| Full name: lysine acetyltransferase 2B | Alias Symbol: P/CAF|GCN5|GCN5L | ||
| Type: protein-coding gene | Cytoband: 3p24.3 | ||
| Entrez ID: 8850 | HGNC ID: HGNC:8638 | Ensembl Gene: ENSG00000114166 | OMIM ID: 602303 |
| Drug and gene relationship at DGIdb | |||
KAT2B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of KAT2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KAT2B | 8850 | 203845_at | -2.0752 | 0.0058 | |
| GSE20347 | KAT2B | 8850 | 203845_at | -3.0979 | 0.0000 | |
| GSE23400 | KAT2B | 8850 | 203845_at | -2.1107 | 0.0000 | |
| GSE26886 | KAT2B | 8850 | 203845_at | -3.3845 | 0.0000 | |
| GSE29001 | KAT2B | 8850 | 203845_at | -2.5671 | 0.0000 | |
| GSE38129 | KAT2B | 8850 | 203845_at | -2.8244 | 0.0000 | |
| GSE45670 | KAT2B | 8850 | 203845_at | -1.3600 | 0.0011 | |
| GSE53622 | KAT2B | 8850 | 55094 | -2.4553 | 0.0000 | |
| GSE53624 | KAT2B | 8850 | 55094 | -2.7881 | 0.0000 | |
| GSE63941 | KAT2B | 8850 | 203845_at | -2.0170 | 0.0131 | |
| GSE77861 | KAT2B | 8850 | 203845_at | -2.7982 | 0.0005 | |
| GSE97050 | KAT2B | 8850 | A_32_P159651 | -0.7672 | 0.1324 | |
| SRP007169 | KAT2B | 8850 | RNAseq | -4.5338 | 0.0000 | |
| SRP008496 | KAT2B | 8850 | RNAseq | -4.0865 | 0.0000 | |
| SRP064894 | KAT2B | 8850 | RNAseq | -2.5814 | 0.0000 | |
| SRP133303 | KAT2B | 8850 | RNAseq | -1.9030 | 0.0000 | |
| SRP159526 | KAT2B | 8850 | RNAseq | -2.3613 | 0.0000 | |
| SRP193095 | KAT2B | 8850 | RNAseq | -2.5242 | 0.0000 | |
| SRP219564 | KAT2B | 8850 | RNAseq | -2.0863 | 0.0001 | |
| TCGA | KAT2B | 8850 | RNAseq | -0.6197 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 18.
Survival by KAT2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KAT2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KAT2B | 8850 | 0 | 19 | 11 | |
| GSE20123 | KAT2B | 8850 | 0 | 19 | 11 | |
| GSE43470 | KAT2B | 8850 | 0 | 20 | 23 | |
| GSE46452 | KAT2B | 8850 | 2 | 17 | 40 | |
| GSE47630 | KAT2B | 8850 | 1 | 24 | 15 | |
| GSE54993 | KAT2B | 8850 | 6 | 1 | 63 | |
| GSE54994 | KAT2B | 8850 | 1 | 32 | 20 | |
| GSE60625 | KAT2B | 8850 | 5 | 0 | 6 | |
| GSE74703 | KAT2B | 8850 | 0 | 17 | 19 | |
| GSE74704 | KAT2B | 8850 | 0 | 13 | 7 | |
| TCGA | KAT2B | 8850 | 0 | 69 | 27 |
Total number of gains: 15; Total number of losses: 231; Total Number of normals: 242.
Somatic mutations of KAT2B:
Generating mutation plots.
Highly correlated genes for KAT2B:
Showing top 20/1898 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KAT2B | SNORA68 | 0.890717 | 4 | 0 | 4 |
| KAT2B | GBP6 | 0.886422 | 4 | 0 | 4 |
| KAT2B | SH3BGRL2 | 0.882971 | 7 | 0 | 7 |
| KAT2B | GPD1L | 0.864077 | 11 | 0 | 11 |
| KAT2B | SFTA2 | 0.862983 | 4 | 0 | 4 |
| KAT2B | CXCR2 | 0.856649 | 11 | 0 | 11 |
| KAT2B | GYS2 | 0.855559 | 10 | 0 | 10 |
| KAT2B | CRISP3 | 0.855513 | 11 | 0 | 10 |
| KAT2B | RMND5B | 0.850808 | 11 | 0 | 11 |
| KAT2B | SMIM5 | 0.84832 | 6 | 0 | 6 |
| KAT2B | ACPP | 0.847661 | 10 | 0 | 10 |
| KAT2B | RRAGD | 0.842731 | 11 | 0 | 11 |
| KAT2B | VSIG10L | 0.841665 | 6 | 0 | 6 |
| KAT2B | GDPD3 | 0.841537 | 10 | 0 | 10 |
| KAT2B | CAB39L | 0.839846 | 11 | 0 | 11 |
| KAT2B | CYSRT1 | 0.839675 | 6 | 0 | 6 |
| KAT2B | UBL3 | 0.837622 | 12 | 0 | 10 |
| KAT2B | RAB11A | 0.833481 | 11 | 0 | 11 |
| KAT2B | FAM214A | 0.831567 | 7 | 0 | 6 |
| KAT2B | CPPED1 | 0.831252 | 11 | 0 | 11 |
For details and further investigation, click here
