| Full name: histidine rich calcium binding protein | Alias Symbol: MGC133236 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 3270 | HGNC ID: HGNC:5178 | Ensembl Gene: ENSG00000130528 | OMIM ID: 142705 |
| Drug and gene relationship at DGIdb | |||
Expression of HRC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HRC | 3270 | 207066_at | -0.3207 | 0.2386 | |
| GSE20347 | HRC | 3270 | 207066_at | -0.0237 | 0.7990 | |
| GSE23400 | HRC | 3270 | 207066_at | -0.2340 | 0.0000 | |
| GSE26886 | HRC | 3270 | 207066_at | -0.0595 | 0.5313 | |
| GSE29001 | HRC | 3270 | 207066_at | -0.1575 | 0.2844 | |
| GSE38129 | HRC | 3270 | 207066_at | -0.2660 | 0.0022 | |
| GSE45670 | HRC | 3270 | 207066_at | -0.2753 | 0.0024 | |
| GSE53622 | HRC | 3270 | 46853 | -0.5616 | 0.0000 | |
| GSE53624 | HRC | 3270 | 46853 | -1.8421 | 0.0000 | |
| GSE63941 | HRC | 3270 | 207066_at | -0.0641 | 0.6676 | |
| GSE77861 | HRC | 3270 | 207066_at | -0.0730 | 0.3877 | |
| GSE97050 | HRC | 3270 | A_23_P142125 | -0.3265 | 0.1891 | |
| SRP133303 | HRC | 3270 | RNAseq | -0.7200 | 0.0045 | |
| SRP159526 | HRC | 3270 | RNAseq | -1.5959 | 0.0045 | |
| SRP193095 | HRC | 3270 | RNAseq | -0.1492 | 0.3925 | |
| SRP219564 | HRC | 3270 | RNAseq | -0.3101 | 0.6926 | |
| TCGA | HRC | 3270 | RNAseq | -1.6442 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by HRC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HRC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HRC | 3270 | 4 | 4 | 22 | |
| GSE20123 | HRC | 3270 | 4 | 3 | 23 | |
| GSE43470 | HRC | 3270 | 4 | 10 | 29 | |
| GSE46452 | HRC | 3270 | 45 | 1 | 13 | |
| GSE47630 | HRC | 3270 | 10 | 6 | 24 | |
| GSE54993 | HRC | 3270 | 17 | 4 | 49 | |
| GSE54994 | HRC | 3270 | 4 | 14 | 35 | |
| GSE60625 | HRC | 3270 | 9 | 0 | 2 | |
| GSE74703 | HRC | 3270 | 4 | 7 | 25 | |
| GSE74704 | HRC | 3270 | 4 | 1 | 15 | |
| TCGA | HRC | 3270 | 14 | 18 | 64 |
Total number of gains: 119; Total number of losses: 68; Total Number of normals: 301.
Somatic mutations of HRC:
Generating mutation plots.
Highly correlated genes for HRC:
Showing top 20/1098 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HRC | BARHL2 | 0.817261 | 3 | 0 | 3 |
| HRC | FSIP1 | 0.812844 | 3 | 0 | 3 |
| HRC | NPR2 | 0.809023 | 3 | 0 | 3 |
| HRC | P2RX6 | 0.789607 | 3 | 0 | 3 |
| HRC | OBSL1 | 0.788321 | 3 | 0 | 3 |
| HRC | C9orf106 | 0.778949 | 3 | 0 | 3 |
| HRC | MEPE | 0.776786 | 4 | 0 | 4 |
| HRC | GPR88 | 0.776673 | 4 | 0 | 4 |
| HRC | OR10G8 | 0.775368 | 3 | 0 | 3 |
| HRC | NT5C1A | 0.771536 | 3 | 0 | 3 |
| HRC | CDC42EP2 | 0.769997 | 4 | 0 | 4 |
| HRC | ANGPT4 | 0.768977 | 4 | 0 | 4 |
| HRC | PRRT2 | 0.768313 | 3 | 0 | 3 |
| HRC | FAM163B | 0.767436 | 3 | 0 | 3 |
| HRC | OR2Z1 | 0.765558 | 3 | 0 | 3 |
| HRC | RNF186 | 0.763768 | 4 | 0 | 4 |
| HRC | OR10G3 | 0.7565 | 3 | 0 | 3 |
| HRC | KRTAP5-9 | 0.751454 | 3 | 0 | 3 |
| HRC | BRINP2 | 0.75106 | 3 | 0 | 3 |
| HRC | OTOF | 0.74899 | 6 | 0 | 6 |
For details and further investigation, click here
