| Full name: acid phosphatase, prostate | Alias Symbol: ACP3|ACP-3|PAP | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 55 | HGNC ID: HGNC:125 | Ensembl Gene: ENSG00000014257 | OMIM ID: 171790 |
| Drug and gene relationship at DGIdb | |||
Expression of ACPP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACPP | 55 | 204393_s_at | -3.3857 | 0.0319 | |
| GSE20347 | ACPP | 55 | 204393_s_at | -3.3993 | 0.0000 | |
| GSE23400 | ACPP | 55 | 204393_s_at | -1.5749 | 0.0000 | |
| GSE26886 | ACPP | 55 | 204393_s_at | -4.4829 | 0.0000 | |
| GSE29001 | ACPP | 55 | 204393_s_at | -2.7152 | 0.0001 | |
| GSE38129 | ACPP | 55 | 204393_s_at | -2.4442 | 0.0000 | |
| GSE45670 | ACPP | 55 | 204393_s_at | -1.6486 | 0.0078 | |
| GSE53622 | ACPP | 55 | 86537 | -2.7864 | 0.0000 | |
| GSE53624 | ACPP | 55 | 86537 | -3.4919 | 0.0000 | |
| GSE63941 | ACPP | 55 | 204393_s_at | 0.3565 | 0.6801 | |
| GSE77861 | ACPP | 55 | 204393_s_at | -2.6460 | 0.0003 | |
| GSE97050 | ACPP | 55 | A_24_P37589 | -0.6612 | 0.4213 | |
| TCGA | ACPP | 55 | RNAseq | 0.2500 | 0.2726 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by ACPP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACPP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACPP | 55 | 16 | 0 | 14 | |
| GSE20123 | ACPP | 55 | 16 | 0 | 14 | |
| GSE43470 | ACPP | 55 | 21 | 0 | 22 | |
| GSE46452 | ACPP | 55 | 15 | 4 | 40 | |
| GSE47630 | ACPP | 55 | 18 | 3 | 19 | |
| GSE54993 | ACPP | 55 | 2 | 8 | 60 | |
| GSE54994 | ACPP | 55 | 32 | 3 | 18 | |
| GSE60625 | ACPP | 55 | 0 | 6 | 5 | |
| GSE74703 | ACPP | 55 | 18 | 0 | 18 | |
| GSE74704 | ACPP | 55 | 11 | 0 | 9 | |
| TCGA | ACPP | 55 | 59 | 5 | 32 |
Total number of gains: 208; Total number of losses: 29; Total Number of normals: 251.
Somatic mutations of ACPP:
Generating mutation plots.
Highly correlated genes for ACPP:
Showing top 20/1883 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACPP | SLC16A6 | 0.891046 | 10 | 0 | 10 |
| ACPP | CYSRT1 | 0.882615 | 6 | 0 | 6 |
| ACPP | C5orf66-AS1 | 0.87165 | 6 | 0 | 6 |
| ACPP | FAM3D | 0.867314 | 8 | 0 | 8 |
| ACPP | CXCR2 | 0.866684 | 10 | 0 | 10 |
| ACPP | CRISP3 | 0.866168 | 11 | 0 | 11 |
| ACPP | ECM1 | 0.864629 | 11 | 0 | 11 |
| ACPP | GDPD3 | 0.863895 | 12 | 0 | 12 |
| ACPP | TMPRSS11E | 0.857144 | 11 | 0 | 11 |
| ACPP | KLB | 0.852587 | 6 | 0 | 6 |
| ACPP | VSIG10L | 0.851286 | 7 | 0 | 7 |
| ACPP | GYS2 | 0.850863 | 10 | 0 | 10 |
| ACPP | SMAGP | 0.850358 | 12 | 0 | 12 |
| ACPP | FCHO2 | 0.848723 | 6 | 0 | 6 |
| ACPP | SPINK5 | 0.848553 | 12 | 0 | 11 |
| ACPP | RAET1E | 0.84813 | 7 | 0 | 7 |
| ACPP | KAT2B | 0.847661 | 10 | 0 | 10 |
| ACPP | FUT3 | 0.847566 | 12 | 0 | 12 |
| ACPP | TMPRSS11B | 0.847017 | 8 | 0 | 8 |
| ACPP | MGST2 | 0.847016 | 10 | 0 | 10 |
For details and further investigation, click here
