| Full name: desert hedgehog signaling molecule | Alias Symbol: HHG-3|MGC35145 | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 50846 | HGNC ID: HGNC:2865 | Ensembl Gene: ENSG00000139549 | OMIM ID: 605423 |
| Drug and gene relationship at DGIdb | |||
DHH involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway |
Expression of DHH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHH | 50846 | 1552730_at | 0.0437 | 0.9027 | |
| GSE26886 | DHH | 50846 | 1552730_at | 0.0335 | 0.8039 | |
| GSE45670 | DHH | 50846 | 1552730_at | -0.1536 | 0.0882 | |
| GSE53622 | DHH | 50846 | 98154 | -0.4633 | 0.0000 | |
| GSE53624 | DHH | 50846 | 98154 | -0.2151 | 0.0112 | |
| GSE63941 | DHH | 50846 | 1552730_at | 0.1131 | 0.4157 | |
| GSE77861 | DHH | 50846 | 1552730_at | -0.1127 | 0.2038 | |
| GSE97050 | DHH | 50846 | A_33_P3338740 | 0.2301 | 0.4095 | |
| SRP133303 | DHH | 50846 | RNAseq | -0.7449 | 0.0014 | |
| TCGA | DHH | 50846 | RNAseq | -0.8311 | 0.1023 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DHH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHH | 50846 | 6 | 1 | 23 | |
| GSE20123 | DHH | 50846 | 6 | 1 | 23 | |
| GSE43470 | DHH | 50846 | 4 | 1 | 38 | |
| GSE46452 | DHH | 50846 | 8 | 1 | 50 | |
| GSE47630 | DHH | 50846 | 11 | 2 | 27 | |
| GSE54993 | DHH | 50846 | 0 | 5 | 65 | |
| GSE54994 | DHH | 50846 | 4 | 1 | 48 | |
| GSE60625 | DHH | 50846 | 0 | 0 | 11 | |
| GSE74703 | DHH | 50846 | 4 | 1 | 31 | |
| GSE74704 | DHH | 50846 | 4 | 1 | 15 | |
| TCGA | DHH | 50846 | 16 | 13 | 67 |
Total number of gains: 63; Total number of losses: 27; Total Number of normals: 398.
Somatic mutations of DHH:
Generating mutation plots.
Highly correlated genes for DHH:
Showing top 20/115 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHH | VWA5B2 | 0.759402 | 3 | 0 | 3 |
| DHH | FGF17 | 0.748747 | 3 | 0 | 3 |
| DHH | PRRG3 | 0.747523 | 3 | 0 | 3 |
| DHH | OR2H2 | 0.740039 | 3 | 0 | 3 |
| DHH | AGER | 0.73936 | 3 | 0 | 3 |
| DHH | DPEP3 | 0.731295 | 3 | 0 | 3 |
| DHH | KCNQ4 | 0.730278 | 3 | 0 | 3 |
| DHH | PSPN | 0.726825 | 3 | 0 | 3 |
| DHH | DPYSL4 | 0.726511 | 3 | 0 | 3 |
| DHH | ZFHX2 | 0.72321 | 3 | 0 | 3 |
| DHH | PRLH | 0.72035 | 3 | 0 | 3 |
| DHH | KLHL14 | 0.717043 | 3 | 0 | 3 |
| DHH | PTCRA | 0.701591 | 3 | 0 | 3 |
| DHH | TNXB | 0.698215 | 3 | 0 | 3 |
| DHH | CFP | 0.691847 | 3 | 0 | 3 |
| DHH | MYL4 | 0.691033 | 4 | 0 | 4 |
| DHH | MYH13 | 0.690193 | 4 | 0 | 3 |
| DHH | WFIKKN2 | 0.686282 | 3 | 0 | 3 |
| DHH | GP9 | 0.68598 | 3 | 0 | 3 |
| DHH | ENHO | 0.685435 | 3 | 0 | 3 |
For details and further investigation, click here
