MAPK12

 

Full name: mitogen-activated protein kinase 12 Alias Symbol: ERK6|PRKM12|p38gamma|SAPK-3
Type: protein-coding gene Cytoband: 22q13.33
Entrez ID: 6300 HGNC ID: HGNC:6874 Ensembl Gene: ENSG00000188130 OMIM ID: 602399
Drug and gene relationship at DGIdb

 

MAPK12 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04015Rap1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04114Oocyte meiosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05133Pertussis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05164Influenza A
hsa05169Epstein-Barr virus infection
hsa05205Proteoglycans in cancer

 

Expression of MAPK12:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAPK12 6300 1556340_at -0.3025 0.2781
GSE20347 MAPK12 6300 206106_at 0.8491 0.0001
GSE23400 MAPK12 6300 206106_at 0.3893 0.0000
GSE26886 MAPK12 6300 1556340_at -0.1048 0.6014
GSE29001 MAPK12 6300 206106_at 0.5849 0.0001
GSE38129 MAPK12 6300 206106_at 0.9534 0.0000
GSE45670 MAPK12 6300 1556340_at 0.0105 0.9381
GSE53622 MAPK12 6300 13069 1.6825 0.0000
GSE53624 MAPK12 6300 13069 1.8195 0.0000
GSE63941 MAPK12 6300 1556340_at 0.4282 0.0239
GSE77861 MAPK12 6300 1556340_at -0.1852 0.2052
GSE97050 MAPK12 6300 A_33_P3250055 -0.2378 0.4012
SRP007169 MAPK12 6300 RNAseq 3.6815 0.0001
SRP008496 MAPK12 6300 RNAseq 3.1971 0.0000
SRP064894 MAPK12 6300 RNAseq 2.6610 0.0000
SRP133303 MAPK12 6300 RNAseq 1.3950 0.0000
SRP159526 MAPK12 6300 RNAseq 2.2764 0.0000
SRP193095 MAPK12 6300 RNAseq 2.9131 0.0000
SRP219564 MAPK12 6300 RNAseq 2.2259 0.0009
TCGA MAPK12 6300 RNAseq 0.7619 0.0000

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by MAPK12 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAPK12:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAPK12 6300 3 8 19
GSE20123 MAPK12 6300 3 8 19
GSE43470 MAPK12 6300 2 8 33
GSE46452 MAPK12 6300 31 2 26
GSE47630 MAPK12 6300 9 4 27
GSE54993 MAPK12 6300 4 6 60
GSE54994 MAPK12 6300 11 8 34
GSE60625 MAPK12 6300 5 0 6
GSE74703 MAPK12 6300 2 6 28
GSE74704 MAPK12 6300 1 4 15
TCGA MAPK12 6300 26 16 54

Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.  

 

Somatic mutations of MAPK12:

 

Generating mutation plots.

 

Highly correlated genes for MAPK12:

 

Showing top 20/364 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAPK12WDR540.762119303
MAPK12RNF2140.744024303
MAPK12CLK30.742801303
MAPK12CCDC1540.736053404
MAPK12PLCD30.729057303
MAPK12MTHFD1L0.722094303
MAPK12KRT710.720262404
MAPK12CACNG60.711738404
MAPK12ZNF7070.70992303
MAPK12RAB340.706143303
MAPK12AVPR1A0.703992303
MAPK12C10orf820.70041303
MAPK12IPO110.699902303
MAPK12DSCR100.698939303
MAPK12MPV17L0.696521504
MAPK12GNG100.694475303
MAPK12PHYHIPL0.693746403
MAPK12C12orf650.691638303
MAPK12POPDC30.687587706
MAPK12B3GNT90.686741303

For details and further investigation, click here