| Full name: retinoic acid receptor alpha | Alias Symbol: RAR|NR1B1 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 5914 | HGNC ID: HGNC:9864 | Ensembl Gene: ENSG00000131759 | OMIM ID: 180240 |
| Related drugs: ACITRETIN, ADAPALENE, ALITRETINOIN, ARSENIC TRIOXIDE, CEFPIRAMIDE, CEFTAZIDIME, CETUXIMAB, CHEMBL2385269, CHEMBL288436, CHEMBL358145... [more] | |||
Screen Evidence:
| |||
RARA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05221 | Acute myeloid leukemia |
Expression of RARA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RARA | 5914 | 216300_x_at | 0.2081 | 0.3937 | |
| GSE20347 | RARA | 5914 | 203750_s_at | -0.0350 | 0.6528 | |
| GSE23400 | RARA | 5914 | 216300_x_at | 0.1041 | 0.0214 | |
| GSE26886 | RARA | 5914 | 203750_s_at | 0.0482 | 0.7751 | |
| GSE29001 | RARA | 5914 | 211605_s_at | -0.1261 | 0.3822 | |
| GSE38129 | RARA | 5914 | 216300_x_at | 0.1673 | 0.2044 | |
| GSE45670 | RARA | 5914 | 216300_x_at | -0.0098 | 0.9312 | |
| GSE53622 | RARA | 5914 | 5323 | -0.0807 | 0.3119 | |
| GSE53624 | RARA | 5914 | 79676 | 0.3858 | 0.0000 | |
| GSE63941 | RARA | 5914 | 203750_s_at | 0.1278 | 0.4890 | |
| GSE77861 | RARA | 5914 | 203750_s_at | -0.1309 | 0.3361 | |
| GSE97050 | RARA | 5914 | A_23_P207842 | 0.0828 | 0.7098 | |
| SRP007169 | RARA | 5914 | RNAseq | 1.8362 | 0.0028 | |
| SRP008496 | RARA | 5914 | RNAseq | 1.2773 | 0.0039 | |
| SRP064894 | RARA | 5914 | RNAseq | 0.4084 | 0.0870 | |
| SRP133303 | RARA | 5914 | RNAseq | 0.0209 | 0.9177 | |
| SRP159526 | RARA | 5914 | RNAseq | 0.5191 | 0.1919 | |
| SRP193095 | RARA | 5914 | RNAseq | 0.6541 | 0.0044 | |
| SRP219564 | RARA | 5914 | RNAseq | 0.2166 | 0.7073 | |
| TCGA | RARA | 5914 | RNAseq | -0.1037 | 0.0512 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RARA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RARA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RARA | 5914 | 8 | 1 | 21 | |
| GSE20123 | RARA | 5914 | 8 | 1 | 21 | |
| GSE43470 | RARA | 5914 | 1 | 2 | 40 | |
| GSE46452 | RARA | 5914 | 34 | 0 | 25 | |
| GSE47630 | RARA | 5914 | 8 | 1 | 31 | |
| GSE54993 | RARA | 5914 | 3 | 4 | 63 | |
| GSE54994 | RARA | 5914 | 8 | 5 | 40 | |
| GSE60625 | RARA | 5914 | 4 | 0 | 7 | |
| GSE74703 | RARA | 5914 | 1 | 1 | 34 | |
| GSE74704 | RARA | 5914 | 5 | 1 | 14 | |
| TCGA | RARA | 5914 | 22 | 8 | 66 |
Total number of gains: 102; Total number of losses: 24; Total Number of normals: 362.
Somatic mutations of RARA:
Generating mutation plots.
Highly correlated genes for RARA:
Showing top 20/423 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RARA | LIPF | 0.866724 | 3 | 0 | 3 |
| RARA | PROX1 | 0.852154 | 3 | 0 | 3 |
| RARA | TPSG1 | 0.764126 | 4 | 0 | 4 |
| RARA | NINJ1 | 0.755263 | 3 | 0 | 3 |
| RARA | HIC1 | 0.754564 | 3 | 0 | 3 |
| RARA | STARD13 | 0.754135 | 3 | 0 | 3 |
| RARA | DNAH11 | 0.750253 | 3 | 0 | 3 |
| RARA | PCBP3 | 0.749748 | 3 | 0 | 3 |
| RARA | CRYBB2 | 0.746887 | 5 | 0 | 5 |
| RARA | EXOC3L1 | 0.742254 | 3 | 0 | 3 |
| RARA | PNMT | 0.737631 | 4 | 0 | 4 |
| RARA | ZNF286A | 0.733283 | 3 | 0 | 3 |
| RARA | PSKH1 | 0.731009 | 4 | 0 | 3 |
| RARA | KDM6B | 0.724393 | 3 | 0 | 3 |
| RARA | PLCB2 | 0.724349 | 3 | 0 | 3 |
| RARA | ZNF747 | 0.723748 | 3 | 0 | 3 |
| RARA | MYADML2 | 0.723201 | 4 | 0 | 4 |
| RARA | COX6A2 | 0.720009 | 4 | 0 | 4 |
| RARA | MUL1 | 0.716152 | 3 | 0 | 3 |
| RARA | MED9 | 0.712168 | 3 | 0 | 3 |
For details and further investigation, click here
