| Full name: ankyrin 1 | Alias Symbol: SPH1 | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 286 | HGNC ID: HGNC:492 | Ensembl Gene: ENSG00000029534 | OMIM ID: 612641 |
| Drug and gene relationship at DGIdb | |||
ANK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of ANK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANK1 | 286 | 208352_x_at | -0.0482 | 0.9048 | |
| GSE20347 | ANK1 | 286 | 208353_x_at | 0.0276 | 0.7976 | |
| GSE23400 | ANK1 | 286 | 208352_x_at | -0.1485 | 0.0006 | |
| GSE26886 | ANK1 | 286 | 207087_x_at | 0.0888 | 0.6061 | |
| GSE29001 | ANK1 | 286 | 205391_x_at | -0.1151 | 0.5330 | |
| GSE38129 | ANK1 | 286 | 208353_x_at | -0.1253 | 0.1850 | |
| GSE45670 | ANK1 | 286 | 207087_x_at | 0.1944 | 0.1501 | |
| GSE53622 | ANK1 | 286 | 57061 | 0.4701 | 0.0000 | |
| GSE53624 | ANK1 | 286 | 57061 | 0.1539 | 0.1242 | |
| GSE63941 | ANK1 | 286 | 208352_x_at | 0.4758 | 0.0903 | |
| GSE77861 | ANK1 | 286 | 207087_x_at | 0.0008 | 0.9949 | |
| GSE97050 | ANK1 | 286 | A_33_P3376321 | 0.1627 | 0.7041 | |
| SRP133303 | ANK1 | 286 | RNAseq | 0.7895 | 0.0341 | |
| SRP159526 | ANK1 | 286 | RNAseq | 0.0159 | 0.9785 | |
| SRP193095 | ANK1 | 286 | RNAseq | 0.8187 | 0.0429 | |
| SRP219564 | ANK1 | 286 | RNAseq | 0.9695 | 0.1408 | |
| TCGA | ANK1 | 286 | RNAseq | -0.0687 | 0.8178 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ANK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANK1 | 286 | 10 | 5 | 15 | |
| GSE20123 | ANK1 | 286 | 10 | 6 | 14 | |
| GSE43470 | ANK1 | 286 | 9 | 6 | 28 | |
| GSE46452 | ANK1 | 286 | 19 | 5 | 35 | |
| GSE47630 | ANK1 | 286 | 22 | 1 | 17 | |
| GSE54993 | ANK1 | 286 | 1 | 16 | 53 | |
| GSE54994 | ANK1 | 286 | 19 | 7 | 27 | |
| GSE60625 | ANK1 | 286 | 3 | 0 | 8 | |
| GSE74703 | ANK1 | 286 | 8 | 5 | 23 | |
| GSE74704 | ANK1 | 286 | 9 | 2 | 9 | |
| TCGA | ANK1 | 286 | 38 | 21 | 37 |
Total number of gains: 148; Total number of losses: 74; Total Number of normals: 266.
Somatic mutations of ANK1:
Generating mutation plots.
Highly correlated genes for ANK1:
Showing top 20/758 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANK1 | UCMA | 0.682946 | 3 | 0 | 3 |
| ANK1 | LIPF | 0.665536 | 3 | 0 | 3 |
| ANK1 | RARA | 0.665077 | 4 | 0 | 4 |
| ANK1 | CNTN2 | 0.661306 | 6 | 0 | 5 |
| ANK1 | HSPB6 | 0.653386 | 4 | 0 | 4 |
| ANK1 | RPRML | 0.650005 | 3 | 0 | 3 |
| ANK1 | TECTB | 0.649514 | 3 | 0 | 3 |
| ANK1 | TMEM105 | 0.645325 | 4 | 0 | 3 |
| ANK1 | OVGP1 | 0.645051 | 5 | 0 | 5 |
| ANK1 | HRC | 0.644421 | 4 | 0 | 4 |
| ANK1 | LGI2 | 0.644227 | 5 | 0 | 4 |
| ANK1 | NYX | 0.641632 | 5 | 0 | 4 |
| ANK1 | OLFM1 | 0.641372 | 3 | 0 | 3 |
| ANK1 | OR10H3 | 0.63788 | 5 | 0 | 4 |
| ANK1 | PHLDB1 | 0.632679 | 6 | 0 | 5 |
| ANK1 | OR10H1 | 0.632324 | 6 | 0 | 5 |
| ANK1 | TAOK2 | 0.631084 | 3 | 0 | 3 |
| ANK1 | KLK14 | 0.630921 | 6 | 0 | 5 |
| ANK1 | CD4 | 0.630543 | 4 | 0 | 3 |
| ANK1 | GPA33 | 0.62994 | 4 | 0 | 3 |
For details and further investigation, click here
