| Full name: astacin like metalloendopeptidase | Alias Symbol: ovastacin|SAS1B | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 431705 | HGNC ID: HGNC:31704 | Ensembl Gene: ENSG00000188886 | OMIM ID: 608860 |
| Drug and gene relationship at DGIdb | |||
Expression of ASTL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | ASTL | 431705 | 114705 | 0.1075 | 0.0617 | |
| GSE53624 | ASTL | 431705 | 114705 | 0.2062 | 0.0024 | |
| GSE97050 | ASTL | 431705 | A_33_P3231820 | -0.0103 | 0.9686 | |
| TCGA | ASTL | 431705 | RNAseq | 0.9430 | 0.1445 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ASTL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASTL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASTL | 431705 | 6 | 2 | 22 | |
| GSE20123 | ASTL | 431705 | 6 | 2 | 22 | |
| GSE43470 | ASTL | 431705 | 2 | 3 | 38 | |
| GSE46452 | ASTL | 431705 | 2 | 3 | 54 | |
| GSE47630 | ASTL | 431705 | 7 | 0 | 33 | |
| GSE54993 | ASTL | 431705 | 0 | 6 | 64 | |
| GSE54994 | ASTL | 431705 | 11 | 0 | 42 | |
| GSE60625 | ASTL | 431705 | 0 | 3 | 8 | |
| GSE74703 | ASTL | 431705 | 2 | 2 | 32 | |
| GSE74704 | ASTL | 431705 | 4 | 1 | 15 | |
| TCGA | ASTL | 431705 | 35 | 3 | 58 |
Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.
Somatic mutations of ASTL:
Generating mutation plots.
Highly correlated genes for ASTL:
Showing top 20/82 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASTL | GCM2 | 0.760825 | 3 | 0 | 3 |
| ASTL | CDHR5 | 0.754791 | 3 | 0 | 3 |
| ASTL | ZNF236 | 0.753911 | 3 | 0 | 3 |
| ASTL | PLA2G2C | 0.745811 | 3 | 0 | 3 |
| ASTL | SERPINA10 | 0.739847 | 3 | 0 | 3 |
| ASTL | SLC26A1 | 0.738216 | 3 | 0 | 3 |
| ASTL | TMEM235 | 0.73713 | 3 | 0 | 3 |
| ASTL | LACRT | 0.73353 | 3 | 0 | 3 |
| ASTL | CIB3 | 0.733284 | 3 | 0 | 3 |
| ASTL | ALPP | 0.733185 | 3 | 0 | 3 |
| ASTL | C2orf72 | 0.732849 | 3 | 0 | 3 |
| ASTL | ST8SIA3 | 0.732395 | 3 | 0 | 3 |
| ASTL | TMEM105 | 0.728427 | 3 | 0 | 3 |
| ASTL | PDZD7 | 0.726566 | 3 | 0 | 3 |
| ASTL | OR2T27 | 0.725458 | 3 | 0 | 3 |
| ASTL | FOXE3 | 0.724247 | 3 | 0 | 3 |
| ASTL | WDR87 | 0.722807 | 3 | 0 | 3 |
| ASTL | SLC39A5 | 0.720764 | 3 | 0 | 3 |
| ASTL | KRT74 | 0.718211 | 3 | 0 | 3 |
| ASTL | SPACA3 | 0.716211 | 3 | 0 | 3 |
For details and further investigation, click here
