| Full name: roundabout guidance receptor 3 | Alias Symbol: RBIG1|FLJ21044|HGPS | ||
| Type: protein-coding gene | Cytoband: 11q24.2 | ||
| Entrez ID: 64221 | HGNC ID: HGNC:13433 | Ensembl Gene: ENSG00000154134 | OMIM ID: 608630 |
| Drug and gene relationship at DGIdb | |||
ROBO3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of ROBO3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ROBO3 | 64221 | 219550_at | -0.3957 | 0.3485 | |
| GSE20347 | ROBO3 | 64221 | 219550_at | 0.0155 | 0.9459 | |
| GSE23400 | ROBO3 | 64221 | 219550_at | -0.1862 | 0.0001 | |
| GSE26886 | ROBO3 | 64221 | 219550_at | 0.7682 | 0.0038 | |
| GSE29001 | ROBO3 | 64221 | 219550_at | -0.1900 | 0.3781 | |
| GSE38129 | ROBO3 | 64221 | 219550_at | -0.2275 | 0.1942 | |
| GSE45670 | ROBO3 | 64221 | 219550_at | -0.3578 | 0.3345 | |
| GSE53622 | ROBO3 | 64221 | 16078 | 0.0017 | 0.9866 | |
| GSE53624 | ROBO3 | 64221 | 16078 | 0.0411 | 0.6227 | |
| GSE63941 | ROBO3 | 64221 | 219550_at | -0.1491 | 0.8083 | |
| GSE77861 | ROBO3 | 64221 | 219550_at | 0.0365 | 0.8396 | |
| GSE97050 | ROBO3 | 64221 | A_23_P87082 | -0.0759 | 0.8255 | |
| SRP064894 | ROBO3 | 64221 | RNAseq | -0.1902 | 0.5987 | |
| SRP133303 | ROBO3 | 64221 | RNAseq | -0.8996 | 0.0037 | |
| SRP159526 | ROBO3 | 64221 | RNAseq | -0.2272 | 0.6531 | |
| SRP219564 | ROBO3 | 64221 | RNAseq | -0.0824 | 0.8186 | |
| TCGA | ROBO3 | 64221 | RNAseq | 0.0433 | 0.8183 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ROBO3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ROBO3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ROBO3 | 64221 | 0 | 13 | 17 | |
| GSE20123 | ROBO3 | 64221 | 0 | 13 | 17 | |
| GSE43470 | ROBO3 | 64221 | 2 | 7 | 34 | |
| GSE46452 | ROBO3 | 64221 | 3 | 26 | 30 | |
| GSE47630 | ROBO3 | 64221 | 2 | 19 | 19 | |
| GSE54993 | ROBO3 | 64221 | 10 | 0 | 60 | |
| GSE54994 | ROBO3 | 64221 | 5 | 19 | 29 | |
| GSE60625 | ROBO3 | 64221 | 0 | 3 | 8 | |
| GSE74703 | ROBO3 | 64221 | 1 | 5 | 30 | |
| GSE74704 | ROBO3 | 64221 | 0 | 9 | 11 | |
| TCGA | ROBO3 | 64221 | 6 | 50 | 40 |
Total number of gains: 29; Total number of losses: 164; Total Number of normals: 295.
Somatic mutations of ROBO3:
Generating mutation plots.
Highly correlated genes for ROBO3:
Showing top 20/90 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ROBO3 | AGER | 0.715977 | 3 | 0 | 3 |
| ROBO3 | RAD52 | 0.689329 | 3 | 0 | 3 |
| ROBO3 | BMF | 0.679302 | 3 | 0 | 3 |
| ROBO3 | FRMD1 | 0.67811 | 3 | 0 | 3 |
| ROBO3 | HDC | 0.676472 | 3 | 0 | 3 |
| ROBO3 | SCAMP5 | 0.675717 | 3 | 0 | 3 |
| ROBO3 | DSCAM | 0.644818 | 3 | 0 | 3 |
| ROBO3 | SLC2A11 | 0.640707 | 3 | 0 | 3 |
| ROBO3 | LRCH4 | 0.640079 | 4 | 0 | 3 |
| ROBO3 | GALT | 0.638603 | 4 | 0 | 3 |
| ROBO3 | FUT7 | 0.632145 | 4 | 0 | 3 |
| ROBO3 | LHFPL4 | 0.631105 | 4 | 0 | 3 |
| ROBO3 | FAM171A2 | 0.630102 | 3 | 0 | 3 |
| ROBO3 | SHISA4 | 0.629772 | 4 | 0 | 3 |
| ROBO3 | CACNG4 | 0.628433 | 3 | 0 | 3 |
| ROBO3 | FBLN7 | 0.621091 | 4 | 0 | 3 |
| ROBO3 | MAN2C1 | 0.620457 | 3 | 0 | 3 |
| ROBO3 | ABCB9 | 0.619937 | 3 | 0 | 3 |
| ROBO3 | CDH4 | 0.615468 | 4 | 0 | 3 |
| ROBO3 | PHYHIP | 0.61416 | 4 | 0 | 3 |
For details and further investigation, click here
