| Full name: hyperpolarization activated cyclic nucleotide gated potassium channel 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 10021 | HGNC ID: HGNC:16882 | Ensembl Gene: ENSG00000138622 | OMIM ID: 605206 |
| Drug and gene relationship at DGIdb | |||
HCN4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04742 | Taste transduction |
Expression of HCN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HCN4 | 10021 | 230208_at | -0.0986 | 0.7546 | |
| GSE20347 | HCN4 | 10021 | 206946_at | -0.0059 | 0.9421 | |
| GSE23400 | HCN4 | 10021 | 206946_at | -0.1197 | 0.0014 | |
| GSE26886 | HCN4 | 10021 | 230208_at | -0.2537 | 0.1214 | |
| GSE29001 | HCN4 | 10021 | 206946_at | -0.1321 | 0.2713 | |
| GSE38129 | HCN4 | 10021 | 206946_at | -0.0757 | 0.2030 | |
| GSE45670 | HCN4 | 10021 | 230208_at | 0.0639 | 0.4774 | |
| GSE53622 | HCN4 | 10021 | 30008 | -0.1145 | 0.0555 | |
| GSE53624 | HCN4 | 10021 | 30008 | 0.1163 | 0.0015 | |
| GSE63941 | HCN4 | 10021 | 230208_at | 0.1729 | 0.3670 | |
| GSE77861 | HCN4 | 10021 | 230208_at | -0.1655 | 0.1731 | |
| TCGA | HCN4 | 10021 | RNAseq | -1.8123 | 0.0670 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HCN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HCN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HCN4 | 10021 | 8 | 0 | 22 | |
| GSE20123 | HCN4 | 10021 | 8 | 0 | 22 | |
| GSE43470 | HCN4 | 10021 | 4 | 6 | 33 | |
| GSE46452 | HCN4 | 10021 | 3 | 7 | 49 | |
| GSE47630 | HCN4 | 10021 | 8 | 10 | 22 | |
| GSE54993 | HCN4 | 10021 | 5 | 6 | 59 | |
| GSE54994 | HCN4 | 10021 | 5 | 9 | 39 | |
| GSE60625 | HCN4 | 10021 | 4 | 4 | 3 | |
| GSE74703 | HCN4 | 10021 | 4 | 3 | 29 | |
| GSE74704 | HCN4 | 10021 | 4 | 0 | 16 | |
| TCGA | HCN4 | 10021 | 12 | 15 | 69 |
Total number of gains: 65; Total number of losses: 60; Total Number of normals: 363.
Somatic mutations of HCN4:
Generating mutation plots.
Highly correlated genes for HCN4:
Showing top 20/650 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HCN4 | APOA5 | 0.727299 | 3 | 0 | 3 |
| HCN4 | MPL | 0.721988 | 3 | 0 | 3 |
| HCN4 | CACNA1H | 0.71704 | 3 | 0 | 3 |
| HCN4 | UBE2D4 | 0.692419 | 3 | 0 | 3 |
| HCN4 | VGF | 0.691993 | 3 | 0 | 3 |
| HCN4 | SLC24A4 | 0.682156 | 3 | 0 | 3 |
| HCN4 | NACAD | 0.679948 | 3 | 0 | 3 |
| HCN4 | PRSS50 | 0.677691 | 3 | 0 | 3 |
| HCN4 | HCG9 | 0.6756 | 3 | 0 | 3 |
| HCN4 | EPO | 0.667827 | 3 | 0 | 3 |
| HCN4 | OPRD1 | 0.667079 | 3 | 0 | 3 |
| HCN4 | FUT7 | 0.666699 | 4 | 0 | 4 |
| HCN4 | LINC01260 | 0.653944 | 6 | 0 | 6 |
| HCN4 | F11 | 0.652942 | 4 | 0 | 4 |
| HCN4 | MC3R | 0.650379 | 3 | 0 | 3 |
| HCN4 | ALX3 | 0.648132 | 4 | 0 | 4 |
| HCN4 | USP29 | 0.646171 | 3 | 0 | 3 |
| HCN4 | GDF10 | 0.643743 | 3 | 0 | 3 |
| HCN4 | SGCA | 0.640392 | 3 | 0 | 3 |
| HCN4 | ALPI | 0.640083 | 3 | 0 | 3 |
For details and further investigation, click here
