| Full name: amyloid beta precursor protein binding family B member 1 | Alias Symbol: Fe65 | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 322 | HGNC ID: HGNC:581 | Ensembl Gene: ENSG00000166313 | OMIM ID: 602709 |
| Drug and gene relationship at DGIdb | |||
APBB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05010 | Alzheimer's disease |
Expression of APBB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APBB1 | 322 | 202652_at | -0.3128 | 0.3424 | |
| GSE20347 | APBB1 | 322 | 202652_at | -0.0588 | 0.5189 | |
| GSE23400 | APBB1 | 322 | 202652_at | -0.1441 | 0.0010 | |
| GSE26886 | APBB1 | 322 | 202652_at | 0.3186 | 0.0046 | |
| GSE29001 | APBB1 | 322 | 202652_at | -0.2293 | 0.1531 | |
| GSE38129 | APBB1 | 322 | 202652_at | -0.3006 | 0.0056 | |
| GSE45670 | APBB1 | 322 | 202652_at | -0.3527 | 0.0028 | |
| GSE53622 | APBB1 | 322 | 38192 | -0.5005 | 0.0001 | |
| GSE53624 | APBB1 | 322 | 38192 | -0.3498 | 0.0000 | |
| GSE63941 | APBB1 | 322 | 202652_at | -1.2122 | 0.0011 | |
| GSE77861 | APBB1 | 322 | 202652_at | 0.0636 | 0.7343 | |
| GSE97050 | APBB1 | 322 | A_23_P1998 | -0.6532 | 0.1856 | |
| SRP007169 | APBB1 | 322 | RNAseq | -0.2676 | 0.7066 | |
| SRP064894 | APBB1 | 322 | RNAseq | 0.0807 | 0.8225 | |
| SRP133303 | APBB1 | 322 | RNAseq | -0.4594 | 0.2389 | |
| SRP159526 | APBB1 | 322 | RNAseq | -0.2525 | 0.3980 | |
| SRP193095 | APBB1 | 322 | RNAseq | -0.0510 | 0.8320 | |
| SRP219564 | APBB1 | 322 | RNAseq | -1.0461 | 0.2140 | |
| TCGA | APBB1 | 322 | RNAseq | -0.6212 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by APBB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APBB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APBB1 | 322 | 1 | 11 | 18 | |
| GSE20123 | APBB1 | 322 | 1 | 11 | 18 | |
| GSE43470 | APBB1 | 322 | 1 | 8 | 34 | |
| GSE46452 | APBB1 | 322 | 7 | 8 | 44 | |
| GSE47630 | APBB1 | 322 | 2 | 12 | 26 | |
| GSE54993 | APBB1 | 322 | 3 | 1 | 66 | |
| GSE54994 | APBB1 | 322 | 2 | 12 | 39 | |
| GSE60625 | APBB1 | 322 | 0 | 0 | 11 | |
| GSE74703 | APBB1 | 322 | 1 | 6 | 29 | |
| GSE74704 | APBB1 | 322 | 0 | 8 | 12 | |
| TCGA | APBB1 | 322 | 8 | 39 | 49 |
Total number of gains: 26; Total number of losses: 116; Total Number of normals: 346.
Somatic mutations of APBB1:
Generating mutation plots.
Highly correlated genes for APBB1:
Showing top 20/898 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APBB1 | CORO6 | 0.782841 | 3 | 0 | 3 |
| APBB1 | MICU3 | 0.765927 | 3 | 0 | 3 |
| APBB1 | NKD1 | 0.755995 | 3 | 0 | 3 |
| APBB1 | RILP | 0.740385 | 3 | 0 | 3 |
| APBB1 | KATNAL1 | 0.722285 | 4 | 0 | 4 |
| APBB1 | JAZF1 | 0.721256 | 4 | 0 | 4 |
| APBB1 | CRLF1 | 0.719865 | 3 | 0 | 3 |
| APBB1 | IQUB | 0.716359 | 3 | 0 | 3 |
| APBB1 | RASD2 | 0.715982 | 3 | 0 | 3 |
| APBB1 | DACT3 | 0.701551 | 8 | 0 | 6 |
| APBB1 | LOH12CR2 | 0.699379 | 4 | 0 | 3 |
| APBB1 | SPRED3 | 0.698484 | 3 | 0 | 3 |
| APBB1 | SNPH | 0.694602 | 12 | 0 | 10 |
| APBB1 | FBN1 | 0.69186 | 4 | 0 | 4 |
| APBB1 | ZBTB47 | 0.687645 | 4 | 0 | 4 |
| APBB1 | RNF150 | 0.682666 | 6 | 0 | 5 |
| APBB1 | KIAA0408 | 0.679124 | 6 | 0 | 5 |
| APBB1 | TCEAL3 | 0.675665 | 3 | 0 | 3 |
| APBB1 | INMT | 0.674687 | 8 | 0 | 7 |
| APBB1 | PLA2G5 | 0.674679 | 9 | 0 | 8 |
For details and further investigation, click here
