| Full name: ATP binding cassette subfamily C member 6 | Alias Symbol: MRP6|EST349056|MLP1|URG7 | ||
| Type: protein-coding gene | Cytoband: 16p13.11 | ||
| Entrez ID: 368 | HGNC ID: HGNC:57 | Ensembl Gene: ENSG00000091262 | OMIM ID: 603234 |
| Drug and gene relationship at DGIdb | |||
Expression of ABCC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCC6 | 368 | 208480_s_at | 0.1402 | 0.5670 | |
| GSE20347 | ABCC6 | 368 | 208480_s_at | -0.0355 | 0.5771 | |
| GSE23400 | ABCC6 | 368 | 215559_at | -0.1024 | 0.0012 | |
| GSE26886 | ABCC6 | 368 | 208480_s_at | 0.2512 | 0.0552 | |
| GSE29001 | ABCC6 | 368 | 208480_s_at | -0.0832 | 0.4494 | |
| GSE38129 | ABCC6 | 368 | 208480_s_at | 0.0218 | 0.7193 | |
| GSE45670 | ABCC6 | 368 | 208480_s_at | 0.0266 | 0.8416 | |
| GSE53622 | ABCC6 | 368 | 99189 | 0.0046 | 0.9586 | |
| GSE53624 | ABCC6 | 368 | 99189 | -0.1077 | 0.2442 | |
| GSE63941 | ABCC6 | 368 | 208480_s_at | 0.0377 | 0.8112 | |
| GSE77861 | ABCC6 | 368 | 208480_s_at | -0.0682 | 0.6408 | |
| GSE97050 | ABCC6 | 368 | A_33_P3298043 | -0.0979 | 0.6083 | |
| SRP133303 | ABCC6 | 368 | RNAseq | -0.5332 | 0.1920 | |
| SRP159526 | ABCC6 | 368 | RNAseq | 0.9548 | 0.2310 | |
| SRP219564 | ABCC6 | 368 | RNAseq | -0.3634 | 0.6361 | |
| TCGA | ABCC6 | 368 | RNAseq | -1.8014 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ABCC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCC6 | 368 | 5 | 4 | 21 | |
| GSE20123 | ABCC6 | 368 | 5 | 3 | 22 | |
| GSE43470 | ABCC6 | 368 | 3 | 3 | 37 | |
| GSE46452 | ABCC6 | 368 | 38 | 1 | 20 | |
| GSE47630 | ABCC6 | 368 | 11 | 6 | 23 | |
| GSE54993 | ABCC6 | 368 | 3 | 5 | 62 | |
| GSE54994 | ABCC6 | 368 | 3 | 10 | 40 | |
| GSE60625 | ABCC6 | 368 | 4 | 0 | 7 | |
| GSE74703 | ABCC6 | 368 | 3 | 2 | 31 | |
| GSE74704 | ABCC6 | 368 | 2 | 1 | 17 | |
| TCGA | ABCC6 | 368 | 20 | 12 | 64 |
Total number of gains: 97; Total number of losses: 47; Total Number of normals: 344.
Somatic mutations of ABCC6:
Generating mutation plots.
Highly correlated genes for ABCC6:
Showing top 20/582 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCC6 | LRFN4 | 0.794799 | 3 | 0 | 3 |
| ABCC6 | DRD2 | 0.788193 | 3 | 0 | 3 |
| ABCC6 | SHANK1 | 0.776879 | 4 | 0 | 4 |
| ABCC6 | TRIM10 | 0.775183 | 3 | 0 | 3 |
| ABCC6 | CHRND | 0.771431 | 3 | 0 | 3 |
| ABCC6 | CNTD2 | 0.770184 | 3 | 0 | 3 |
| ABCC6 | LMAN1L | 0.764293 | 4 | 0 | 4 |
| ABCC6 | GALR3 | 0.755577 | 3 | 0 | 3 |
| ABCC6 | DRG2 | 0.752025 | 3 | 0 | 3 |
| ABCC6 | ACSM5 | 0.751538 | 3 | 0 | 3 |
| ABCC6 | PRPF19 | 0.74792 | 3 | 0 | 3 |
| ABCC6 | SIGLEC7 | 0.747329 | 3 | 0 | 3 |
| ABCC6 | MOS | 0.74559 | 3 | 0 | 3 |
| ABCC6 | MYBPH | 0.743999 | 4 | 0 | 4 |
| ABCC6 | DPYSL4 | 0.743975 | 4 | 0 | 4 |
| ABCC6 | CD247 | 0.742776 | 3 | 0 | 3 |
| ABCC6 | CYP2D6 | 0.738425 | 4 | 0 | 4 |
| ABCC6 | RASL10A | 0.7377 | 3 | 0 | 3 |
| ABCC6 | IFNA4 | 0.737057 | 3 | 0 | 3 |
| ABCC6 | RGR | 0.735848 | 4 | 0 | 4 |
For details and further investigation, click here
