| Full name: ATP binding cassette subfamily C member 8 | Alias Symbol: HI|PHHI|SUR1|MRP8|ABC36|HHF1|TNDM2 | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 6833 | HGNC ID: HGNC:59 | Ensembl Gene: ENSG00000006071 | OMIM ID: 600509 |
| Related drugs: ACETOHEXAMIDE, CHLORPROPAMIDE, GLIMEPIRIDE, GLIPIZIDE, GLYBURIDE, MITIGLINIDE, NAMINIDIL, NATEGLINIDE, REPAGLINIDE, SARAKALIM... [more] | |||
ABCC8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04911 | Insulin secretion | |
| hsa04930 | Type II diabetes mellitus |
Expression of ABCC8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCC8 | 6833 | 210245_at | -0.2288 | 0.3533 | |
| GSE20347 | ABCC8 | 6833 | 210245_at | -0.1183 | 0.1447 | |
| GSE23400 | ABCC8 | 6833 | 210246_s_at | -0.1077 | 0.0039 | |
| GSE26886 | ABCC8 | 6833 | 210245_at | -0.1181 | 0.3369 | |
| GSE29001 | ABCC8 | 6833 | 210246_s_at | -0.0251 | 0.8773 | |
| GSE38129 | ABCC8 | 6833 | 210245_at | -0.2222 | 0.0068 | |
| GSE45670 | ABCC8 | 6833 | 210246_s_at | -0.1497 | 0.0953 | |
| GSE53622 | ABCC8 | 6833 | 128159 | 0.1815 | 0.0401 | |
| GSE53624 | ABCC8 | 6833 | 128159 | -0.0730 | 0.3804 | |
| GSE63941 | ABCC8 | 6833 | 210246_s_at | 0.5868 | 0.0157 | |
| GSE77861 | ABCC8 | 6833 | 210245_at | -0.2769 | 0.0151 | |
| GSE97050 | ABCC8 | 6833 | A_23_P24774 | -0.3079 | 0.3129 | |
| SRP133303 | ABCC8 | 6833 | RNAseq | -0.4302 | 0.0068 | |
| SRP193095 | ABCC8 | 6833 | RNAseq | -0.5050 | 0.0404 | |
| TCGA | ABCC8 | 6833 | RNAseq | -4.1840 | 0.0031 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ABCC8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCC8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCC8 | 6833 | 0 | 10 | 20 | |
| GSE20123 | ABCC8 | 6833 | 0 | 10 | 20 | |
| GSE43470 | ABCC8 | 6833 | 1 | 5 | 37 | |
| GSE46452 | ABCC8 | 6833 | 7 | 5 | 47 | |
| GSE47630 | ABCC8 | 6833 | 3 | 10 | 27 | |
| GSE54993 | ABCC8 | 6833 | 3 | 0 | 67 | |
| GSE54994 | ABCC8 | 6833 | 3 | 12 | 38 | |
| GSE60625 | ABCC8 | 6833 | 0 | 0 | 11 | |
| GSE74703 | ABCC8 | 6833 | 1 | 3 | 32 | |
| GSE74704 | ABCC8 | 6833 | 0 | 9 | 11 | |
| TCGA | ABCC8 | 6833 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 93; Total Number of normals: 366.
Somatic mutations of ABCC8:
Generating mutation plots.
Highly correlated genes for ABCC8:
Showing top 20/1063 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCC8 | TMEM229A | 0.785295 | 3 | 0 | 3 |
| ABCC8 | IQCD | 0.783982 | 3 | 0 | 3 |
| ABCC8 | YY2 | 0.768352 | 3 | 0 | 3 |
| ABCC8 | OR2T1 | 0.763405 | 3 | 0 | 3 |
| ABCC8 | PRSS38 | 0.763019 | 3 | 0 | 3 |
| ABCC8 | OR2B11 | 0.758994 | 3 | 0 | 3 |
| ABCC8 | ACSM2B | 0.75637 | 3 | 0 | 3 |
| ABCC8 | LELP1 | 0.756125 | 4 | 0 | 4 |
| ABCC8 | OR2D2 | 0.737032 | 3 | 0 | 3 |
| ABCC8 | OR2H2 | 0.72618 | 7 | 0 | 7 |
| ABCC8 | CELF5 | 0.725588 | 3 | 0 | 3 |
| ABCC8 | C20orf173 | 0.724113 | 5 | 0 | 4 |
| ABCC8 | BSX | 0.717498 | 3 | 0 | 3 |
| ABCC8 | C14orf180 | 0.716916 | 3 | 0 | 3 |
| ABCC8 | ABCC6 | 0.715486 | 4 | 0 | 4 |
| ABCC8 | OR2A5 | 0.715052 | 3 | 0 | 3 |
| ABCC8 | CDRT15 | 0.713236 | 3 | 0 | 3 |
| ABCC8 | OR2T27 | 0.712198 | 3 | 0 | 3 |
| ABCC8 | LYZL2 | 0.711226 | 3 | 0 | 3 |
| ABCC8 | RASL10B | 0.710523 | 5 | 0 | 5 |
For details and further investigation, click here
