulator family member E3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 441272 | HGNC ID: HGNC:35462 | Ensembl Gene: ENSG00000214300 | OMIM ID: 617625 |
| Drug and gene relationship at DGIdb | |||
SPDYE3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of SPDYE3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SPDYE3 | 441272 | 43635 | 0.5819 | 0.0000 | |
| GSE53624 | SPDYE3 | 441272 | 43635 | 0.5994 | 0.0000 | |
| GSE97050 | SPDYE3 | 441272 | A_32_P216734 | 0.0219 | 0.9200 | |
| SRP064894 | SPDYE3 | 441272 | RNAseq | 0.8195 | 0.0026 | |
| SRP133303 | SPDYE3 | 441272 | RNAseq | 0.3269 | 0.0591 | |
| SRP159526 | SPDYE3 | 441272 | RNAseq | 0.5331 | 0.1319 | |
| SRP219564 | SPDYE3 | 441272 | RNAseq | 0.7958 | 0.0463 | |
| TCGA | SPDYE3 | 441272 | RNAseq | 0.2876 | 0.0270 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPDYE3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPDYE3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPDYE3 | 441272 | 13 | 0 | 17 | |
| GSE20123 | SPDYE3 | 441272 | 13 | 0 | 17 | |
| GSE43470 | SPDYE3 | 441272 | 7 | 2 | 34 | |
| GSE46452 | SPDYE3 | 441272 | 11 | 1 | 47 | |
| GSE47630 | SPDYE3 | 441272 | 7 | 3 | 30 | |
| GSE54993 | SPDYE3 | 441272 | 1 | 9 | 60 | |
| GSE54994 | SPDYE3 | 441272 | 16 | 3 | 34 | |
| GSE60625 | SPDYE3 | 441272 | 0 | 0 | 11 | |
| GSE74703 | SPDYE3 | 441272 | 7 | 1 | 28 | |
| GSE74704 | SPDYE3 | 441272 | 9 | 0 | 11 | |
| TCGA | SPDYE3 | 441272 | 52 | 6 | 38 |
Total number of gains: 136; Total number of losses: 25; Total Number of normals: 327.
Somatic mutations of SPDYE3:
Generating mutation plots.
Highly correlated genes for SPDYE3:
Showing top 20/114 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPDYE3 | SPDYE1 | 0.8049 | 3 | 0 | 3 |
| SPDYE3 | ZNF789 | 0.764948 | 3 | 0 | 3 |
| SPDYE3 | PILRA | 0.742708 | 3 | 0 | 3 |
| SPDYE3 | ILF3 | 0.736701 | 3 | 0 | 3 |
| SPDYE3 | SPDYE5 | 0.733673 | 3 | 0 | 3 |
| SPDYE3 | POU2F1 | 0.733258 | 3 | 0 | 3 |
| SPDYE3 | PGAP1 | 0.727139 | 3 | 0 | 3 |
| SPDYE3 | TAS2R43 | 0.72628 | 3 | 0 | 3 |
| SPDYE3 | ESF1 | 0.718066 | 3 | 0 | 3 |
| SPDYE3 | SMAD2 | 0.715708 | 3 | 0 | 3 |
| SPDYE3 | TRRAP | 0.711308 | 3 | 0 | 3 |
| SPDYE3 | ACAD11 | 0.707807 | 3 | 0 | 3 |
| SPDYE3 | POM121 | 0.704768 | 3 | 0 | 3 |
| SPDYE3 | TYW1B | 0.704384 | 3 | 0 | 3 |
| SPDYE3 | KNTC1 | 0.701625 | 3 | 0 | 3 |
| SPDYE3 | CSPP1 | 0.698007 | 3 | 0 | 3 |
| SPDYE3 | USP42 | 0.696445 | 3 | 0 | 3 |
| SPDYE3 | SLC12A9 | 0.691874 | 3 | 0 | 3 |
| SPDYE3 | MAZ | 0.690417 | 3 | 0 | 3 |
| SPDYE3 | ZNF318 | 0.689814 | 3 | 0 | 3 |
For details and further investigation, click here
