| Full name: pleckstrin homology like domain family B member 1 | Alias Symbol: FLJ00141|LL5a|KIAA0638 | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 23187 | HGNC ID: HGNC:23697 | Ensembl Gene: ENSG00000019144 | OMIM ID: 612834 |
| Drug and gene relationship at DGIdb | |||
Expression of PHLDB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHLDB1 | 23187 | 216102_at | -0.2499 | 0.3477 | |
| GSE20347 | PHLDB1 | 23187 | 216102_at | -0.1576 | 0.2909 | |
| GSE23400 | PHLDB1 | 23187 | 216102_at | -0.2978 | 0.0000 | |
| GSE26886 | PHLDB1 | 23187 | 216102_at | -0.2140 | 0.1757 | |
| GSE29001 | PHLDB1 | 23187 | 216102_at | -0.2660 | 0.1449 | |
| GSE38129 | PHLDB1 | 23187 | 216102_at | -0.2533 | 0.0410 | |
| GSE45670 | PHLDB1 | 23187 | 216102_at | 0.0855 | 0.4397 | |
| GSE53622 | PHLDB1 | 23187 | 117489 | 0.6007 | 0.0000 | |
| GSE53624 | PHLDB1 | 23187 | 97794 | 0.4194 | 0.0000 | |
| GSE63941 | PHLDB1 | 23187 | 216102_at | 0.0562 | 0.7727 | |
| GSE77861 | PHLDB1 | 23187 | 216102_at | -0.2147 | 0.1467 | |
| GSE97050 | PHLDB1 | 23187 | A_23_P24555 | 0.1343 | 0.5691 | |
| SRP007169 | PHLDB1 | 23187 | RNAseq | 1.5408 | 0.0003 | |
| SRP008496 | PHLDB1 | 23187 | RNAseq | 2.2476 | 0.0000 | |
| SRP064894 | PHLDB1 | 23187 | RNAseq | 0.5700 | 0.0348 | |
| SRP133303 | PHLDB1 | 23187 | RNAseq | 0.2086 | 0.4712 | |
| SRP159526 | PHLDB1 | 23187 | RNAseq | 0.3710 | 0.3011 | |
| SRP193095 | PHLDB1 | 23187 | RNAseq | 1.0312 | 0.0000 | |
| SRP219564 | PHLDB1 | 23187 | RNAseq | 0.1972 | 0.6699 | |
| TCGA | PHLDB1 | 23187 | RNAseq | -0.1985 | 0.0155 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PHLDB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHLDB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHLDB1 | 23187 | 2 | 11 | 17 | |
| GSE20123 | PHLDB1 | 23187 | 2 | 11 | 17 | |
| GSE43470 | PHLDB1 | 23187 | 2 | 9 | 32 | |
| GSE46452 | PHLDB1 | 23187 | 3 | 26 | 30 | |
| GSE47630 | PHLDB1 | 23187 | 2 | 19 | 19 | |
| GSE54993 | PHLDB1 | 23187 | 10 | 0 | 60 | |
| GSE54994 | PHLDB1 | 23187 | 5 | 19 | 29 | |
| GSE60625 | PHLDB1 | 23187 | 0 | 3 | 8 | |
| GSE74703 | PHLDB1 | 23187 | 1 | 6 | 29 | |
| GSE74704 | PHLDB1 | 23187 | 1 | 7 | 12 | |
| TCGA | PHLDB1 | 23187 | 4 | 51 | 41 |
Total number of gains: 32; Total number of losses: 162; Total Number of normals: 294.
Somatic mutations of PHLDB1:
Generating mutation plots.
Highly correlated genes for PHLDB1:
Showing top 20/990 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHLDB1 | FLI1 | 0.783122 | 4 | 0 | 4 |
| PHLDB1 | LIPF | 0.782722 | 4 | 0 | 4 |
| PHLDB1 | NPAP1 | 0.777684 | 4 | 0 | 4 |
| PHLDB1 | CCDC87 | 0.77402 | 4 | 0 | 4 |
| PHLDB1 | SCNN1G | 0.763856 | 5 | 0 | 5 |
| PHLDB1 | MTAP | 0.763484 | 5 | 0 | 5 |
| PHLDB1 | HOXA3 | 0.760234 | 5 | 0 | 5 |
| PHLDB1 | DRD5 | 0.758032 | 6 | 0 | 6 |
| PHLDB1 | CSRP3 | 0.753899 | 4 | 0 | 4 |
| PHLDB1 | AKAP7 | 0.751844 | 4 | 0 | 4 |
| PHLDB1 | UBR4 | 0.751811 | 3 | 0 | 3 |
| PHLDB1 | HLA-DOA | 0.748957 | 6 | 0 | 6 |
| PHLDB1 | ENTPD2 | 0.74749 | 6 | 0 | 6 |
| PHLDB1 | RHAG | 0.747426 | 3 | 0 | 3 |
| PHLDB1 | NCR2 | 0.747175 | 5 | 0 | 4 |
| PHLDB1 | GDF5 | 0.746541 | 5 | 0 | 4 |
| PHLDB1 | ASIC4 | 0.746269 | 4 | 0 | 4 |
| PHLDB1 | FSTL4 | 0.74625 | 4 | 0 | 4 |
| PHLDB1 | ZFP36L2 | 0.74075 | 3 | 0 | 3 |
| PHLDB1 | BTN1A1 | 0.740428 | 6 | 0 | 5 |
For details and further investigation, click here
