| Full name: phospholipase A2 group V | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 5322 | HGNC ID: HGNC:9038 | Ensembl Gene: ENSG00000127472 | OMIM ID: 601192 |
| Drug and gene relationship at DGIdb | |||
PLA2G5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04270 | Vascular smooth muscle contraction |
Expression of PLA2G5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLA2G5 | 5322 | 215870_s_at | -1.4845 | 0.1551 | |
| GSE20347 | PLA2G5 | 5322 | 206178_at | -0.0830 | 0.4770 | |
| GSE23400 | PLA2G5 | 5322 | 206178_at | -0.1942 | 0.0000 | |
| GSE26886 | PLA2G5 | 5322 | 206178_at | -0.0711 | 0.6258 | |
| GSE29001 | PLA2G5 | 5322 | 206178_at | -0.2252 | 0.1443 | |
| GSE38129 | PLA2G5 | 5322 | 206178_at | -0.5769 | 0.0009 | |
| GSE45670 | PLA2G5 | 5322 | 215871_at | 0.0099 | 0.9387 | |
| GSE53622 | PLA2G5 | 5322 | 17322 | -1.1757 | 0.0000 | |
| GSE53624 | PLA2G5 | 5322 | 17322 | -0.9347 | 0.0000 | |
| GSE63941 | PLA2G5 | 5322 | 206178_at | 0.2398 | 0.2097 | |
| GSE77861 | PLA2G5 | 5322 | 206178_at | -0.0191 | 0.8983 | |
| GSE97050 | PLA2G5 | 5322 | A_23_P103465 | -0.7685 | 0.1728 | |
| SRP064894 | PLA2G5 | 5322 | RNAseq | -1.3653 | 0.0008 | |
| SRP133303 | PLA2G5 | 5322 | RNAseq | -0.7735 | 0.2143 | |
| SRP159526 | PLA2G5 | 5322 | RNAseq | -1.7288 | 0.0016 | |
| SRP219564 | PLA2G5 | 5322 | RNAseq | -1.1195 | 0.3536 | |
| TCGA | PLA2G5 | 5322 | RNAseq | -0.8346 | 0.0401 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PLA2G5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLA2G5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLA2G5 | 5322 | 0 | 5 | 25 | |
| GSE20123 | PLA2G5 | 5322 | 0 | 4 | 26 | |
| GSE43470 | PLA2G5 | 5322 | 0 | 8 | 35 | |
| GSE46452 | PLA2G5 | 5322 | 5 | 1 | 53 | |
| GSE47630 | PLA2G5 | 5322 | 8 | 3 | 29 | |
| GSE54993 | PLA2G5 | 5322 | 3 | 1 | 66 | |
| GSE54994 | PLA2G5 | 5322 | 11 | 4 | 38 | |
| GSE60625 | PLA2G5 | 5322 | 0 | 0 | 11 | |
| GSE74703 | PLA2G5 | 5322 | 0 | 5 | 31 | |
| GSE74704 | PLA2G5 | 5322 | 0 | 0 | 20 | |
| TCGA | PLA2G5 | 5322 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of PLA2G5:
Generating mutation plots.
Highly correlated genes for PLA2G5:
Showing top 20/1095 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLA2G5 | NEXN | 0.874254 | 4 | 0 | 4 |
| PLA2G5 | PPP1R14A | 0.869262 | 4 | 0 | 4 |
| PLA2G5 | UBXN10 | 0.816167 | 3 | 0 | 3 |
| PLA2G5 | SORCS1 | 0.804361 | 4 | 0 | 4 |
| PLA2G5 | RAB9B | 0.800603 | 4 | 0 | 4 |
| PLA2G5 | ANO5 | 0.799748 | 4 | 0 | 4 |
| PLA2G5 | ANGPTL1 | 0.797942 | 4 | 0 | 4 |
| PLA2G5 | FILIP1 | 0.794765 | 4 | 0 | 4 |
| PLA2G5 | PLAC9 | 0.794697 | 4 | 0 | 4 |
| PLA2G5 | RYR2 | 0.794177 | 6 | 0 | 6 |
| PLA2G5 | CHRDL1 | 0.783916 | 6 | 0 | 6 |
| PLA2G5 | KANK2 | 0.783344 | 6 | 0 | 6 |
| PLA2G5 | ARHGEF25 | 0.781911 | 4 | 0 | 4 |
| PLA2G5 | PPP1R12B | 0.781067 | 7 | 0 | 7 |
| PLA2G5 | MAMDC2 | 0.780367 | 4 | 0 | 4 |
| PLA2G5 | KATNAL1 | 0.776168 | 3 | 0 | 3 |
| PLA2G5 | SLITRK3 | 0.773431 | 8 | 0 | 8 |
| PLA2G5 | MYOM1 | 0.772286 | 8 | 0 | 7 |
| PLA2G5 | INMT | 0.77203 | 4 | 0 | 4 |
| PLA2G5 | MRVI1 | 0.770044 | 5 | 0 | 5 |
For details and further investigation, click here
