| Full name: NKD inhibitor of WNT signaling pathway 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q12.1 | ||
| Entrez ID: 85407 | HGNC ID: HGNC:17045 | Ensembl Gene: ENSG00000140807 | OMIM ID: 607851 |
| Drug and gene relationship at DGIdb | |||
NKD1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway | |
| hsa04390 | Hippo signaling pathway |
Expression of NKD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NKD1 | 85407 | 232203_at | -0.1084 | 0.7701 | |
| GSE26886 | NKD1 | 85407 | 1553115_at | -0.0185 | 0.9323 | |
| GSE45670 | NKD1 | 85407 | 1553115_at | -0.0457 | 0.7382 | |
| GSE53622 | NKD1 | 85407 | 6735 | -0.0483 | 0.7875 | |
| GSE53624 | NKD1 | 85407 | 6735 | 0.2340 | 0.0096 | |
| GSE63941 | NKD1 | 85407 | 232203_at | 0.4301 | 0.0589 | |
| GSE77861 | NKD1 | 85407 | 1553115_at | -0.2150 | 0.0988 | |
| GSE97050 | NKD1 | 85407 | A_23_P429449 | -0.7014 | 0.2579 | |
| SRP007169 | NKD1 | 85407 | RNAseq | 1.1457 | 0.0842 | |
| SRP008496 | NKD1 | 85407 | RNAseq | 2.0728 | 0.0003 | |
| SRP064894 | NKD1 | 85407 | RNAseq | -0.3209 | 0.4025 | |
| SRP133303 | NKD1 | 85407 | RNAseq | -0.8000 | 0.0103 | |
| SRP159526 | NKD1 | 85407 | RNAseq | -0.8946 | 0.0183 | |
| SRP193095 | NKD1 | 85407 | RNAseq | 0.9105 | 0.0001 | |
| SRP219564 | NKD1 | 85407 | RNAseq | -0.1666 | 0.8623 | |
| TCGA | NKD1 | 85407 | RNAseq | -0.2627 | 0.1105 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NKD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NKD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NKD1 | 85407 | 3 | 1 | 26 | |
| GSE20123 | NKD1 | 85407 | 3 | 1 | 26 | |
| GSE43470 | NKD1 | 85407 | 2 | 7 | 34 | |
| GSE46452 | NKD1 | 85407 | 38 | 1 | 20 | |
| GSE47630 | NKD1 | 85407 | 11 | 7 | 22 | |
| GSE54993 | NKD1 | 85407 | 2 | 5 | 63 | |
| GSE54994 | NKD1 | 85407 | 6 | 10 | 37 | |
| GSE60625 | NKD1 | 85407 | 4 | 0 | 7 | |
| GSE74703 | NKD1 | 85407 | 2 | 4 | 30 | |
| GSE74704 | NKD1 | 85407 | 3 | 1 | 16 | |
| TCGA | NKD1 | 85407 | 25 | 12 | 59 |
Total number of gains: 99; Total number of losses: 49; Total Number of normals: 340.
Somatic mutations of NKD1:
Generating mutation plots.
Highly correlated genes for NKD1:
Showing top 20/271 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NKD1 | APBB1 | 0.755995 | 3 | 0 | 3 |
| NKD1 | RUSC2 | 0.725996 | 3 | 0 | 3 |
| NKD1 | PAX4 | 0.693578 | 3 | 0 | 3 |
| NKD1 | RS1 | 0.692288 | 3 | 0 | 3 |
| NKD1 | DHRS7C | 0.687009 | 3 | 0 | 3 |
| NKD1 | SNAI1 | 0.685894 | 3 | 0 | 3 |
| NKD1 | CTXN3 | 0.681648 | 3 | 0 | 3 |
| NKD1 | DIP2C | 0.681615 | 3 | 0 | 3 |
| NKD1 | CYS1 | 0.676728 | 3 | 0 | 3 |
| NKD1 | NKX6-1 | 0.675134 | 5 | 0 | 5 |
| NKD1 | CACNA1C | 0.67282 | 4 | 0 | 4 |
| NKD1 | PAM | 0.67279 | 3 | 0 | 3 |
| NKD1 | LINC00205 | 0.66526 | 3 | 0 | 3 |
| NKD1 | MYCN | 0.663879 | 3 | 0 | 3 |
| NKD1 | CCDC116 | 0.663378 | 4 | 0 | 4 |
| NKD1 | ASMTL-AS1 | 0.66083 | 3 | 0 | 3 |
| NKD1 | HS6ST3 | 0.657988 | 4 | 0 | 3 |
| NKD1 | GATA6 | 0.657568 | 3 | 0 | 3 |
| NKD1 | ROS1 | 0.656985 | 4 | 0 | 4 |
| NKD1 | DPEP3 | 0.655665 | 4 | 0 | 4 |
For details and further investigation, click here
