| Full name: heat shock protein family B (small) member 6 | Alias Symbol: FLJ32389|Hsp20|PPP1R91 | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 126393 | HGNC ID: HGNC:26511 | Ensembl Gene: ENSG00000004776 | OMIM ID: 610695 |
| Drug and gene relationship at DGIdb | |||
Expression of HSPB6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSPB6 | 126393 | 226304_at | -1.4268 | 0.0623 | |
| GSE20347 | HSPB6 | 126393 | 214767_s_at | -0.0552 | 0.6306 | |
| GSE23400 | HSPB6 | 126393 | 214767_s_at | -0.5481 | 0.0000 | |
| GSE26886 | HSPB6 | 126393 | 214767_s_at | -0.0191 | 0.9166 | |
| GSE29001 | HSPB6 | 126393 | 214767_s_at | -0.2124 | 0.2796 | |
| GSE38129 | HSPB6 | 126393 | 214767_s_at | -0.7493 | 0.0004 | |
| GSE45670 | HSPB6 | 126393 | 214767_s_at | -0.2167 | 0.0424 | |
| GSE53622 | HSPB6 | 126393 | 13797 | -3.1976 | 0.0000 | |
| GSE53624 | HSPB6 | 126393 | 13797 | -2.4566 | 0.0000 | |
| GSE63941 | HSPB6 | 126393 | 214767_s_at | 0.0682 | 0.7316 | |
| GSE77861 | HSPB6 | 126393 | 226304_at | -0.0643 | 0.7012 | |
| GSE97050 | HSPB6 | 126393 | A_24_P308029 | -1.2977 | 0.1281 | |
| SRP064894 | HSPB6 | 126393 | RNAseq | -1.5004 | 0.0025 | |
| SRP133303 | HSPB6 | 126393 | RNAseq | -3.0313 | 0.0000 | |
| SRP159526 | HSPB6 | 126393 | RNAseq | -1.5459 | 0.0782 | |
| SRP219564 | HSPB6 | 126393 | RNAseq | -1.6402 | 0.2228 | |
| TCGA | HSPB6 | 126393 | RNAseq | -1.2947 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by HSPB6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSPB6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSPB6 | 126393 | 7 | 4 | 19 | |
| GSE20123 | HSPB6 | 126393 | 7 | 3 | 20 | |
| GSE43470 | HSPB6 | 126393 | 3 | 7 | 33 | |
| GSE46452 | HSPB6 | 126393 | 48 | 1 | 10 | |
| GSE47630 | HSPB6 | 126393 | 9 | 5 | 26 | |
| GSE54993 | HSPB6 | 126393 | 17 | 3 | 50 | |
| GSE54994 | HSPB6 | 126393 | 6 | 9 | 38 | |
| GSE60625 | HSPB6 | 126393 | 9 | 0 | 2 | |
| GSE74703 | HSPB6 | 126393 | 3 | 4 | 29 | |
| GSE74704 | HSPB6 | 126393 | 6 | 1 | 13 | |
| TCGA | HSPB6 | 126393 | 22 | 10 | 64 |
Total number of gains: 137; Total number of losses: 47; Total Number of normals: 304.
Somatic mutations of HSPB6:
Generating mutation plots.
Highly correlated genes for HSPB6:
Showing top 20/1295 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSPB6 | CLEC3B | 0.880148 | 3 | 0 | 3 |
| HSPB6 | CYP21A2 | 0.872966 | 3 | 0 | 3 |
| HSPB6 | MRVI1 | 0.851966 | 5 | 0 | 5 |
| HSPB6 | PI16 | 0.835699 | 4 | 0 | 4 |
| HSPB6 | MIR100HG | 0.821749 | 3 | 0 | 3 |
| HSPB6 | ANGPTL1 | 0.814435 | 5 | 0 | 4 |
| HSPB6 | TTLL11 | 0.795977 | 3 | 0 | 3 |
| HSPB6 | BOC | 0.794573 | 4 | 0 | 4 |
| HSPB6 | LRFN5 | 0.794503 | 4 | 0 | 4 |
| HSPB6 | PDZRN4 | 0.787033 | 7 | 0 | 6 |
| HSPB6 | HLF | 0.782746 | 6 | 0 | 5 |
| HSPB6 | EIF4E3 | 0.777005 | 5 | 0 | 4 |
| HSPB6 | LRRN4CL | 0.776226 | 4 | 0 | 4 |
| HSPB6 | S1PR3 | 0.774758 | 3 | 0 | 3 |
| HSPB6 | MYOCD | 0.774345 | 6 | 0 | 5 |
| HSPB6 | SMOC2 | 0.769487 | 4 | 0 | 4 |
| HSPB6 | ACTBL2 | 0.767448 | 3 | 0 | 3 |
| HSPB6 | FILIP1 | 0.766446 | 4 | 0 | 4 |
| HSPB6 | AOC3 | 0.765413 | 8 | 0 | 7 |
| HSPB6 | SLMAP | 0.764669 | 5 | 0 | 4 |
For details and further investigation, click here
