| Full name: pleckstrin homology domain containing A7 | Alias Symbol: DKFZp686M22243 | ||
| Type: protein-coding gene | Cytoband: 11p15 | ||
| Entrez ID: 144100 | HGNC ID: HGNC:27049 | Ensembl Gene: ENSG00000166689 | OMIM ID: 612686 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHA7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHA7 | 144100 | 228450_at | -1.4324 | 0.0806 | |
| GSE26886 | PLEKHA7 | 144100 | 228450_at | -2.1679 | 0.0000 | |
| GSE45670 | PLEKHA7 | 144100 | 228450_at | -0.7999 | 0.0228 | |
| GSE53622 | PLEKHA7 | 144100 | 71955 | -1.6161 | 0.0000 | |
| GSE53624 | PLEKHA7 | 144100 | 71955 | -1.8847 | 0.0000 | |
| GSE63941 | PLEKHA7 | 144100 | 228450_at | 2.0778 | 0.0243 | |
| GSE77861 | PLEKHA7 | 144100 | 228450_at | -1.1014 | 0.0008 | |
| GSE97050 | PLEKHA7 | 144100 | A_24_P348806 | -0.5582 | 0.2316 | |
| SRP007169 | PLEKHA7 | 144100 | RNAseq | -1.7719 | 0.0001 | |
| SRP008496 | PLEKHA7 | 144100 | RNAseq | -1.9193 | 0.0000 | |
| SRP064894 | PLEKHA7 | 144100 | RNAseq | -2.0354 | 0.0000 | |
| SRP133303 | PLEKHA7 | 144100 | RNAseq | -1.6839 | 0.0000 | |
| SRP159526 | PLEKHA7 | 144100 | RNAseq | -2.5824 | 0.0000 | |
| SRP193095 | PLEKHA7 | 144100 | RNAseq | -1.5092 | 0.0000 | |
| SRP219564 | PLEKHA7 | 144100 | RNAseq | -2.0238 | 0.0021 | |
| TCGA | PLEKHA7 | 144100 | RNAseq | -0.4805 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 11.
Survival by PLEKHA7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHA7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHA7 | 144100 | 0 | 10 | 20 | |
| GSE20123 | PLEKHA7 | 144100 | 0 | 10 | 20 | |
| GSE43470 | PLEKHA7 | 144100 | 1 | 5 | 37 | |
| GSE46452 | PLEKHA7 | 144100 | 7 | 5 | 47 | |
| GSE47630 | PLEKHA7 | 144100 | 3 | 10 | 27 | |
| GSE54993 | PLEKHA7 | 144100 | 3 | 0 | 67 | |
| GSE54994 | PLEKHA7 | 144100 | 3 | 13 | 37 | |
| GSE60625 | PLEKHA7 | 144100 | 0 | 0 | 11 | |
| GSE74703 | PLEKHA7 | 144100 | 1 | 3 | 32 | |
| GSE74704 | PLEKHA7 | 144100 | 0 | 9 | 11 | |
| TCGA | PLEKHA7 | 144100 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 94; Total Number of normals: 365.
Somatic mutations of PLEKHA7:
Generating mutation plots.
Highly correlated genes for PLEKHA7:
Showing top 20/1618 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHA7 | GBP6 | 0.837244 | 4 | 0 | 4 |
| PLEKHA7 | CCNG2 | 0.834385 | 7 | 0 | 7 |
| PLEKHA7 | RAB25 | 0.833551 | 8 | 0 | 8 |
| PLEKHA7 | C18orf25 | 0.833506 | 7 | 0 | 7 |
| PLEKHA7 | SNORA68 | 0.833248 | 4 | 0 | 4 |
| PLEKHA7 | NAGK | 0.829405 | 7 | 0 | 7 |
| PLEKHA7 | SFTA2 | 0.829094 | 4 | 0 | 4 |
| PLEKHA7 | FCHO2 | 0.827175 | 7 | 0 | 7 |
| PLEKHA7 | LMO7 | 0.821579 | 6 | 0 | 6 |
| PLEKHA7 | VPS4B | 0.818368 | 7 | 0 | 7 |
| PLEKHA7 | FAM214A | 0.817877 | 6 | 0 | 6 |
| PLEKHA7 | DLG2 | 0.815389 | 6 | 0 | 6 |
| PLEKHA7 | FAM3B | 0.813688 | 6 | 0 | 6 |
| PLEKHA7 | CHP1 | 0.812816 | 6 | 0 | 6 |
| PLEKHA7 | ULK3 | 0.810136 | 7 | 0 | 7 |
| PLEKHA7 | CLDN7 | 0.808347 | 7 | 0 | 7 |
| PLEKHA7 | SCP2 | 0.808316 | 7 | 0 | 7 |
| PLEKHA7 | RANBP9 | 0.807734 | 7 | 0 | 7 |
| PLEKHA7 | SH3GLB1 | 0.806754 | 7 | 0 | 7 |
| PLEKHA7 | CMPK1 | 0.805896 | 7 | 0 | 7 |
For details and further investigation, click here
