| Full name: speedy/RINGO cell cycle regulator family member E5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 442590 | HGNC ID: HGNC:35464 | Ensembl Gene: ENSG00000170092 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
SPDYE5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of SPDYE5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SPDYE5 | 442590 | 8609 | 0.5633 | 0.0000 | |
| GSE53624 | SPDYE5 | 442590 | 8609 | 0.1617 | 0.2187 | |
| GSE97050 | SPDYE5 | 442590 | A_32_P177040 | 0.3311 | 0.2395 | |
| SRP007169 | SPDYE5 | 442590 | RNAseq | -0.5617 | 0.4595 | |
| SRP133303 | SPDYE5 | 442590 | RNAseq | 0.4800 | 0.0035 | |
| TCGA | SPDYE5 | 442590 | RNAseq | -0.0810 | 0.6535 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPDYE5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPDYE5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPDYE5 | 442590 | 14 | 1 | 15 | |
| GSE20123 | SPDYE5 | 442590 | 14 | 1 | 15 | |
| GSE43470 | SPDYE5 | 442590 | 3 | 2 | 38 | |
| GSE46452 | SPDYE5 | 442590 | 12 | 0 | 47 | |
| GSE47630 | SPDYE5 | 442590 | 7 | 2 | 31 | |
| GSE54993 | SPDYE5 | 442590 | 2 | 7 | 61 | |
| GSE54994 | SPDYE5 | 442590 | 14 | 3 | 36 | |
| GSE60625 | SPDYE5 | 442590 | 0 | 0 | 11 | |
| GSE74703 | SPDYE5 | 442590 | 3 | 1 | 32 | |
| GSE74704 | SPDYE5 | 442590 | 8 | 1 | 11 |
Total number of gains: 77; Total number of losses: 18; Total Number of normals: 297.
Somatic mutations of SPDYE5:
Generating mutation plots.
Highly correlated genes for SPDYE5:
Showing top 20/63 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPDYE5 | SPDYE1 | 0.915123 | 3 | 0 | 3 |
| SPDYE5 | TAS2R43 | 0.755812 | 3 | 0 | 3 |
| SPDYE5 | KLHL17 | 0.752901 | 3 | 0 | 3 |
| SPDYE5 | RNF165 | 0.737708 | 3 | 0 | 3 |
| SPDYE5 | SPDYE3 | 0.733673 | 3 | 0 | 3 |
| SPDYE5 | ZNF248 | 0.728668 | 3 | 0 | 3 |
| SPDYE5 | SRSF1 | 0.726612 | 3 | 0 | 3 |
| SPDYE5 | POM121 | 0.724012 | 3 | 0 | 3 |
| SPDYE5 | CCDC154 | 0.723232 | 3 | 0 | 3 |
| SPDYE5 | SLC26A5 | 0.719573 | 3 | 0 | 3 |
| SPDYE5 | COL11A2 | 0.704351 | 3 | 0 | 3 |
| SPDYE5 | KRTAP12-2 | 0.702462 | 3 | 0 | 3 |
| SPDYE5 | MPV17L | 0.702347 | 3 | 0 | 3 |
| SPDYE5 | ARL17A | 0.699512 | 3 | 0 | 3 |
| SPDYE5 | ANKRD36B | 0.69567 | 3 | 0 | 3 |
| SPDYE5 | ZNF789 | 0.694295 | 3 | 0 | 3 |
| SPDYE5 | SZT2 | 0.689843 | 3 | 0 | 3 |
| SPDYE5 | GPR153 | 0.687073 | 3 | 0 | 3 |
| SPDYE5 | TIGD1 | 0.684538 | 3 | 0 | 3 |
| SPDYE5 | RAVER1 | 0.680199 | 3 | 0 | 3 |
For details and further investigation, click here
