| Full name: SH3 domain binding glutamate rich protein like 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q14.1 | ||
| Entrez ID: 83699 | HGNC ID: HGNC:15567 | Ensembl Gene: ENSG00000198478 | OMIM ID: 615678 |
| Drug and gene relationship at DGIdb | |||
Expression of SH3BGRL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3BGRL2 | 83699 | 225354_s_at | -2.5655 | 0.0086 | |
| GSE26886 | SH3BGRL2 | 83699 | 225354_s_at | -4.2717 | 0.0000 | |
| GSE45670 | SH3BGRL2 | 83699 | 225354_s_at | -2.6143 | 0.0001 | |
| GSE53622 | SH3BGRL2 | 83699 | 39246 | -4.1203 | 0.0000 | |
| GSE53624 | SH3BGRL2 | 83699 | 39246 | -4.5142 | 0.0000 | |
| GSE63941 | SH3BGRL2 | 83699 | 225354_s_at | -0.0226 | 0.9840 | |
| GSE77861 | SH3BGRL2 | 83699 | 225354_s_at | -2.1004 | 0.0005 | |
| GSE97050 | SH3BGRL2 | 83699 | A_33_P3343316 | -1.4694 | 0.1399 | |
| SRP007169 | SH3BGRL2 | 83699 | RNAseq | -5.3822 | 0.0000 | |
| SRP008496 | SH3BGRL2 | 83699 | RNAseq | -5.0110 | 0.0000 | |
| SRP064894 | SH3BGRL2 | 83699 | RNAseq | -3.8628 | 0.0000 | |
| SRP133303 | SH3BGRL2 | 83699 | RNAseq | -3.9301 | 0.0000 | |
| SRP159526 | SH3BGRL2 | 83699 | RNAseq | -4.2176 | 0.0000 | |
| SRP193095 | SH3BGRL2 | 83699 | RNAseq | -3.5735 | 0.0000 | |
| SRP219564 | SH3BGRL2 | 83699 | RNAseq | -3.7582 | 0.0000 | |
| TCGA | SH3BGRL2 | 83699 | RNAseq | -1.0881 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by SH3BGRL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH3BGRL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3BGRL2 | 83699 | 1 | 4 | 25 | |
| GSE20123 | SH3BGRL2 | 83699 | 1 | 3 | 26 | |
| GSE43470 | SH3BGRL2 | 83699 | 2 | 1 | 40 | |
| GSE46452 | SH3BGRL2 | 83699 | 3 | 11 | 45 | |
| GSE47630 | SH3BGRL2 | 83699 | 8 | 6 | 26 | |
| GSE54993 | SH3BGRL2 | 83699 | 3 | 2 | 65 | |
| GSE54994 | SH3BGRL2 | 83699 | 8 | 7 | 38 | |
| GSE60625 | SH3BGRL2 | 83699 | 0 | 1 | 10 | |
| GSE74703 | SH3BGRL2 | 83699 | 2 | 1 | 33 | |
| GSE74704 | SH3BGRL2 | 83699 | 0 | 2 | 18 | |
| TCGA | SH3BGRL2 | 83699 | 6 | 21 | 69 |
Total number of gains: 34; Total number of losses: 59; Total Number of normals: 395.
Somatic mutations of SH3BGRL2:
Generating mutation plots.
Highly correlated genes for SH3BGRL2:
Showing top 20/1867 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3BGRL2 | SIM2 | 0.898394 | 7 | 0 | 7 |
| SH3BGRL2 | CAB39L | 0.888238 | 7 | 0 | 7 |
| SH3BGRL2 | MGLL | 0.884257 | 7 | 0 | 7 |
| SH3BGRL2 | KAT2B | 0.882971 | 7 | 0 | 7 |
| SH3BGRL2 | GYS2 | 0.877315 | 6 | 0 | 6 |
| SH3BGRL2 | SAMD5 | 0.873352 | 7 | 0 | 7 |
| SH3BGRL2 | ABLIM3 | 0.871691 | 6 | 0 | 6 |
| SH3BGRL2 | C5orf66-AS1 | 0.868599 | 6 | 0 | 6 |
| SH3BGRL2 | PTN | 0.86436 | 5 | 0 | 5 |
| SH3BGRL2 | SMIM5 | 0.863409 | 6 | 0 | 6 |
| SH3BGRL2 | ABLIM1 | 0.863061 | 7 | 0 | 7 |
| SH3BGRL2 | HCG22 | 0.858815 | 6 | 0 | 6 |
| SH3BGRL2 | ENDOU | 0.857258 | 7 | 0 | 7 |
| SH3BGRL2 | C18orf25 | 0.85649 | 7 | 0 | 7 |
| SH3BGRL2 | CTTNBP2 | 0.852135 | 7 | 0 | 7 |
| SH3BGRL2 | GAB2 | 0.851552 | 6 | 0 | 6 |
| SH3BGRL2 | MAPK3 | 0.851351 | 7 | 0 | 7 |
| SH3BGRL2 | SLC10A5 | 0.851284 | 3 | 0 | 3 |
| SH3BGRL2 | LMBRD1 | 0.849077 | 7 | 0 | 7 |
| SH3BGRL2 | KALRN | 0.847357 | 6 | 0 | 6 |
For details and further investigation, click here
