| Full name: fibrillin 1 | Alias Symbol: MASS|OCTD|SGS | ||
| Type: protein-coding gene | Cytoband: 15q21.1 | ||
| Entrez ID: 2200 | HGNC ID: HGNC:3603 | Ensembl Gene: ENSG00000166147 | OMIM ID: 134797 |
| Drug and gene relationship at DGIdb | |||
Expression of FBN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBN1 | 2200 | 202766_s_at | -0.4277 | 0.7852 | |
| GSE20347 | FBN1 | 2200 | 202766_s_at | 1.4609 | 0.0014 | |
| GSE23400 | FBN1 | 2200 | 202766_s_at | 0.4705 | 0.0413 | |
| GSE26886 | FBN1 | 2200 | 202766_s_at | 2.9464 | 0.0000 | |
| GSE29001 | FBN1 | 2200 | 202766_s_at | 1.1247 | 0.0467 | |
| GSE38129 | FBN1 | 2200 | 202766_s_at | 0.8183 | 0.0767 | |
| GSE45670 | FBN1 | 2200 | 202766_s_at | -1.9961 | 0.0044 | |
| GSE63941 | FBN1 | 2200 | 202766_s_at | -8.1446 | 0.0000 | |
| GSE77861 | FBN1 | 2200 | 202766_s_at | 1.4389 | 0.0164 | |
| GSE97050 | FBN1 | 2200 | A_33_P3348239 | -0.5570 | 0.2526 | |
| SRP007169 | FBN1 | 2200 | RNAseq | 4.6936 | 0.0000 | |
| SRP008496 | FBN1 | 2200 | RNAseq | 5.0778 | 0.0000 | |
| SRP064894 | FBN1 | 2200 | RNAseq | 0.6866 | 0.1111 | |
| SRP133303 | FBN1 | 2200 | RNAseq | 0.9872 | 0.0235 | |
| SRP159526 | FBN1 | 2200 | RNAseq | 0.5176 | 0.2313 | |
| SRP193095 | FBN1 | 2200 | RNAseq | 2.4660 | 0.0000 | |
| SRP219564 | FBN1 | 2200 | RNAseq | 0.7750 | 0.3523 | |
| TCGA | FBN1 | 2200 | RNAseq | -0.2095 | 0.1067 |
Upregulated datasets: 7; Downregulated datasets: 2.
Survival by FBN1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FBN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBN1 | 2200 | 5 | 3 | 22 | |
| GSE20123 | FBN1 | 2200 | 5 | 3 | 22 | |
| GSE43470 | FBN1 | 2200 | 5 | 4 | 34 | |
| GSE46452 | FBN1 | 2200 | 3 | 7 | 49 | |
| GSE47630 | FBN1 | 2200 | 8 | 10 | 22 | |
| GSE54993 | FBN1 | 2200 | 4 | 6 | 60 | |
| GSE54994 | FBN1 | 2200 | 5 | 7 | 41 | |
| GSE60625 | FBN1 | 2200 | 4 | 0 | 7 | |
| GSE74703 | FBN1 | 2200 | 5 | 3 | 28 | |
| GSE74704 | FBN1 | 2200 | 2 | 3 | 15 | |
| TCGA | FBN1 | 2200 | 10 | 18 | 68 |
Total number of gains: 56; Total number of losses: 64; Total Number of normals: 368.
Somatic mutations of FBN1:
Generating mutation plots.
Highly correlated genes for FBN1:
Showing top 20/1305 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBN1 | PMP22 | 0.858766 | 10 | 0 | 10 |
| FBN1 | DNM3OS | 0.844818 | 3 | 0 | 3 |
| FBN1 | FSTL1 | 0.844454 | 11 | 0 | 11 |
| FBN1 | LAMA4 | 0.837056 | 10 | 0 | 10 |
| FBN1 | FN1 | 0.835565 | 10 | 0 | 9 |
| FBN1 | PLBD2 | 0.833126 | 3 | 0 | 3 |
| FBN1 | GNG2 | 0.825187 | 4 | 0 | 4 |
| FBN1 | COL6A3 | 0.822284 | 10 | 0 | 10 |
| FBN1 | CTHRC1 | 0.82178 | 4 | 0 | 4 |
| FBN1 | VCAN | 0.811815 | 10 | 0 | 10 |
| FBN1 | CRISPLD2 | 0.805985 | 10 | 0 | 10 |
| FBN1 | GREM1 | 0.805271 | 10 | 0 | 10 |
| FBN1 | RHOBTB1 | 0.804772 | 10 | 0 | 10 |
| FBN1 | COL8A1 | 0.803785 | 8 | 0 | 8 |
| FBN1 | BICC1 | 0.801263 | 8 | 0 | 7 |
| FBN1 | CALD1 | 0.796666 | 11 | 0 | 11 |
| FBN1 | JMY | 0.795549 | 3 | 0 | 3 |
| FBN1 | COL3A1 | 0.789644 | 10 | 0 | 10 |
| FBN1 | LUM | 0.789089 | 10 | 0 | 10 |
| FBN1 | FERMT2 | 0.784632 | 11 | 0 | 11 |
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