| Full name: ligand of numb-protein X 1 | Alias Symbol: MPDZ|PDZRN2 | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 84708 | HGNC ID: HGNC:6657 | Ensembl Gene: ENSG00000072201 | OMIM ID: 609732 |
| Drug and gene relationship at DGIdb | |||
Expression of LNX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LNX1 | 84708 | 223611_s_at | -1.8281 | 0.0475 | |
| GSE26886 | LNX1 | 84708 | 223611_s_at | -3.8526 | 0.0000 | |
| GSE45670 | LNX1 | 84708 | 223611_s_at | -1.2511 | 0.0446 | |
| GSE53622 | LNX1 | 84708 | 58748 | -2.1926 | 0.0000 | |
| GSE53624 | LNX1 | 84708 | 58748 | -2.9635 | 0.0000 | |
| GSE63941 | LNX1 | 84708 | 223611_s_at | 1.3247 | 0.2539 | |
| GSE77861 | LNX1 | 84708 | 223611_s_at | -2.9611 | 0.0031 | |
| GSE97050 | LNX1 | 84708 | A_23_P213137 | -0.7146 | 0.1452 | |
| SRP007169 | LNX1 | 84708 | RNAseq | -4.4988 | 0.0000 | |
| SRP008496 | LNX1 | 84708 | RNAseq | -4.0696 | 0.0000 | |
| SRP064894 | LNX1 | 84708 | RNAseq | -3.1242 | 0.0000 | |
| SRP133303 | LNX1 | 84708 | RNAseq | -2.3736 | 0.0000 | |
| SRP159526 | LNX1 | 84708 | RNAseq | -2.2583 | 0.0000 | |
| SRP193095 | LNX1 | 84708 | RNAseq | -2.7843 | 0.0000 | |
| SRP219564 | LNX1 | 84708 | RNAseq | -3.5801 | 0.0000 | |
| TCGA | LNX1 | 84708 | RNAseq | -0.3700 | 0.0144 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by LNX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LNX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LNX1 | 84708 | 3 | 11 | 16 | |
| GSE20123 | LNX1 | 84708 | 2 | 11 | 17 | |
| GSE43470 | LNX1 | 84708 | 0 | 14 | 29 | |
| GSE46452 | LNX1 | 84708 | 1 | 36 | 22 | |
| GSE47630 | LNX1 | 84708 | 1 | 18 | 21 | |
| GSE54993 | LNX1 | 84708 | 7 | 0 | 63 | |
| GSE54994 | LNX1 | 84708 | 2 | 10 | 41 | |
| GSE60625 | LNX1 | 84708 | 0 | 0 | 11 | |
| GSE74703 | LNX1 | 84708 | 0 | 12 | 24 | |
| GSE74704 | LNX1 | 84708 | 1 | 6 | 13 | |
| TCGA | LNX1 | 84708 | 20 | 26 | 50 |
Total number of gains: 37; Total number of losses: 144; Total Number of normals: 307.
Somatic mutations of LNX1:
Generating mutation plots.
Highly correlated genes for LNX1:
Showing top 20/1607 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LNX1 | SLC10A5 | 0.86432 | 3 | 0 | 3 |
| LNX1 | SH3BGRL2 | 0.841469 | 7 | 0 | 7 |
| LNX1 | FAM214A | 0.826216 | 6 | 0 | 6 |
| LNX1 | KAT2B | 0.822129 | 7 | 0 | 7 |
| LNX1 | CPEB3 | 0.817967 | 6 | 0 | 6 |
| LNX1 | C18orf25 | 0.815207 | 7 | 0 | 7 |
| LNX1 | ANXA9 | 0.814479 | 7 | 0 | 7 |
| LNX1 | FAM3B | 0.813577 | 6 | 0 | 6 |
| LNX1 | HBP1 | 0.810249 | 5 | 0 | 5 |
| LNX1 | CA13 | 0.80684 | 3 | 0 | 3 |
| LNX1 | NUCB2 | 0.802182 | 7 | 0 | 7 |
| LNX1 | CASC3 | 0.801892 | 3 | 0 | 3 |
| LNX1 | SLC16A6 | 0.800489 | 7 | 0 | 7 |
| LNX1 | RMND5B | 0.796774 | 7 | 0 | 6 |
| LNX1 | ALDH9A1 | 0.795352 | 7 | 0 | 7 |
| LNX1 | CD24 | 0.795346 | 5 | 0 | 5 |
| LNX1 | RRAGD | 0.794682 | 7 | 0 | 7 |
| LNX1 | NT5C2 | 0.793799 | 7 | 0 | 7 |
| LNX1 | GYS2 | 0.793225 | 6 | 0 | 6 |
| LNX1 | CAPN5 | 0.79292 | 7 | 0 | 7 |
For details and further investigation, click here
