| Full name: CD4 molecule | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 920 | HGNC ID: HGNC:1678 | Ensembl Gene: ENSG00000010610 | OMIM ID: 186940 |
| Drug and gene relationship at DGIdb | |||
CD4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04660 | T cell receptor signaling pathway |
Expression of CD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD4 | 920 | 203547_at | 0.3813 | 0.5327 | |
| GSE20347 | CD4 | 920 | 203547_at | 0.0529 | 0.6642 | |
| GSE23400 | CD4 | 920 | 203547_at | 0.0093 | 0.8554 | |
| GSE26886 | CD4 | 920 | 203547_at | -0.1423 | 0.4666 | |
| GSE29001 | CD4 | 920 | 203547_at | -0.0873 | 0.6917 | |
| GSE38129 | CD4 | 920 | 203547_at | 0.0509 | 0.6998 | |
| GSE45670 | CD4 | 920 | 203547_at | -0.0398 | 0.6482 | |
| GSE53622 | CD4 | 920 | 62658 | -0.0688 | 0.2860 | |
| GSE53624 | CD4 | 920 | 62658 | -0.1041 | 0.0384 | |
| GSE63941 | CD4 | 920 | 203547_at | 0.2769 | 0.0743 | |
| GSE77861 | CD4 | 920 | 203547_at | -0.0422 | 0.7603 | |
| GSE97050 | CD4 | 920 | A_24_P295999 | -0.0025 | 0.9933 | |
| SRP007169 | CD4 | 920 | RNAseq | 1.3841 | 0.0657 | |
| SRP008496 | CD4 | 920 | RNAseq | 1.0055 | 0.0263 | |
| SRP064894 | CD4 | 920 | RNAseq | 0.8097 | 0.0104 | |
| SRP133303 | CD4 | 920 | RNAseq | 0.1061 | 0.6798 | |
| SRP159526 | CD4 | 920 | RNAseq | -0.0905 | 0.9041 | |
| SRP193095 | CD4 | 920 | RNAseq | 0.2074 | 0.2500 | |
| SRP219564 | CD4 | 920 | RNAseq | 1.2523 | 0.0145 | |
| TCGA | CD4 | 920 | RNAseq | 0.2334 | 0.0463 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD4 | 920 | 9 | 3 | 18 | |
| GSE20123 | CD4 | 920 | 9 | 3 | 18 | |
| GSE43470 | CD4 | 920 | 8 | 3 | 32 | |
| GSE46452 | CD4 | 920 | 10 | 1 | 48 | |
| GSE47630 | CD4 | 920 | 12 | 2 | 26 | |
| GSE54993 | CD4 | 920 | 1 | 10 | 59 | |
| GSE54994 | CD4 | 920 | 10 | 2 | 41 | |
| GSE60625 | CD4 | 920 | 0 | 1 | 10 | |
| GSE74703 | CD4 | 920 | 7 | 2 | 27 | |
| GSE74704 | CD4 | 920 | 5 | 3 | 12 | |
| TCGA | CD4 | 920 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.
Somatic mutations of CD4:
Generating mutation plots.
Highly correlated genes for CD4:
Showing top 20/460 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD4 | MOGAT2 | 0.709036 | 3 | 0 | 3 |
| CD4 | CA7 | 0.701545 | 4 | 0 | 4 |
| CD4 | TMEM229B | 0.70041 | 3 | 0 | 3 |
| CD4 | EPN1 | 0.688365 | 3 | 0 | 3 |
| CD4 | LENEP | 0.687628 | 3 | 0 | 3 |
| CD4 | PHLDB1 | 0.677857 | 4 | 0 | 4 |
| CD4 | AIPL1 | 0.67478 | 3 | 0 | 3 |
| CD4 | SNX20 | 0.670923 | 3 | 0 | 3 |
| CD4 | CXCL16 | 0.670537 | 3 | 0 | 3 |
| CD4 | CD27 | 0.670207 | 7 | 0 | 6 |
| CD4 | BTBD2 | 0.665763 | 5 | 0 | 4 |
| CD4 | MLN | 0.66387 | 3 | 0 | 3 |
| CD4 | TRANK1 | 0.66198 | 5 | 0 | 4 |
| CD4 | RAB4B | 0.659625 | 3 | 0 | 3 |
| CD4 | SUCNR1 | 0.659622 | 4 | 0 | 4 |
| CD4 | NCKAP1L | 0.657247 | 8 | 0 | 7 |
| CD4 | IGLL1 | 0.657023 | 4 | 0 | 3 |
| CD4 | KIF25 | 0.656451 | 3 | 0 | 3 |
| CD4 | LAIR1 | 0.655767 | 8 | 0 | 6 |
| CD4 | E2F4 | 0.655643 | 5 | 0 | 5 |
For details and further investigation, click here
