| Full name: serine and arginine rich splicing factor 1 | Alias Symbol: ASF|SF2|SRp30a|SF2p33|MGC5228 | ||
| Type: protein-coding gene | Cytoband: 17q22 | ||
| Entrez ID: 6426 | HGNC ID: HGNC:10780 | Ensembl Gene: ENSG00000136450 | OMIM ID: 600812 |
SRSF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection |
Expression of SRSF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRSF1 | 6426 | 211784_s_at | 0.1833 | 0.5379 | |
| GSE20347 | SRSF1 | 6426 | 211784_s_at | 0.3219 | 0.0013 | |
| GSE23400 | SRSF1 | 6426 | 201742_x_at | 0.5479 | 0.0000 | |
| GSE26886 | SRSF1 | 6426 | 211784_s_at | 0.3167 | 0.0542 | |
| GSE29001 | SRSF1 | 6426 | 211784_s_at | 0.3816 | 0.0160 | |
| GSE38129 | SRSF1 | 6426 | 211784_s_at | 0.3531 | 0.0006 | |
| GSE45670 | SRSF1 | 6426 | 211784_s_at | 0.2866 | 0.0034 | |
| GSE53622 | SRSF1 | 6426 | 64902 | 0.3773 | 0.0001 | |
| GSE53624 | SRSF1 | 6426 | 64902 | 0.2381 | 0.0443 | |
| GSE63941 | SRSF1 | 6426 | 211784_s_at | 0.5107 | 0.0426 | |
| GSE77861 | SRSF1 | 6426 | 211784_s_at | 0.2806 | 0.0575 | |
| GSE97050 | SRSF1 | 6426 | A_24_P921933 | 0.0632 | 0.8733 | |
| SRP007169 | SRSF1 | 6426 | RNAseq | 0.4780 | 0.1629 | |
| SRP008496 | SRSF1 | 6426 | RNAseq | 0.5541 | 0.0016 | |
| SRP064894 | SRSF1 | 6426 | RNAseq | 0.1565 | 0.2792 | |
| SRP133303 | SRSF1 | 6426 | RNAseq | 0.4674 | 0.0008 | |
| SRP159526 | SRSF1 | 6426 | RNAseq | 0.3074 | 0.1432 | |
| SRP193095 | SRSF1 | 6426 | RNAseq | 0.0975 | 0.1624 | |
| SRP219564 | SRSF1 | 6426 | RNAseq | 0.2596 | 0.4297 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRSF1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SRSF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRSF1 | 6426 | 5 | 1 | 24 | |
| GSE20123 | SRSF1 | 6426 | 5 | 1 | 24 | |
| GSE43470 | SRSF1 | 6426 | 3 | 0 | 40 | |
| GSE46452 | SRSF1 | 6426 | 32 | 0 | 27 | |
| GSE47630 | SRSF1 | 6426 | 7 | 1 | 32 | |
| GSE54993 | SRSF1 | 6426 | 2 | 5 | 63 | |
| GSE54994 | SRSF1 | 6426 | 8 | 6 | 39 | |
| GSE60625 | SRSF1 | 6426 | 4 | 0 | 7 | |
| GSE74703 | SRSF1 | 6426 | 3 | 0 | 33 | |
| GSE74704 | SRSF1 | 6426 | 4 | 1 | 15 | |
| TCGA | SRSF1 | 6426 | 26 | 8 | 62 |
Total number of gains: 99; Total number of losses: 23; Total Number of normals: 366.
Somatic mutations of SRSF1:
Generating mutation plots.
Highly correlated genes for SRSF1:
Showing top 20/1274 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRSF1 | TRIAP1 | 0.783693 | 3 | 0 | 3 |
| SRSF1 | ANAPC4 | 0.771246 | 3 | 0 | 3 |
| SRSF1 | EVL | 0.758161 | 3 | 0 | 3 |
| SRSF1 | PPHLN1 | 0.755473 | 3 | 0 | 3 |
| SRSF1 | SPDYE1 | 0.752565 | 3 | 0 | 3 |
| SRSF1 | LTV1 | 0.750917 | 5 | 0 | 4 |
| SRSF1 | ACAD11 | 0.744398 | 3 | 0 | 3 |
| SRSF1 | ZFHX3 | 0.728224 | 3 | 0 | 3 |
| SRSF1 | SPDYE5 | 0.726612 | 3 | 0 | 3 |
| SRSF1 | UHRF1BP1L | 0.722942 | 3 | 0 | 3 |
| SRSF1 | TAS2R43 | 0.717903 | 3 | 0 | 3 |
| SRSF1 | CWC27 | 0.712578 | 3 | 0 | 3 |
| SRSF1 | GOPC | 0.711684 | 4 | 0 | 4 |
| SRSF1 | CEBPZ | 0.707673 | 7 | 0 | 7 |
| SRSF1 | NNT | 0.705901 | 3 | 0 | 3 |
| SRSF1 | SLC25A29 | 0.702442 | 3 | 0 | 3 |
| SRSF1 | CEP97 | 0.701704 | 7 | 0 | 7 |
| SRSF1 | GZF1 | 0.701349 | 3 | 0 | 3 |
| SRSF1 | VMA21 | 0.700184 | 4 | 0 | 4 |
| SRSF1 | TOMM20 | 0.700169 | 5 | 0 | 4 |
For details and further investigation, click here
