| Full name: USH1 protein network component harmonin | Alias Symbol: PDZ73|harmonin|NY-CO-37|NY-CO-38|PDZ-73|AIE-75|PDZD7C | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 10083 | HGNC ID: HGNC:12597 | Ensembl Gene: ENSG00000006611 | OMIM ID: 605242 |
| Drug and gene relationship at DGIdb | |||
Expression of USH1C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USH1C | 10083 | 205137_x_at | -0.0818 | 0.7991 | |
| GSE20347 | USH1C | 10083 | 205137_x_at | -0.0133 | 0.9105 | |
| GSE23400 | USH1C | 10083 | 205137_x_at | -0.2289 | 0.0000 | |
| GSE26886 | USH1C | 10083 | 205137_x_at | 0.0645 | 0.6365 | |
| GSE29001 | USH1C | 10083 | 221173_at | -0.0358 | 0.9065 | |
| GSE38129 | USH1C | 10083 | 205137_x_at | -0.0831 | 0.4741 | |
| GSE45670 | USH1C | 10083 | 205137_x_at | 0.1080 | 0.2538 | |
| GSE53622 | USH1C | 10083 | 7422 | -0.0983 | 0.3163 | |
| GSE53624 | USH1C | 10083 | 7422 | 0.0925 | 0.2469 | |
| GSE63941 | USH1C | 10083 | 205137_x_at | 0.2267 | 0.4083 | |
| GSE77861 | USH1C | 10083 | 205137_x_at | -0.0710 | 0.7532 | |
| GSE97050 | USH1C | 10083 | A_23_P116430 | -0.0299 | 0.9154 | |
| TCGA | USH1C | 10083 | RNAseq | -2.9223 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by USH1C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USH1C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USH1C | 10083 | 0 | 10 | 20 | |
| GSE20123 | USH1C | 10083 | 0 | 10 | 20 | |
| GSE43470 | USH1C | 10083 | 1 | 5 | 37 | |
| GSE46452 | USH1C | 10083 | 7 | 5 | 47 | |
| GSE47630 | USH1C | 10083 | 3 | 10 | 27 | |
| GSE54993 | USH1C | 10083 | 3 | 0 | 67 | |
| GSE54994 | USH1C | 10083 | 3 | 12 | 38 | |
| GSE60625 | USH1C | 10083 | 0 | 0 | 11 | |
| GSE74703 | USH1C | 10083 | 1 | 3 | 32 | |
| GSE74704 | USH1C | 10083 | 0 | 9 | 11 | |
| TCGA | USH1C | 10083 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 93; Total Number of normals: 366.
Somatic mutations of USH1C:
Generating mutation plots.
Highly correlated genes for USH1C:
Showing top 20/1103 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USH1C | CLCNKA | 0.796004 | 3 | 0 | 3 |
| USH1C | DAB1 | 0.784492 | 5 | 0 | 5 |
| USH1C | ADORA3 | 0.778051 | 3 | 0 | 3 |
| USH1C | SHC2 | 0.777372 | 3 | 0 | 3 |
| USH1C | SPTA1 | 0.775299 | 3 | 0 | 3 |
| USH1C | TMEM229A | 0.757096 | 3 | 0 | 3 |
| USH1C | SPACA3 | 0.754715 | 3 | 0 | 3 |
| USH1C | SLC9A7 | 0.752746 | 3 | 0 | 3 |
| USH1C | TDGF1 | 0.750832 | 3 | 0 | 3 |
| USH1C | SEMA3B | 0.750818 | 3 | 0 | 3 |
| USH1C | CYP2D6 | 0.747405 | 6 | 0 | 6 |
| USH1C | BPIFB4 | 0.741199 | 3 | 0 | 3 |
| USH1C | C1QL2 | 0.738261 | 3 | 0 | 3 |
| USH1C | PABPN1L | 0.733666 | 3 | 0 | 3 |
| USH1C | KRTAP19-1 | 0.730745 | 4 | 0 | 4 |
| USH1C | BSX | 0.72766 | 3 | 0 | 3 |
| USH1C | TNNI2 | 0.722301 | 3 | 0 | 3 |
| USH1C | AGER | 0.719291 | 3 | 0 | 3 |
| USH1C | CIB3 | 0.719112 | 4 | 0 | 3 |
| USH1C | CRTAC1 | 0.716261 | 3 | 0 | 3 |
For details and further investigation, click here
