| Full name: T-box transcription factor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q23.2 | ||
| Entrez ID: 9496 | HGNC ID: HGNC:11603 | Ensembl Gene: ENSG00000121075 | OMIM ID: 601719 |
| Drug and gene relationship at DGIdb | |||
Expression of TBX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBX4 | 9496 | 220634_at | 0.0527 | 0.8473 | |
| GSE20347 | TBX4 | 9496 | 220634_at | -0.0362 | 0.6063 | |
| GSE23400 | TBX4 | 9496 | 220634_at | -0.0724 | 0.0103 | |
| GSE26886 | TBX4 | 9496 | 220634_at | -0.1987 | 0.0775 | |
| GSE29001 | TBX4 | 9496 | 220634_at | -0.0848 | 0.7072 | |
| GSE38129 | TBX4 | 9496 | 220634_at | -0.0876 | 0.2946 | |
| GSE45670 | TBX4 | 9496 | 220634_at | -0.0230 | 0.8470 | |
| GSE53622 | TBX4 | 9496 | 104489 | 0.6286 | 0.0000 | |
| GSE53624 | TBX4 | 9496 | 104489 | 0.7226 | 0.0000 | |
| GSE63941 | TBX4 | 9496 | 220634_at | 0.1082 | 0.5609 | |
| GSE77861 | TBX4 | 9496 | 220634_at | -0.2353 | 0.1820 | |
| GSE97050 | TBX4 | 9496 | A_23_P4443 | 0.0889 | 0.6398 | |
| SRP133303 | TBX4 | 9496 | RNAseq | 1.6210 | 0.0004 | |
| TCGA | TBX4 | 9496 | RNAseq | 2.9196 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TBX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBX4 | 9496 | 4 | 1 | 25 | |
| GSE20123 | TBX4 | 9496 | 4 | 1 | 25 | |
| GSE43470 | TBX4 | 9496 | 5 | 0 | 38 | |
| GSE46452 | TBX4 | 9496 | 32 | 0 | 27 | |
| GSE47630 | TBX4 | 9496 | 7 | 1 | 32 | |
| GSE54993 | TBX4 | 9496 | 2 | 5 | 63 | |
| GSE54994 | TBX4 | 9496 | 9 | 5 | 39 | |
| GSE60625 | TBX4 | 9496 | 4 | 0 | 7 | |
| GSE74703 | TBX4 | 9496 | 5 | 0 | 31 | |
| GSE74704 | TBX4 | 9496 | 3 | 1 | 16 | |
| TCGA | TBX4 | 9496 | 31 | 6 | 59 |
Total number of gains: 106; Total number of losses: 20; Total Number of normals: 362.
Somatic mutations of TBX4:
Generating mutation plots.
Highly correlated genes for TBX4:
Showing top 20/574 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBX4 | B3GALT1 | 0.835707 | 3 | 0 | 3 |
| TBX4 | CDH4 | 0.805141 | 3 | 0 | 3 |
| TBX4 | GCM2 | 0.801947 | 3 | 0 | 3 |
| TBX4 | DPPA4 | 0.762059 | 3 | 0 | 3 |
| TBX4 | FCN2 | 0.738412 | 5 | 0 | 4 |
| TBX4 | TERT | 0.736434 | 5 | 0 | 4 |
| TBX4 | AGRP | 0.735141 | 4 | 0 | 4 |
| TBX4 | RASL10B | 0.734938 | 3 | 0 | 3 |
| TBX4 | SLC24A4 | 0.72804 | 3 | 0 | 3 |
| TBX4 | MAG | 0.723728 | 5 | 0 | 4 |
| TBX4 | AGER | 0.716293 | 5 | 0 | 4 |
| TBX4 | OR10C1 | 0.711637 | 4 | 0 | 3 |
| TBX4 | ADAM21 | 0.706306 | 4 | 0 | 3 |
| TBX4 | C19orf81 | 0.705755 | 3 | 0 | 3 |
| TBX4 | FMR1NB | 0.703487 | 3 | 0 | 3 |
| TBX4 | MYOD1 | 0.702548 | 4 | 0 | 3 |
| TBX4 | TMEM212 | 0.702098 | 3 | 0 | 3 |
| TBX4 | TSPAN32 | 0.700856 | 5 | 0 | 4 |
| TBX4 | PCBP4 | 0.699063 | 3 | 0 | 3 |
| TBX4 | AFP | 0.69453 | 3 | 0 | 3 |
For details and further investigation, click here
