| Full name: aminolevulinate dehydratase | Alias Symbol: ALADH|PBGS | ||
| Type: protein-coding gene | Cytoband: 9q32 | ||
| Entrez ID: 210 | HGNC ID: HGNC:395 | Ensembl Gene: ENSG00000148218 | OMIM ID: 125270 |
| Drug and gene relationship at DGIdb | |||
Expression of ALAD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALAD | 210 | 218487_at | -0.9625 | 0.0250 | |
| GSE20347 | ALAD | 210 | 218487_at | -1.3226 | 0.0000 | |
| GSE23400 | ALAD | 210 | 218487_at | -0.2568 | 0.0000 | |
| GSE26886 | ALAD | 210 | 218487_at | -1.4244 | 0.0000 | |
| GSE29001 | ALAD | 210 | 218487_at | -0.8350 | 0.0005 | |
| GSE38129 | ALAD | 210 | 218487_at | -1.1857 | 0.0000 | |
| GSE45670 | ALAD | 210 | 218487_at | -0.6099 | 0.0028 | |
| GSE53622 | ALAD | 210 | 55355 | -0.9912 | 0.0000 | |
| GSE53624 | ALAD | 210 | 55355 | -1.1083 | 0.0000 | |
| GSE63941 | ALAD | 210 | 218487_at | -1.0532 | 0.0826 | |
| GSE77861 | ALAD | 210 | 218487_at | -0.8053 | 0.0008 | |
| GSE97050 | ALAD | 210 | A_23_P217114 | -0.4861 | 0.1836 | |
| SRP007169 | ALAD | 210 | RNAseq | -1.0583 | 0.0073 | |
| SRP008496 | ALAD | 210 | RNAseq | -0.9420 | 0.0009 | |
| SRP064894 | ALAD | 210 | RNAseq | -0.9253 | 0.0000 | |
| SRP133303 | ALAD | 210 | RNAseq | -1.0447 | 0.0000 | |
| SRP159526 | ALAD | 210 | RNAseq | -1.0178 | 0.0003 | |
| SRP193095 | ALAD | 210 | RNAseq | -0.9855 | 0.0000 | |
| SRP219564 | ALAD | 210 | RNAseq | -1.0888 | 0.0006 | |
| TCGA | ALAD | 210 | RNAseq | -0.5030 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by ALAD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALAD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALAD | 210 | 4 | 10 | 16 | |
| GSE20123 | ALAD | 210 | 4 | 10 | 16 | |
| GSE43470 | ALAD | 210 | 4 | 3 | 36 | |
| GSE46452 | ALAD | 210 | 6 | 13 | 40 | |
| GSE47630 | ALAD | 210 | 3 | 16 | 21 | |
| GSE54993 | ALAD | 210 | 3 | 3 | 64 | |
| GSE54994 | ALAD | 210 | 9 | 10 | 34 | |
| GSE60625 | ALAD | 210 | 0 | 0 | 11 | |
| GSE74703 | ALAD | 210 | 4 | 3 | 29 | |
| GSE74704 | ALAD | 210 | 2 | 8 | 10 | |
| TCGA | ALAD | 210 | 26 | 22 | 48 |
Total number of gains: 65; Total number of losses: 98; Total Number of normals: 325.
Somatic mutations of ALAD:
Generating mutation plots.
Highly correlated genes for ALAD:
Showing top 20/1477 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALAD | UBL3 | 0.77417 | 11 | 0 | 11 |
| ALAD | SH3BGRL2 | 0.77153 | 7 | 0 | 7 |
| ALAD | SNORA68 | 0.769735 | 4 | 0 | 4 |
| ALAD | GALNT12 | 0.766599 | 11 | 0 | 11 |
| ALAD | KIAA1211L | 0.761352 | 6 | 0 | 6 |
| ALAD | FLG-AS1 | 0.757515 | 6 | 0 | 6 |
| ALAD | TMEM61 | 0.75501 | 4 | 0 | 4 |
| ALAD | CAPN14 | 0.754092 | 6 | 0 | 6 |
| ALAD | ACPP | 0.753229 | 10 | 0 | 10 |
| ALAD | GPD1L | 0.752939 | 11 | 0 | 11 |
| ALAD | LNX1 | 0.752526 | 7 | 0 | 7 |
| ALAD | SAMD5 | 0.745668 | 7 | 0 | 7 |
| ALAD | ZNF823 | 0.742137 | 7 | 0 | 7 |
| ALAD | SLC10A5 | 0.740314 | 3 | 0 | 3 |
| ALAD | PLEKHA7 | 0.738761 | 6 | 0 | 6 |
| ALAD | CYSRT1 | 0.738642 | 6 | 0 | 6 |
| ALAD | VSIG10L | 0.737919 | 6 | 0 | 6 |
| ALAD | KAT2B | 0.73661 | 12 | 0 | 10 |
| ALAD | DYNLT3 | 0.732274 | 11 | 0 | 10 |
| ALAD | SFTA2 | 0.731797 | 4 | 0 | 4 |
For details and further investigation, click here
