| Full name: advanced glycosylation end-product specific receptor | Alias Symbol: RAGE|SCARJ1 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 177 | HGNC ID: HGNC:320 | Ensembl Gene: ENSG00000204305 | OMIM ID: 600214 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
AGER involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
Expression of AGER:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGER | 177 | 217046_s_at | -0.0192 | 0.9466 | |
| GSE20347 | AGER | 177 | 217046_s_at | -0.1797 | 0.0511 | |
| GSE23400 | AGER | 177 | 217046_s_at | -0.1580 | 0.0000 | |
| GSE26886 | AGER | 177 | 217046_s_at | 0.2095 | 0.0771 | |
| GSE29001 | AGER | 177 | 217046_s_at | -0.1030 | 0.4468 | |
| GSE38129 | AGER | 177 | 217046_s_at | -0.2266 | 0.0027 | |
| GSE45670 | AGER | 177 | 217046_s_at | -0.0202 | 0.8611 | |
| GSE53622 | AGER | 177 | 101433 | -0.1734 | 0.2731 | |
| GSE53624 | AGER | 177 | 133541 | -0.1831 | 0.0893 | |
| GSE63941 | AGER | 177 | 217046_s_at | 0.0739 | 0.6749 | |
| GSE77861 | AGER | 177 | 217046_s_at | -0.1932 | 0.1978 | |
| GSE97050 | AGER | 177 | A_33_P3396010 | -0.1146 | 0.6191 | |
| SRP064894 | AGER | 177 | RNAseq | 0.3987 | 0.0254 | |
| SRP133303 | AGER | 177 | RNAseq | -0.3954 | 0.1364 | |
| SRP159526 | AGER | 177 | RNAseq | 0.2178 | 0.7251 | |
| SRP193095 | AGER | 177 | RNAseq | 0.3103 | 0.0857 | |
| SRP219564 | AGER | 177 | RNAseq | 0.1357 | 0.7969 | |
| TCGA | AGER | 177 | RNAseq | -0.0316 | 0.8477 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AGER expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AGER:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGER | 177 | 5 | 1 | 24 | |
| GSE20123 | AGER | 177 | 5 | 1 | 24 | |
| GSE43470 | AGER | 177 | 5 | 1 | 37 | |
| GSE46452 | AGER | 177 | 1 | 10 | 48 | |
| GSE47630 | AGER | 177 | 7 | 4 | 29 | |
| GSE54993 | AGER | 177 | 2 | 1 | 67 | |
| GSE54994 | AGER | 177 | 11 | 4 | 38 | |
| GSE60625 | AGER | 177 | 0 | 1 | 10 | |
| GSE74703 | AGER | 177 | 5 | 0 | 31 | |
| GSE74704 | AGER | 177 | 2 | 0 | 18 | |
| TCGA | AGER | 177 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 39; Total Number of normals: 390.
Somatic mutations of AGER:
Generating mutation plots.
Highly correlated genes for AGER:
Showing top 20/543 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGER | RASL10B | 0.809264 | 3 | 0 | 3 |
| AGER | C7orf61 | 0.785726 | 3 | 0 | 3 |
| AGER | ARHGAP30 | 0.77074 | 4 | 0 | 4 |
| AGER | FAM171A2 | 0.750955 | 4 | 0 | 4 |
| AGER | DUSP15 | 0.747941 | 4 | 0 | 4 |
| AGER | JSRP1 | 0.746056 | 4 | 0 | 4 |
| AGER | TRPM3 | 0.740815 | 3 | 0 | 3 |
| AGER | NOXA1 | 0.739569 | 4 | 0 | 4 |
| AGER | DHH | 0.73936 | 3 | 0 | 3 |
| AGER | HBM | 0.72718 | 3 | 0 | 3 |
| AGER | KIF19 | 0.727097 | 3 | 0 | 3 |
| AGER | KLK14 | 0.72651 | 3 | 0 | 3 |
| AGER | USH1C | 0.719291 | 3 | 0 | 3 |
| AGER | TBX4 | 0.716293 | 5 | 0 | 4 |
| AGER | ROBO3 | 0.715977 | 3 | 0 | 3 |
| AGER | C11orf94 | 0.715682 | 3 | 0 | 3 |
| AGER | C9orf131 | 0.715258 | 4 | 0 | 3 |
| AGER | ARMC5 | 0.707476 | 4 | 0 | 3 |
| AGER | VWA5B2 | 0.707404 | 3 | 0 | 3 |
| AGER | POMT2 | 0.704979 | 3 | 0 | 3 |
For details and further investigation, click here
