| Full name: glutamate ionotropic receptor AMPA type subunit 4 | Alias Symbol: GluA4|GLURD | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 2893 | HGNC ID: HGNC:4574 | Ensembl Gene: ENSG00000152578 | OMIM ID: 138246 |
| Drug and gene relationship at DGIdb | |||
GRIA4 involved pathways:
Expression of GRIA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRIA4 | 2893 | 208464_at | -0.1181 | 0.5830 | |
| GSE20347 | GRIA4 | 2893 | 208464_at | -0.0241 | 0.7957 | |
| GSE23400 | GRIA4 | 2893 | 208464_at | -0.0365 | 0.1911 | |
| GSE26886 | GRIA4 | 2893 | 208464_at | -0.0538 | 0.6243 | |
| GSE29001 | GRIA4 | 2893 | 208464_at | -0.0684 | 0.6295 | |
| GSE38129 | GRIA4 | 2893 | 208464_at | -0.0884 | 0.2044 | |
| GSE45670 | GRIA4 | 2893 | 208464_at | -0.0618 | 0.5879 | |
| GSE53622 | GRIA4 | 2893 | 52237 | 0.3420 | 0.0061 | |
| GSE53624 | GRIA4 | 2893 | 52237 | 0.2123 | 0.0540 | |
| GSE63941 | GRIA4 | 2893 | 208464_at | -0.0373 | 0.8325 | |
| GSE77861 | GRIA4 | 2893 | 208464_at | -0.1159 | 0.2479 | |
| GSE97050 | GRIA4 | 2893 | A_33_P3217153 | -0.2208 | 0.2641 | |
| SRP133303 | GRIA4 | 2893 | RNAseq | 0.1089 | 0.5699 | |
| SRP219564 | GRIA4 | 2893 | RNAseq | 0.5917 | 0.1970 | |
| TCGA | GRIA4 | 2893 | RNAseq | -4.0406 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GRIA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRIA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRIA4 | 2893 | 0 | 13 | 17 | |
| GSE20123 | GRIA4 | 2893 | 0 | 13 | 17 | |
| GSE43470 | GRIA4 | 2893 | 2 | 6 | 35 | |
| GSE46452 | GRIA4 | 2893 | 3 | 26 | 30 | |
| GSE47630 | GRIA4 | 2893 | 2 | 19 | 19 | |
| GSE54993 | GRIA4 | 2893 | 10 | 0 | 60 | |
| GSE54994 | GRIA4 | 2893 | 4 | 19 | 30 | |
| GSE60625 | GRIA4 | 2893 | 0 | 3 | 8 | |
| GSE74703 | GRIA4 | 2893 | 1 | 4 | 31 | |
| GSE74704 | GRIA4 | 2893 | 0 | 9 | 11 | |
| TCGA | GRIA4 | 2893 | 8 | 46 | 42 |
Total number of gains: 30; Total number of losses: 158; Total Number of normals: 300.
Somatic mutations of GRIA4:
Generating mutation plots.
Highly correlated genes for GRIA4:
Showing top 20/449 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRIA4 | OR2T33 | 0.879569 | 3 | 0 | 3 |
| GRIA4 | ALG11 | 0.874603 | 3 | 0 | 3 |
| GRIA4 | SPEG | 0.848755 | 3 | 0 | 3 |
| GRIA4 | OR2AT4 | 0.846107 | 3 | 0 | 3 |
| GRIA4 | SLC26A5 | 0.840596 | 3 | 0 | 3 |
| GRIA4 | OR1L6 | 0.824883 | 3 | 0 | 3 |
| GRIA4 | KRTAP12-2 | 0.819136 | 3 | 0 | 3 |
| GRIA4 | NQO2 | 0.796136 | 3 | 0 | 3 |
| GRIA4 | ARL17A | 0.795276 | 3 | 0 | 3 |
| GRIA4 | USP17L2 | 0.778277 | 3 | 0 | 3 |
| GRIA4 | KRTAP10-9 | 0.774389 | 3 | 0 | 3 |
| GRIA4 | SZT2 | 0.771332 | 4 | 0 | 3 |
| GRIA4 | ASB3 | 0.761244 | 3 | 0 | 3 |
| GRIA4 | FAM205A | 0.758924 | 3 | 0 | 3 |
| GRIA4 | LINC00862 | 0.754519 | 3 | 0 | 3 |
| GRIA4 | OXTR | 0.753868 | 3 | 0 | 3 |
| GRIA4 | TAS2R43 | 0.750718 | 3 | 0 | 3 |
| GRIA4 | DNAJB7 | 0.750594 | 3 | 0 | 3 |
| GRIA4 | KIR3DL2 | 0.75019 | 3 | 0 | 3 |
| GRIA4 | LIPF | 0.749972 | 3 | 0 | 3 |
For details and further investigation, click here
