| Full name: dishevelled binding antagonist of beta catenin 3 | Alias Symbol: MGC15476|DAPPER3 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 147906 | HGNC ID: HGNC:30745 | Ensembl Gene: ENSG00000197380 | OMIM ID: 611112 |
| Drug and gene relationship at DGIdb | |||
Expression of DACT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DACT3 | 147906 | 228228_at | -1.0534 | 0.3171 | |
| GSE26886 | DACT3 | 147906 | 228228_at | 0.4470 | 0.0696 | |
| GSE45670 | DACT3 | 147906 | 228228_at | -1.2475 | 0.0000 | |
| GSE53622 | DACT3 | 147906 | 66339 | -0.9103 | 0.0000 | |
| GSE53624 | DACT3 | 147906 | 66339 | -0.7512 | 0.0000 | |
| GSE63941 | DACT3 | 147906 | 228228_at | -2.6975 | 0.0000 | |
| GSE77861 | DACT3 | 147906 | 228228_at | -0.1256 | 0.3741 | |
| GSE97050 | DACT3 | 147906 | A_23_P360964 | -0.9186 | 0.2119 | |
| SRP007169 | DACT3 | 147906 | RNAseq | 1.7954 | 0.0129 | |
| SRP008496 | DACT3 | 147906 | RNAseq | 3.9949 | 0.0000 | |
| SRP064894 | DACT3 | 147906 | RNAseq | 0.4988 | 0.2566 | |
| SRP133303 | DACT3 | 147906 | RNAseq | -0.3119 | 0.5741 | |
| SRP159526 | DACT3 | 147906 | RNAseq | -0.1525 | 0.8139 | |
| SRP219564 | DACT3 | 147906 | RNAseq | -0.5318 | 0.6547 | |
| TCGA | DACT3 | 147906 | RNAseq | -0.6159 | 0.0011 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by DACT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DACT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DACT3 | 147906 | 4 | 4 | 22 | |
| GSE20123 | DACT3 | 147906 | 4 | 3 | 23 | |
| GSE43470 | DACT3 | 147906 | 3 | 11 | 29 | |
| GSE46452 | DACT3 | 147906 | 45 | 1 | 13 | |
| GSE47630 | DACT3 | 147906 | 8 | 7 | 25 | |
| GSE54993 | DACT3 | 147906 | 17 | 4 | 49 | |
| GSE54994 | DACT3 | 147906 | 5 | 13 | 35 | |
| GSE60625 | DACT3 | 147906 | 9 | 0 | 2 | |
| GSE74703 | DACT3 | 147906 | 3 | 7 | 26 | |
| GSE74704 | DACT3 | 147906 | 4 | 1 | 15 | |
| TCGA | DACT3 | 147906 | 14 | 16 | 66 |
Total number of gains: 116; Total number of losses: 67; Total Number of normals: 305.
Somatic mutations of DACT3:
Generating mutation plots.
Highly correlated genes for DACT3:
Showing top 20/945 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DACT3 | DIXDC1 | 0.87472 | 5 | 0 | 5 |
| DACT3 | FAM13C | 0.829446 | 3 | 0 | 3 |
| DACT3 | SLC8A1 | 0.827341 | 5 | 0 | 5 |
| DACT3 | MRVI1 | 0.821854 | 7 | 0 | 7 |
| DACT3 | RASSF3 | 0.820212 | 3 | 0 | 3 |
| DACT3 | NEGR1 | 0.815714 | 6 | 0 | 6 |
| DACT3 | JAM3 | 0.813521 | 7 | 0 | 7 |
| DACT3 | CKMT2 | 0.812671 | 4 | 0 | 4 |
| DACT3 | RAI2 | 0.811199 | 6 | 0 | 6 |
| DACT3 | TBX5 | 0.810993 | 6 | 0 | 6 |
| DACT3 | MAGI2-AS3 | 0.810861 | 6 | 0 | 6 |
| DACT3 | ABCA9 | 0.810067 | 3 | 0 | 3 |
| DACT3 | LRRN4CL | 0.805977 | 6 | 0 | 6 |
| DACT3 | MSRB3 | 0.803621 | 6 | 0 | 6 |
| DACT3 | ASPA | 0.798725 | 5 | 0 | 5 |
| DACT3 | FENDRR | 0.798435 | 6 | 0 | 6 |
| DACT3 | PDE5A | 0.794317 | 7 | 0 | 6 |
| DACT3 | ADCYAP1R1 | 0.79289 | 4 | 0 | 4 |
| DACT3 | MICU3 | 0.787445 | 4 | 0 | 4 |
| DACT3 | ZCCHC24 | 0.786355 | 8 | 0 | 8 |
For details and further investigation, click here
