| Full name: leucine rich repeat LGI family member 2 | Alias Symbol: KIAA1916|FLJ10675 | ||
| Type: protein-coding gene | Cytoband: 4p15.2 | ||
| Entrez ID: 55203 | HGNC ID: HGNC:18710 | Ensembl Gene: ENSG00000153012 | OMIM ID: 608301 |
| Drug and gene relationship at DGIdb | |||
Expression of LGI2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LGI2 | 55203 | 219699_at | -0.0656 | 0.9072 | |
| GSE20347 | LGI2 | 55203 | 219699_at | 0.0143 | 0.9049 | |
| GSE23400 | LGI2 | 55203 | 219699_at | -0.0803 | 0.1790 | |
| GSE26886 | LGI2 | 55203 | 219699_at | 0.2268 | 0.0365 | |
| GSE29001 | LGI2 | 55203 | 219699_at | -0.0514 | 0.8385 | |
| GSE38129 | LGI2 | 55203 | 219699_at | -0.1471 | 0.3104 | |
| GSE45670 | LGI2 | 55203 | 219699_at | -0.0665 | 0.4206 | |
| GSE53622 | LGI2 | 55203 | 144713 | -0.2245 | 0.3413 | |
| GSE53624 | LGI2 | 55203 | 144713 | 0.2254 | 0.1196 | |
| GSE63941 | LGI2 | 55203 | 219699_at | 0.0462 | 0.8171 | |
| GSE77861 | LGI2 | 55203 | 219699_at | -0.0144 | 0.9199 | |
| GSE97050 | LGI2 | 55203 | A_33_P3393655 | -0.3100 | 0.5659 | |
| SRP007169 | LGI2 | 55203 | RNAseq | 4.0592 | 0.0007 | |
| SRP064894 | LGI2 | 55203 | RNAseq | 1.8839 | 0.0000 | |
| SRP133303 | LGI2 | 55203 | RNAseq | 0.5911 | 0.2987 | |
| SRP159526 | LGI2 | 55203 | RNAseq | 0.7779 | 0.3181 | |
| SRP219564 | LGI2 | 55203 | RNAseq | 0.3882 | 0.7858 | |
| TCGA | LGI2 | 55203 | RNAseq | -0.3470 | 0.2309 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LGI2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LGI2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LGI2 | 55203 | 0 | 18 | 12 | |
| GSE20123 | LGI2 | 55203 | 0 | 16 | 14 | |
| GSE43470 | LGI2 | 55203 | 0 | 15 | 28 | |
| GSE46452 | LGI2 | 55203 | 1 | 36 | 22 | |
| GSE47630 | LGI2 | 55203 | 1 | 19 | 20 | |
| GSE54993 | LGI2 | 55203 | 10 | 0 | 60 | |
| GSE54994 | LGI2 | 55203 | 5 | 11 | 37 | |
| GSE60625 | LGI2 | 55203 | 0 | 0 | 11 | |
| GSE74703 | LGI2 | 55203 | 0 | 13 | 23 | |
| GSE74704 | LGI2 | 55203 | 0 | 10 | 10 | |
| TCGA | LGI2 | 55203 | 11 | 47 | 38 |
Total number of gains: 28; Total number of losses: 185; Total Number of normals: 275.
Somatic mutations of LGI2:
Generating mutation plots.
Highly correlated genes for LGI2:
Showing top 20/1042 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LGI2 | CISH | 0.799884 | 3 | 0 | 3 |
| LGI2 | DERL3 | 0.774154 | 3 | 0 | 3 |
| LGI2 | MAPK11 | 0.771999 | 4 | 0 | 4 |
| LGI2 | SIN3B | 0.741924 | 3 | 0 | 3 |
| LGI2 | B9D2 | 0.741852 | 3 | 0 | 3 |
| LGI2 | GSX1 | 0.73955 | 3 | 0 | 3 |
| LGI2 | NFAM1 | 0.737691 | 3 | 0 | 3 |
| LGI2 | SF3A2 | 0.737536 | 3 | 0 | 3 |
| LGI2 | R3HDM2 | 0.737273 | 3 | 0 | 3 |
| LGI2 | ZMIZ2 | 0.73332 | 3 | 0 | 3 |
| LGI2 | PPP1R15A | 0.733313 | 3 | 0 | 3 |
| LGI2 | GNG2 | 0.730377 | 3 | 0 | 3 |
| LGI2 | NAGLU | 0.723727 | 3 | 0 | 3 |
| LGI2 | C2orf88 | 0.71897 | 4 | 0 | 3 |
| LGI2 | GDF5 | 0.717567 | 3 | 0 | 3 |
| LGI2 | TSPAN18 | 0.717385 | 3 | 0 | 3 |
| LGI2 | DCTN1 | 0.717181 | 3 | 0 | 3 |
| LGI2 | CYSLTR2 | 0.716755 | 4 | 0 | 3 |
| LGI2 | FKBP10 | 0.713469 | 3 | 0 | 3 |
| LGI2 | RGMB | 0.709191 | 4 | 0 | 3 |
For details and further investigation, click here
